[HTML][HTML] Pathophysiology of the antiphospholipid syndrome
PG De Groot, R Derksen - Journal of Thrombosis and Haemostasis, 2005 - Elsevier
… We have solid evidence that plasma and recombinant β2GPI exist in different conformations
(de Laat B, Derksen RHWM, de Groot PG, unpubl. data). We suggest that binding of plasma …
(de Laat B, Derksen RHWM, de Groot PG, unpubl. data). We suggest that binding of plasma …
The use of glucocorticoids in systemic lupus erythematosus. After 60 years still more an art than science
RK Luijten, RD Fritsch-Stork, JWJ Bijlsma… - Autoimmunity …, 2013 - Elsevier
Systemic Lupus Erythematosus (SLE) is a clinically diverse, chronic autoimmune disease
with inflammation in several organ systems. Its pathogenesis is complex, but includes many …
with inflammation in several organ systems. Its pathogenesis is complex, but includes many …
Delineating the deranged immune system in the antiphospholipid syndrome
LL van den Hoogen, JAG van Roon… - Autoimmunity …, 2016 - Elsevier
The antiphospholipid syndrome (APS) is a systemic autoimmune disease that is characterized
serologically by the presence of antiphospholipid antibodies (aPL) and clinically by …
serologically by the presence of antiphospholipid antibodies (aPL) and clinically by …
[HTML][HTML] International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
New clinical, laboratory and experimental insights, since the 1999 publication of the
Sapporo preliminary classification criteria for antiphospholipid syndrome (APS), had been …
Sapporo preliminary classification criteria for antiphospholipid syndrome (APS), had been …
The “primary” antiphospholipid syndrome: major clinical and serological features
RA ASHERSON, MA KHAMASHTA, J Ordi-Ros… - Medicine, 1989 - journals.lww.com
ASHERSON, RONALD AMD, FACP, FCP,(SA) 1; KHAMASHTA, MUNTHER AMD 1; ORDI-ROS,
JOSE MD 3; DERKSEN, RONALD HWMMD 2; MACHIN, SAMUEL JMD, FRC PATH. 4; …
JOSE MD 3; DERKSEN, RONALD HWMMD 2; MACHIN, SAMUEL JMD, FRC PATH. 4; …
Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients
R Cervera, R Serrano, GJ Pons-Estel… - Annals of the …, 2015 - ard.bmj.com
Objectives To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid
syndrome (APS) during a 10-year-follow-up period and to compare the frequency of …
syndrome (APS) during a 10-year-follow-up period and to compare the frequency of …
Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients
R Cervera, JC Piette, J Font… - … : Official Journal of …, 2002 - Wiley Online Library
Objective To analyze the clinical and immunologic manifestations of antiphospholipid
syndrome (APS) in a large cohort of patients and to define patterns of disease expression. …
syndrome (APS) in a large cohort of patients and to define patterns of disease expression. …
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at …
G Ruiz-Irastorza, MJ Cuadrado, I Ruiz-Arruza… - Lupus, 2011 - journals.sagepub.com
The antiphospholipid syndrome (APS) is defined by the presence of thrombosis and/or
pregnancy morbidity in combination with the persistent presence of circulating antiphospholipid …
pregnancy morbidity in combination with the persistent presence of circulating antiphospholipid …
IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2–glycoprotein I cause LAC, and their presence correlates strongly with thrombosis
B De Laat, RHWM Derksen, RT Urbanus, PG De Groot - Blood, 2005 - ashpublications.org
Anti–β 2 –glycoprotein I antibodies are known to have a heterogeneous reactivity against β
2 –glycoprotein I. We performed this study to characterize the epitope on β 2 –glycoprotein I …
2 –glycoprotein I. We performed this study to characterize the epitope on β 2 –glycoprotein I …
[HTML][HTML] Adhesion mechanism of human β2-glycoprotein I to phospholipids based on its crystal structure
B Bouma, PG de Groot, JMH van den Elsen… - The EMBO …, 1999 - embopress.org
Human β 2-glycoprotein I is a heavily glycosylated five-domain plasma membrane-adhesion
protein, which has been implicated in blood coagulation and clearance of apoptotic bodies …
protein, which has been implicated in blood coagulation and clearance of apoptotic bodies …