Retinoblastoma and neuroblastoma predisposition and surveillance
J Kamihara, F Bourdeaut, WD Foulkes… - Clinical Cancer …, 2017 - AACR
Retinoblastoma (RB) is the most common intraocular malignancy in childhood. Approximately
40% of retinoblastomas are hereditary and due to germline mutations in the RB1 gene. …
40% of retinoblastomas are hereditary and due to germline mutations in the RB1 gene. …
[HTML][HTML] The immune landscape of neuroblastoma: challenges and opportunities for novel therapeutic strategies in pediatric oncology
J Wienke, MP Dierselhuis, GAM Tytgat… - European journal of …, 2021 - Elsevier
Immunotherapy holds great promise for the treatment of pediatric cancers. In neuroblastoma,
the recent implementation of anti-GD2 antibody Dinutuximab into the standard of care has …
the recent implementation of anti-GD2 antibody Dinutuximab into the standard of care has …
Cancer surveillance in Gorlin syndrome and rhabdoid tumor predisposition syndrome
Gorlin syndrome and rhabdoid tumor predisposition syndrome (RTPS) are autosomal
dominant syndromes associated with an increased risk of childhood-onset brain tumors. …
dominant syndromes associated with an increased risk of childhood-onset brain tumors. …
[HTML][HTML] Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The
pathogenesis has for a long time been quite enigmatic, as only very few gene defects were …
pathogenesis has for a long time been quite enigmatic, as only very few gene defects were …
[HTML][HTML] The landscape of genomic alterations across childhood cancers
SN Gröbner, BC Worst, J Weischenfeldt, I Buchhalter… - Nature, 2018 - nature.com
Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
[HTML][HTML] Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …
Neuroblastoma is composed of two super-enhancer-associated differentiation states
T Van Groningen, J Koster, LJ Valentijn… - Nature …, 2017 - nature.com
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has
sparked an interest in their epigenetic regulation. Several tumor types include phenotypically …
sparked an interest in their epigenetic regulation. Several tumor types include phenotypically …
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy,
but a large proportion will experience therapy-resistant relapses. The molecular basis of …
but a large proportion will experience therapy-resistant relapses. The molecular basis of …
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
JJ Molenaar, R Domingo-Fernández, ME Ebus… - Nature …, 2012 - nature.com
LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo. …
family. A role for LIN28B in cancer has been proposed but has not been established in vivo. …
TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors
LJ Valentijn, J Koster, DA Zwijnenburg, NE Hasselt… - Nature …, 2015 - nature.com
Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage
neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were …
neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were …