| Mildronate: cardioprotective action through carnitine-lowering effect M Dambrova, E Liepinsh, I Kalvinsh Trends in cardiovascular medicine 12 (6), 275-279, 2002 | 257 | 2002 |
| Diabetes is associated with higher trimethylamine N-oxide plasma levels M Dambrova, G Latkovskis, J Kuka, I Strele, I Konrade, S Grinberga, ... Experimental and clinical endocrinology & diabetes 124 (04), 251-256, 2016 | 224 | 2016 |
| Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity M Dambrova, M Makrecka-Kuka, R Vilskersts, E Makarova, J Kuka, ... Pharmacological research 113, 771-780, 2016 | 151 | 2016 |
| Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials M Dambrova, M Makrecka-Kuka, J Kuka, R Vilskersts, D Nordberg, ... Pharmacological Reviews 74 (3), 506-551, 2022 | 144 | 2022 |
| Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction E Liepinsh, R Vilskersts, D Loca, O Kirjanova, O Pugovichs, I Kalvinsh, ... Journal of cardiovascular pharmacology 48 (6), 314-319, 2006 | 131 | 2006 |
| Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues M Makrecka-Kuka, E Sevostjanovs, K Vilks, K Volska, U Antone, J Kuka, ... Scientific reports 7 (1), 17528, 2017 | 121 | 2017 |
| Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation J Kuka, E Liepinsh, M Makrecka-Kuka, J Liepins, H Cirule, D Gustina, ... Life sciences 117 (2), 84-92, 2014 | 117 | 2014 |
| Cardiac metabolism as a driver and therapeutic target of myocardial infarction CJ Zuurbier, L Bertrand, CR Beauloye, I Andreadou, M Ruiz‐Meana, ... Journal of cellular and molecular medicine 24 (11), 5937-5954, 2020 | 113 | 2020 |
| Protective effects of mildronate in an experimental model of type 2 diabetes in Goto‐Kakizaki rats E Liepinsh, R Vilskersts, L Zvejniece, B Svalbe, E Skapare, J Kuka, ... British journal of pharmacology 157 (8), 1549-1556, 2009 | 108 | 2009 |
| Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria M Makrecka-Kuka, K Volska, U Antone, R Vilskersts, S Grinberga, ... Toxicology letters 267, 32-38, 2017 | 100 | 2017 |
| Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury M Dambrova, CJ Zuurbier, V Borutaite, E Liepinsh, M Makrecka-Kuka Free Radical Biology and Medicine 165, 24-37, 2021 | 97 | 2021 |
| Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart E Liepinsh, R Vilskersts, E Skapare, B Svalbe, J Kuka, H Cirule, ... Life sciences 83 (17-18), 613-619, 2008 | 96 | 2008 |
| Comparative pharmacological activity of optical isomers of phenibut M Dambrova, L Zvejniece, E Liepinsh, H Cirule, O Zharkova, G Veinberg, ... European journal of pharmacology 583 (1), 128-134, 2008 | 96 | 2008 |
| Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria E Liepinsh, M Makrecka-Kuka, K Volska, J Kuka, E Makarova, U Antone, ... Biochemical Journal 473 (9), 1191-1202, 2016 | 86 | 2016 |
| Structure and function of CutC choline lyase from human microbiota bacterium Klebsiella pneumoniae G Kalnins, J Kuka, S Grinberga, M Makrecka-Kuka, E Liepinsh, ... Journal of Biological Chemistry 290 (35), 21732-21740, 2015 | 83 | 2015 |
| Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism K Jaudzems, J Kuka, A Gutsaits, K Zinovjevs, I Kalvinsh, E Liepinsh, ... Journal of enzyme inhibition and medicinal chemistry 24 (6), 1269-1275, 2009 | 82 | 2009 |
| Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients E Skapare, I Konrade, E Liepinsh, I Strele, M Makrecka, A Bierhaus, ... Journal of Diabetes and its Complications 27 (3), 262-267, 2013 | 78 | 2013 |
| The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine J Kuka, R Vilskersts, H Cirule, M Makrecka, O Pugovics, I Kalvinsh, ... Journal of Cardiovascular Pharmacology and Therapeutics 17 (2), 215-222, 2012 | 77 | 2012 |
| Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers E Liepinsh, I Konrade, E Skapare, O Pugovics, S Grinberga, J Kuka, ... Journal of Pharmacy and Pharmacology 63 (9), 1195-1201, 2011 | 76 | 2011 |
| Altered mitochondrial metabolism in the insulin‐resistant heart M Makrecka‐Kuka, E Liepinsh, AJ Murray, H Lemieux, M Dambrova, ... Acta Physiologica 228 (3), e13430, 2020 | 71 | 2020 |
