Protein biochips are at the heart of many medical and bioanalytical applications. Increasing
interest has been focused on surface activation and subsequent functionalization strategies …

In the continuing effort to find small molecules that alter protein function and ultimately might
lead to new drugs, combinatorial chemistry has emerged as a very powerful tool. Contrary to …

Alkaloids are an important class of natural products that are widely distributed in nature and
produced by a large variety of organisms. They have a wide spectrum of biological activity …

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six
hypervariable regions from the heavy- and light-chain variable domains of a rat antibody …

Cell lines have been established that secrete a matched set of human chimeric IgM, IgG1,
IgG2, IgG3, IgG4, IgE, and IgA2 antibodies that are directed against the hapten 4-hydroxy-3-…

A major aim in immunology has been to understand how the immune system evokes
characteristic responses to infection, foreign tissue grafts and tumours. The current view of …

The maintenance of transplantation tolerance induced in adult mice after short-term treatment
with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4 + T cells from …

Background Type 1 diabetes mellitus is a T-cell–mediated autoimmune disease that leads
to a major loss of insulin-secreting beta cells. The further decline of beta-cell function after …

A novel cell surface antigen has been identified on a wide range of lymphoid cells and
erythrocytes. A mAb YTH 53.1 (CD59) against this antigen enhanced the lysis of human red cells …

We show that the specific subcellular distribution of H- and Nras guanosine triphosphate–binding
proteins is generated by a constitutive de/reacylation cycle that operates on …