|Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics|
IA Kaltashov, CE Bobst, RR Abzalimov, G Wang, B Baykal, S Wang
Biotechnology advances 30 (1), 210-222, 2012
|A novel platform for the potentiation of therapeutic antibodies based on antigen-dependent formation of IgG hexamers at the cell surface|
RN de Jong, FJ Beurskens, S Verploegen, K Strumane, MD van Kampen, ...
PLoS biology 14 (1), e1002344, 2016
|Tandem native mass-spectrometry on antibody–drug conjugates and submillion Da antibody–antigen protein assemblies on an Orbitrap EMR equipped with a high-mass quadrupole mass …|
A Dyachenko, G Wang, M Belov, A Makarov, RN De Jong, ...
Analytical chemistry 87 (12), 6095-6102, 2015
|Molecular basis of assembly and activation of complement component C1 in complex with immunoglobulin G1 and antigen|
G Wang, RN de Jong, ETJ van den Bremer, FJ Beurskens, AF Labrijn, ...
Molecular cell 63 (1), 135-145, 2016
|Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches|
Y Yang, G Wang, T Song, CB Lebrilla, AJR Heck
MAbs 9 (4), 638-645, 2017
|Direct monitoring of heat-stressed biopolymers with temperature-controlled electrospray ionization mass spectrometry|
G Wang, RR Abzalimov, IA Kaltashov
Analytical chemistry 83 (8), 2870-2876, 2011
|Evaluation of electrospray ionization mass spectrometry as a tool for characterization of small soluble protein aggregates|
G Wang, AJ Johnson, IA Kaltashov
Analytical chemistry 84 (3), 1718-1724, 2012
|RNA sequencing by direct tagmentation of RNA/DNA hybrids|
L Di, Y Fu, Y Sun, J Li, L Liu, J Yao, G Wang, Y Wu, K Lao, RW Lee, ...
Proceedings of the National Academy of Sciences 117 (6), 2886-2893, 2020
|Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry|
G Wang, RR Abzalimov, CE Bobst, IA Kaltashov
Proceedings of the National Academy of Sciences 110 (50), 20087-20092, 2013
|Unraveling the macromolecular pathways of IgG oligomerization and complement activation on antigenic surfaces|
J Strasser, RN de Jong, FJ Beurskens, G Wang, AJR Heck, J Schuurman, ...
Nano letters 19 (7), 4787-4796, 2019
|TREM-1 multimerization is essential for its activation on monocytes and neutrophils|
K Carrasco, A Boufenzer, L Jolly, H Le Cordier, G Wang, AJR Heck, ...
Cellular & molecular immunology 16 (5), 460-472, 2019
|Quintets of uracil and thymine: a novel structure of nucleobase self-assembly studied by electrospray ionization mass spectrometry|
B Qiu, J Liu, Z Qin, G Wang, H Luo
Chemical communications, 2863-2865, 2009
|High resolution capillary isoelectric focusing mass spectrometry analysis of peptides, proteins, and monoclonal antibodies with a flow-through microvial interface|
L Wang, T Bo, Z Zhang, G Wang, W Tong, D Da Yong Chen
Analytical chemistry 90 (15), 9495-9503, 2018
|Approach to characterization of the higher order structure of disulfide-containing proteins using hydrogen/deuterium exchange and top-down mass spectrometry|
G Wang, IA Kaltashov
Analytical chemistry 86 (15), 7293–7298, 2014
|Enhancing accuracy in molecular weight determination of highly heterogeneously glycosylated proteins by native tandem mass spectrometry|
G Wang, RN de Jong, ETJ van den Bremer, PWHI Parren, AJR Heck
Analytical chemistry 89 (9), 4793-4797, 2017
|How can native mass spectrometry contribute to characterization of biomacromolecular higher-order structure and interactions?|
W Tong, G Wang
Methods 144, 3-13, 2018
|Molecular survey and characterization of Theileria annulata and Ehrlichia ruminantium in cattle from Northwest China|
H Guo, C Yin, EM Galon, J Du, Y Gao, PFA Moumouni, M Liu, A Efstratiou, ...
Parasitology international 67 (6), 679-683, 2018
|Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry|
G Wang, PV Bondarenko, IA Kaltashov
Analyst 143 (3), 670-677, 2018
|Expression and characterization of recombinant chicken mannose binding lectin|
EJAV Weidong Zhang, Martin van Eijk, Hongbo Guo, Albert van Dijk, Onno B ...
Immunobiology 222 (3), 518–528, 2017
|Differential hydrogen/deuterium exchange during proteoform separation enables characterization of conformational differences between coexisting protein states|
Y Shen, X Zhao, G Wang, DDY Chen
Analytical chemistry 91 (6), 3805-3809, 2019