Leon Schurgers
Leon Schurgers
Professor of biochemistry of vascular calcification, CARIM, Maastricht University
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Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism …
JL Reynolds, AJ Joannides, JN Skepper, R McNair, LJ Schurgers, ...
Journal of the American Society of Nephrology 15 (11), 2857-2867, 2004
Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
JM Geleijnse, C Vermeer, DE Grobbee, LJ Schurgers, MHJ Knapen, ...
The Journal of nutrition 134 (11), 3100-3105, 2004
Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis
RC Shroff, R McNair, N Figg, JN Skepper, L Schurgers, A Gupta, M Hiorns, ...
Circulation 118 (17), 1748-1757, 2008
The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study
BD Parker, LJ Schurgers, VM Brandenburg, RH Christenson, C Vermeer, ...
Annals of internal medicine 152 (10), 640-648, 2010
Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis
R Rennenberg, AGH Kessels, LJ Schurgers, JMA Van Engelshoven, ...
Vascular health and risk management 5, 185, 2009
Determination of phylloquinone and menaquinones in food
LJ Schurgers, C Vermeer
Pathophysiology of Haemostasis and Thrombosis 30 (6), 298-307, 2000
Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
LJ Schurgers, KJF Teunissen, K Hamulyák, MHJ Knapen, H Vik, ...
Blood 109 (8), 3279-3283, 2007
Vascular smooth muscle cell calcification is mediated by regulated exosome secretion
AN Kapustin, MLL Chatrou, I Drozdov, Y Zheng, SM Davidson, D Soong, ...
Circulation research 116 (8), 1312-1323, 2015
Calcium regulates key components of vascular smooth muscle cell–derived matrix vesicles to enhance mineralization
AN Kapustin, JD Davies, JL Reynolds, R McNair, GT Jones, A Sidibe, ...
Circulation research 109 (1), e1-e12, 2011
Novel conformation-specific antibodies against matrix γ-carboxyglutamic acid (Gla) protein: Undercarboxylated matrix Gla protein as marker for vascular calcification
LJ Schurgers, KJF Teunissen, MHJ Knapen, M Kwaijtaal, R van Diest, ...
Arteriosclerosis, thrombosis, and vascular biology 25 (8), 1629-1633, 2005
Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
LJ Schurgers, HMH Spronk, BAM Soute, PM Schiffers, JGR DeMey, ...
Blood 109 (7), 2823-2831, 2007
Matrix Gla-protein: the calcification inhibitor in need of vitamin K
LJ Schurgers, ECM Cranenburg, C Vermeer
Thrombosis and haemostasis 100 (10), 593-603, 2008
Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial
R Westenfeld, T Krueger, G Schlieper, ECM Cranenburg, EJ Magdeleyns, ...
American journal of kidney diseases 59 (2), 186-195, 2012
Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification
RC Shroff, R McNair, JN Skepper, N Figg, LJ Schurgers, J Deanfield, ...
Journal of the American Society of Nephrology 21 (1), 103-112, 2010
The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report
LJ Schurgers, DV Barreto, FC Barreto, S Liabeuf, C Renard, ...
Clinical journal of the American society of nephrology 5 (4), 568-575, 2010
Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
MHJ Knapen, LJ Schurgers, C Vermeer
Osteoporosis international 18 (7), 963-972, 2007
Vitamin K: the coagulation vitamin that became omnipotent
ECM Cranenburg, LJ Schurgers, C Vermeer
Thrombosis and haemostasis 98 (07), 120-125, 2007
Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization
LJ Schurgers, J Uitto, CP Reutelingsperger
Trends in molecular medicine 19 (4), 217-226, 2013
Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD
G Schlieper, R Westenfeld, T Krüger, EC Cranenburg, EJ Magdeleyns, ...
Journal of the American Society of Nephrology 22 (2), 387-395, 2011
Post‐translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
LJ Schurgers, HMH Spronk, JN Skepper, TM Hackeng, CM Shanahan, ...
Journal of Thrombosis and Haemostasis 5 (12), 2503-2511, 2007
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