Immune evasion by Epstein-Barr virus

ME Ressing, M van Gent, AM Gram… - Epstein Barr Virus …, 2015 - Springer
Epstein-Bar virus (EBV) is widespread within the human population with over 90 % of adults
being infected. In response to primary EBV infection, the host mounts an antiviral immune …

Epstein-Barr virus evasion of CD8+ and CD4+ T cell immunity via concerted actions of multiple gene products

ME Ressing, D Horst, BD Griffin, J Tellam, J Zuo… - Seminars in cancer …, 2008 - Elsevier
Upon primary infection, EBV establishes a latent infection in B cells, characterized by
maintenance of the viral genome in the absence of viral replication. The Epstein-Barr Nuclear …

Herpesviruses and immunity: the art of evasion

BD Griffin, MC Verweij, EJHJ Wiertz - Veterinary microbiology, 2010 - Elsevier
Herpesviruses have evolved several effective strategies to counter the host immune
response. Chief among these is inhibition of the host MHC class I antigen processing and …

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

EJHJ Wiertz, D Tortorella, M Bogyo, J Yu, W Mothes… - Nature, 1996 - nature.com
The human cytomegalovirus genome encodes proteins that trigger destruction of newly
synthesized major histocompatibility complex (MHC) class I molecules. The human …

[HTML][HTML] The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

EJHJ Wiertz, TR Jones, L Sun, M Bogyo, HJ Geuze… - Cell, 1996 - cell.com
Human cytomegalovirus (HCMV) down-regulates expression of MHC class I products by
selective proteolysis. A single HCMV gene, US11, which encodes an endoplasmic reticulum (…

[PDF][PDF] The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

K Ahn, A Gruhler, B Galocha, TR Jones, EJHJ Wiertz… - Immunity, 1997 - cell.com
Human cytomegalovirus (HCMV) inhibits MHC class I antigen presentation by a sequential
multistep process involving a family of unique short (US) region–encoded glycoproteins. US3 …

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3

X Wang, RA Herr, WJ Chua, L Lybarger… - The Journal of cell …, 2007 - rupress.org
The mechanism by which substrates for endoplasmic reticulum–associated degradation are
retrotranslocated to the cytosol remains largely unknown, although ubiquitination is known …

[HTML][HTML] CRISPR/Cas9-mediated genome editing of herpesviruses limits productive and latent infections

FR van Diemen, EM Kruse, MJG Hooykaas… - PLoS …, 2016 - journals.plos.org
Herpesviruses infect the majority of the human population and can cause significant morbidity
and mortality. Herpes simplex virus (HSV) type 1 causes cold sores and herpes simplex …

Host shutoff during productive Epstein–Barr virus infection is mediated by BGLF5 and may contribute to immune evasion

M Rowe, B Glaunsinger… - Proceedings of the …, 2007 - National Acad Sciences
Relatively little is known about immune evasion during the productive phase of infection by
the γ 1 -herpesvirus Epstein–Barr virus (EBV). The use of a unique system to isolate cells in …

Varicelloviruses avoid T cell recognition by UL49. 5-mediated inactivation of the transporter associated with antigen processing

D Koppers-Lalic, EAJ Reits… - Proceedings of the …, 2005 - National Acad Sciences
Detection and elimination of virus-infected cells by cytotoxic T lymphocytes depends on
recognition of virus-derived peptides presented by MHC class I molecules. A critical step in this …