Leah E. Cowen
Leah E. Cowen
Vice-President, Research & Innovation, & Strategic Initiatives, University of Toronto
Verified email at - Homepage
Cited by
Cited by
Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi
LE Cowen, S Lindquist
Science 309 (5744), 2185-2189, 2005
Regulatory circuitry governing fungal development, drug resistance, and disease
RS Shapiro, N Robbins, LE Cowen
Microbiology and molecular biology reviews 75 (2), 213-267, 2011
Mechanisms of antifungal drug resistance
LE Cowen, D Sanglard, SJ Howard, PD Rogers, DS Perlin
Cold Spring Harbor perspectives in medicine 5 (7), a019752, 2015
Antifungal drug resistance: evolution, mechanisms and impact
NM Revie, KR Iyer, N Robbins, LE Cowen
Current opinion in microbiology 45, 70-76, 2018
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
LE Cowen, SD Singh, JR Köhler, C Collins, AK Zaas, WA Schell, H Aziz, ...
Proceedings of the National Academy of Sciences 106 (8), 2818-2823, 2009
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Y Lee, E Puumala, N Robbins, LE Cowen
Chemical reviews 121 (6), 3390-3411, 2020
The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype
LE Cowen
Nature Reviews Microbiology 6 (3), 187-198, 2008
Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin
SD Singh, N Robbins, AK Zaas, WA Schell, JR Perfect, LE Cowen
PLoS pathogens 5 (7), e1000532, 2009
Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance
LE Cowen, WJ Steinbach
Eukaryotic cell 7 (5), 747-764, 2008
Molecular evolution of antifungal drug resistance
N Robbins, T Caplan, LE Cowen
Annual review of microbiology 71, 753-775, 2017
Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance
AM Selmecki, K Dulmage, LE Cowen, JB Anderson, J Berman
PLoS genetics 5 (10), e1000705, 2009
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
RS Shapiro, P Uppuluri, AK Zaas, C Collins, H Senn, JR Perfect, ...
Current Biology 19 (8), 621-629, 2009
PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90
SL LaFayette, C Collins, AK Zaas, WA Schell, M Betancourt-Quiroz, ...
PLoS pathogens 6 (8), e1001069, 2010
Threats posed by the fungal kingdom to humans, wildlife, and agriculture
MC Fisher, SJ Gurr, CA Cuomo, DS Blehert, H Jin, EH Stukenbrock, ...
MBio 11 (3), 10.1128/mbio. 00449-20, 2020
Hsp90 governs dispersion and drug resistance of fungal biofilms
N Robbins, P Uppuluri, J Nett, R Rajendran, G Ramage, JL Lopez-Ribot, ...
PLoS pathogens 7 (9), e1002257, 2011
Evolution of Drug Resistance in Experimental Populations of Candida albicans
LE Cowen, D Sanglard, D Calabrese, C Sirjusingh, JB Anderson, ...
Journal of bacteriology 182 (6), 1515-1522, 2000
Global gene deletion analysis exploring yeast filamentous growth
O Ryan, RS Shapiro, CF Kurat, D Mayhew, A Baryshnikova, B Chin, ...
Science 337 (6100), 1353-1356, 2012
Antifungal drugs: the current armamentarium and development of new agents
N Robbins, GD Wright, LE Cowen
Microbiology spectrum 4 (5), 10.1128/microbiolspec. funk-0002-2016, 2016
Global analysis of fungal morphology exposes mechanisms of host cell escape
TR O’Meara, AO Veri, T Ketela, B Jiang, T Roemer, LE Cowen
Nature communications 6 (1), 6741, 2015
Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata
SD Singh-Babak, T Babak, S Diezmann, JA Hill, JL Xie, YL Chen, ...
PLoS pathogens 8 (5), e1002718, 2012
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