Performance of controllers applied in biotechnological production is often below expectation.
Online automatic tuning has the capability to improve control performance by adjusting …

This study considers two aspects of the implementation of a biomass growth observer and
specific growth rate controller in scale-up from small- to pilot-scale bioreactors towards a …

Understanding the growth characteristics of microorganisms is an essential step in bioprocessing,
not only because product formation may be growth-associated but also because they …

At specific growth rates above a particular critical value, Crabtree-positive microorganisms
exceed their respiratory capacity and enter diauxic growth metabolism. Excess substrate is …

Reliable control of the specific growth rate (μ) in fed-batch fermentations depends on the
availability of accurate online estimations of the controlled variable. Due to difficulties in …

This paper deals with the regulation of the biomass specific growth rate, which is an important
goal in many fed-batch fermentation processes. The proposed control system is based on …

For biological fermentation processes in vaccine manufacturing, the development of a
robust controller is essential to manage uncertainty in the process model and external …

Model Predictive Control (MPC) is a control strategy which utilizes a process model to compute
a sequence of control moves with a desired control objective of tracking the desired level …

This paper deals with the estimation of unknown signals in bioreactors using sliding observers.
Particular attention is drawn to estimate the specific growth rate of microorganisms from …

The fed-batch cultivation is in many ways a benchmark for fermentation processes, and it has
been an attractive choice for the biotechnological production of various products in the past …