Experimental study of the detrimental effect of dopamine/glucagon combination in d, l-propranolol intoxication

AE Toet, J Wemer, W Vleeming… - Human & …, 1996 - journals.sagepub.com
1 Respiratory and cardiovascular failure are the princi ple toxic effects of β-blocker overdose.
Respiratory arrest is the primary cause of death in β-blocker intoxicated rats. 2 The effect of …

Reduced survival after isoprenaline/dopamine in d, l-propranolol intoxicated rats

AE Toet, JD Te Biesebeek… - Human & …, 1996 - journals.sagepub.com
1 Respiratory and cardiovascular failure are principle toxic effects of β-blocker overdose.
Respiratory arrest is the primary cause of death in β-blocker intoxicated rats. 2 The effect of β-…

Toxicokinetics of a single intravenous dose of rac‐propranolol versus optically pure propranolol in the rat

W Bode, AE Toet, AAM Stolker, LA Van Ginkel… - Chirality, 1995 - Wiley Online Library
Conscious male Wistar SPF Riv:TOX rats were dosed intravenously with 2.5, 5, or 10 mg/kg
rac‐propranolol·HCl, or with 5 mg/kg of either (‐)‐(S)‐ or (+)‐(R)‐propranolol·HCl. …

Central origin of respiratory arrest in beta-blocker intoxication in rats

JJM Langemeijer, DJ De Wildt, G De Groot… - Toxicology and applied …, 1987 - Elsevier
Propranolol HCl (7.5 mg·kg −1 ), timolol maleate (7.0 mg·kg −1 ), and sotalol HCl (10 mg·kg
−1 ) were administered intracerebroventricularly (icv) to spontaneously breathing (SB) rats. …

Toxic doses of rac‐, (−)‐(S)‐ and (+)‐(R)‐propranolol in rats and rabbits

AE Toet, AV De Kuil, W Vleeming, J Wemer, W Bode… - Chirality, 1996 - Wiley Online Library
The contribution of the individual enantiomers ([+]‐[R]‐ and [−]‐[S]‐propranolol) to rac‐propranolol
intoxication was studied in anaesthetized, spontaneously breathing (SB) rats and …

Repeated administration of whole-cell and acellular pertussis vaccines affects haemodynamics and autonomic responsiveness

JGC van Amsterdam, JD te Biesebeek, T van de Kuil… - Vaccine, 1998 - Elsevier
Rats were treated in a repetitive way one to four times with either pertussis toxin, combined
Diphtheria-Tetanus-Poliomyelitis-Pertussis vaccine (DTP-IPV vaccine, which includes …

Disturbance of cardiovascular circadian rhythms by pertussis vaccine in freely-moving rats

W Vleeming, A Van de Kuil… - Laboratory …, 2000 - journals.sagepub.com
Vaccination of young children with diphtheria, tetanus, poliomyelitis and pertussis (DTPoP)
vaccine is effective in preventing outbreaks of whooping cough but adverse events …

The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age

JGC van Amsterdam, JD te Biesebeek, T van de Kuil… - Vaccine, 1998 - Elsevier
Vaccination of children with Diphtheria, Tetanus, Poliomyelitis and Pertussis vaccine (DTPoP-vaccine)
containing the whole-cell pertussis component is known to be associated with …

Tijd-effect relaties voor pertussis toxine geinduceerde effecten

DJ de Wildt, NPJ Blokhuijzen… - RIVM Rapport …, 1987 - rivm.openrepository.com
In 2 separate onderzoeken bij de rat zijn tijd-effect relaties opgesteld met betrekking tot de
effecten van pertussis toxine (PT) op de hemodynamiek en autonome receptorgevoeligheid …

Bepaling van isosorbide-dinitraat en zijn metabolieten isosorbide-2-mononitraat en isosorbide-5-mononitraat in ratteserum met behulp van capillaire …

BCA Tepas, G de Groot… - RIVM Rapport …, 1989 - rivm.openrepository.com
In dit rapport wordt een gevoelige methode beschreven voor de kwantitatieve bepaling in
ratteserum van het vaatverwijdende middel isosorbide-dinitraat (ISDN) en zijn metabolieten …