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Matt Hepworth
Matt Hepworth
Verified email at manchester.ac.uk - Homepage
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Year
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
MR Hepworth, LA Monticelli, TC Fung, CGK Ziegler, S Grunberg, R Sinha, ...
Nature 498 (7452), 113-117, 2013
8442013
TSLP elicits IL-33–independent innate lymphoid cell responses to promote skin inflammation
BS Kim, MC Siracusa, SA Saenz, M Noti, LA Monticelli, GF Sonnenberg, ...
Science translational medicine 5 (170), 170ra16-170ra16, 2013
7782013
Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4+ T cells
MR Hepworth, TC Fung, SH Masur, JR Kelsen, FM McConnell, J Dubrot, ...
Science 348 (6238), 1031-1035, 2015
5232015
IL-33, a potent inducer of adaptive immunity to intestinal nematodes
NE Humphreys, D Xu, MR Hepworth, FY Liew, RK Grencis
The Journal of Immunology 180 (4), 2443-2449, 2008
5042008
Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
LC Osborne, LA Monticelli, TJ Nice, TE Sutherland, MC Siracusa, ...
Science 345 (6196), 578-582, 2014
2742014
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation
LA Monticelli, MD Buck, AL Flamar, SA Saenz, ED Tait Wojno, ...
Nature immunology 17 (6), 656-665, 2016
2532016
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells
DR Withers, MR Hepworth, X Wang, EC Mackley, EE Halford, EE Dutton, ...
Nature medicine 22 (3), 319-323, 2016
2362016
Functional interactions between innate lymphoid cells and adaptive immunity
GF Sonnenberg, MR Hepworth
Nature Reviews Immunology 19 (10), 599-613, 2019
2192019
CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes
EC Mackley, S Houston, CL Marriott, EE Halford, B Lucas, V Cerovic, ...
Nature communications 6 (1), 5862, 2015
2092015
Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines
MR Hepworth, E Daniłowicz-Luebert, S Rausch, M Metz, C Klotz, ...
Proceedings of the National Academy of Sciences 109 (17), 6644-6649, 2012
2002012
Functional and phenotypic heterogeneity of group 3 innate lymphoid cells
F Melo‐Gonzalez, MR Hepworth
Immunology 150 (3), 265-275, 2017
1922017
Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation
J Emgård, H Kammoun, B García-Cassani, J Chesné, SM Parigi, ...
Immunity 48 (1), 120-132. e8, 2018
1702018
A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages
C Klotz, T Ziegler, AS Figueiredo, S Rausch, MR Hepworth, N Obsivac, ...
PLoS pathogens 7 (1), e1001248, 2011
1632011
Lymphoid-tissue-resident commensal bacteria promote members of the IL-10 cytokine family to establish mutualism
TC Fung, NJ Bessman, MR Hepworth, N Kumar, N Shibata, D Kobuley, ...
Immunity 44 (3), 634-646, 2016
1542016
Antigen-presenting ILC3 regulate T cell–dependent IgA responses to colonic mucosal bacteria
F Melo-Gonzalez, H Kammoun, E Evren, EE Dutton, M Papadopoulou, ...
Journal of Experimental Medicine 216 (4), 728-742, 2019
1312019
A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation
T Ziegler, S Rausch, S Steinfelder, C Klotz, MR Hepworth, AA Kühl, ...
The Journal of Immunology 194 (4), 1555-1564, 2015
1052015
The role of sex hormones in the development of Th2 immunity in a gender‐biased model of Trichuris muris infection
MR Hepworth, MJ Hardman, RK Grencis
European journal of immunology 40 (2), 406-416, 2010
1032010
Group 3 innate lymphoid cells: communications hubs of the intestinal immune system
DR Withers, MR Hepworth
Frontiers in immunology 8, 300799, 2017
922017
Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells
S Rausch, J Huehn, C Loddenkemper, MR Hepworth, C Klotz, ...
European journal of immunology 39 (11), 3066-3077, 2009
922009
IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology
J Stange, MR Hepworth, S Rausch, L Zajic, AA Kühl, C Uyttenhove, ...
The Journal of Immunology 188 (5), 2410-2418, 2012
772012
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