[HTML][HTML] Pathophysiology of the antiphospholipid syndrome

PG De Groot, R Derksen - Journal of Thrombosis and Haemostasis, 2005 - Elsevier
… We have solid evidence that plasma and recombinant β2GPI exist in different conformations
(de Laat B, Derksen RHWM, de Groot PG, unpubl. data). We suggest that binding of plasma …

The use of glucocorticoids in systemic lupus erythematosus. After 60 years still more an art than science

RK Luijten, RD Fritsch-Stork, JWJ Bijlsma… - Autoimmunity …, 2013 - Elsevier
Systemic Lupus Erythematosus (SLE) is a clinically diverse, chronic autoimmune disease
with inflammation in several organ systems. Its pathogenesis is complex, but includes many …

Delineating the deranged immune system in the antiphospholipid syndrome

LL van den Hoogen, JAG van Roon… - Autoimmunity …, 2016 - Elsevier
The antiphospholipid syndrome (APS) is a systemic autoimmune disease that is characterized
serologically by the presence of antiphospholipid antibodies (aPL) and clinically by …

[HTML][HTML] International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

S Miyakis, MD Lockshin, T Atsumi, DW Branch… - Journal of thrombosis …, 2006 - Elsevier
New clinical, laboratory and experimental insights, since the 1999 publication of the
Sapporo preliminary classification criteria for antiphospholipid syndrome (APS), had been …

The “primary” antiphospholipid syndrome: major clinical and serological features

RA ASHERSON, MA KHAMASHTA, J Ordi-Ros… - Medicine, 1989 - journals.lww.com
ASHERSON, RONALD AMD, FACP, FCP,(SA) 1; KHAMASHTA, MUNTHER AMD 1; ORDI-ROS,
JOSE MD 3; DERKSEN, RONALD HWMMD 2; MACHIN, SAMUEL JMD, FRC PATH. 4; …

Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients

R Cervera, R Serrano, GJ Pons-Estel… - Annals of the …, 2015 - ard.bmj.com
Objectives To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid
syndrome (APS) during a 10-year-follow-up period and to compare the frequency of …

Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients

R Cervera, JC Piette, J Font… - … : Official Journal of …, 2002 - Wiley Online Library
Objective To analyze the clinical and immunologic manifestations of antiphospholipid
syndrome (APS) in a large cohort of patients and to define patterns of disease expression. …

Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at …

G Ruiz-Irastorza, MJ Cuadrado, I Ruiz-Arruza… - Lupus, 2011 - journals.sagepub.com
The antiphospholipid syndrome (APS) is defined by the presence of thrombosis and/or
pregnancy morbidity in combination with the persistent presence of circulating antiphospholipid …

IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2–glycoprotein I cause LAC, and their presence correlates strongly with thrombosis

B De Laat, RHWM Derksen, RT Urbanus, PG De Groot - Blood, 2005 - ashpublications.org
Anti–β 2 –glycoprotein I antibodies are known to have a heterogeneous reactivity against β
2 –glycoprotein I. We performed this study to characterize the epitope on β 2 –glycoprotein I …

[HTML][HTML] Adhesion mechanism of human β2-glycoprotein I to phospholipids based on its crystal structure

B Bouma, PG de Groot, JMH van den Elsen… - The EMBO …, 1999 - embopress.org
Human β 2-glycoprotein I is a heavily glycosylated five-domain plasma membrane-adhesion
protein, which has been implicated in blood coagulation and clearance of apoptotic bodies …