| Treatment-induced tumor dormancy through YAP-mediated transcriptional reprogramming of the apoptotic pathway KJ Kurppa, Y Liu, C To, T Zhang, M Fan, A Vajdi, EH Knelson, Y Xie, ... Cancer cell 37 (1), 104-122. e12, 2020 | 320 | 2020 |
| CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation M Krajewska, R Dries, AV Grassetti, S Dust, Y Gao, H Huang, B Sharma, ... Nature communications 10 (1), 1757, 2019 | 193 | 2019 |
| Chemically induced degradation of anaplastic lymphoma kinase (ALK) CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ... Journal of medicinal chemistry 61 (9), 4249-4255, 2018 | 181 | 2018 |
| BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells DN Debruyne, R Dries, S Sengupta, D Seruggia, Y Gao, B Sharma, ... Nature 572 (7771), 676-680, 2019 | 99 | 2019 |
| Discovery and resistance mechanism of a selective CDK12 degrader B Jiang, Y Gao, J Che, W Lu, IH Kaltheuner, R Dries, M Kalocsay, ... Nature chemical biology 17 (6), 675-683, 2021 | 77 | 2021 |
| Chemical perturbation of Mcl-1 pre-mRNA splicing to induce apoptosis in cancer cells Y Gao, K Koide ACS chemical biology 8 (5), 895-900, 2013 | 73 | 2013 |
| Overcoming resistance to the THZ series of covalent transcriptional CDK inhibitors Y Gao, T Zhang, H Terai, SB Ficarro, N Kwiatkowski, MF Hao, B Sharma, ... Cell chemical biology 25 (2), 135-142. e5, 2018 | 68 | 2018 |
| Comparison of splicing factor 3b inhibitors in human cells. Y Gao, A Vogt, CJ Forsyth, K Koide Chembiochem: a European journal of chemical biology 14 (1), 49-52, 2012 | 48 | 2012 |
| Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer c Y Gao, S Trevidi, R Ferris, K Koide Scientific Reports 4, 2014 | 45 | 2014 |
| Discovery of inhibitors that overcome the G1202R anaplastic lymphoma kinase resistance mutation JM Hatcher, M Bahcall, HG Choi, Y Gao, T Sim, R George, PA Jänne, ... Journal of medicinal chemistry 58 (23), 9296-9308, 2015 | 44 | 2015 |
| Discovery of MFH290: a potent and highly selective covalent inhibitor for cyclin-dependent kinase 12/13 Y Liu, M Hao, AL Leggett, Y Gao, SB Ficarro, J Che, Z He, CM Olson, ... Journal of Medicinal Chemistry 63 (13), 6708-6726, 2020 | 28 | 2020 |
| Total Synthesis of Lapidilectine B Enabled by Manganese (III)‐Mediated Oxidative Cyclization of Indoles Y Gao, M Fan, Q Geng, D Ma Chemistry–A European Journal 24 (25), 6547-6550, 2018 | 28 | 2018 |
| Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling M Fan, W Lu, J Che, NP Kwiatkowski, Y Gao, HS Seo, SB Ficarro, ... Elife 11, e78810, 2022 | 25 | 2022 |
| Synergistic anti-tumor effect of combining selective CDK7 and BRD4 inhibition in neuroblastoma Y Gao, M Volegova, N Nasholm, S Das, N Kwiatkowski, BJ Abraham, ... Frontiers in Oncology 11, 773186, 2022 | 13 | 2022 |
| Discovery of covalent MKK4/7 dual inhibitor J Jiang, B Jiang, Z He, SB Ficarro, J Che, JA Marto, Y Gao, T Zhang, ... Cell Chemical Biology 27 (12), 1553-1560. e8, 2020 | 12 | 2020 |
| Catalytic degraders effectively address kinase site mutations in EML4-ALK oncogenic fusions Y Gao, B Jiang, H Kim, MJ Berberich, J Che, KA Donovan, JM Hatcher, ... Journal of Medicinal Chemistry 66 (8), 5524-5535, 2023 | 11 | 2023 |
| Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1 W Lu, Y Liu, Y Gao, Q Geng, D Gurbani, L Li, SB Ficarro, CJ Meyer, ... Journal of Medicinal Chemistry 66 (5), 3356-3371, 2023 | 6 | 2023 |
| Abstract B165: Optimizing selective CDK7 inhibition in MYCN-driven neuroblastoma Y Gao, Y Liang, T Zhang, NS Gray, RE George Molecular Cancer Therapeutics 14 (12_Supplement_2), B165-B165, 2015 | 5 | 2015 |
| Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter Y Gao, S Osman, K Koide ACS Medicinal Chemistry Letters 5 (8), 863-867, 2014 | 5 | 2014 |
| Synthesis and Structure–Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold Z Li, R Ishida, Y Liu, J Wang, Y Li, Y Gao, J Jiang, J Che, JM Sheltzer, ... European journal of medicinal chemistry 238, 114433, 2022 | 3 | 2022 |
