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Matthew Welsch
Matthew Welsch
Kleo Pharmaceuticals
Adresse e-mail validée de kleopharmaceuticals.com
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Regulation of ferroptotic cancer cell death by GPX4
WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ...
Cell 156 (1), 317-331, 2014
47952014
Privileged scaffolds for library design and drug discovery
ME Welsch, SA Snyder, BR Stockwell
Current opinion in chemical biology 14 (3), 347-361, 2010
15882010
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
SJ Dixon, DN Patel, M Welsch, R Skouta, ED Lee, M Hayano, AG Thomas, ...
elife 3, e02523, 2014
15292014
Multivalent small-molecule pan-RAS inhibitors
ME Welsch, A Kaplan, JM Chambers, ME Stokes, PH Bos, A Zask, ...
Cell 168 (5), 878-889. e29, 2017
2562017
Modulatory profiling identifies mechanisms of small molecule-induced cell death
AJ Wolpaw, K Shimada, R Skouta, ME Welsch, UD Akavia, D Pe'er, ...
Proceedings of the National Academy of Sciences 108 (39), E771-E780, 2011
1412011
Mild and Direct C–H Arylation of Quinoxalin-2 (1H)-ones with Aryldiazonium Salts under Metal-Free Conditions
K Yin, R Zhang
Synlett 29 (05), 597-602, 2018
442018
Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design
ME Welsch, J Zhou, Y Gao, Y Yan, G Porter, G Agnihotri, Y Li, H Lu, ...
ACS Medicinal Chemistry Letters 7 (12), 1124-1129, 2016
282016
Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use
BR Stockwell, M Welsch, WS Yang
US Patent 9,695,133, 2017
242017
Small molecule that reverses dexamethasone resistance in T-cell acute lymphoblastic leukemia (T-ALL)
AM Cantley, M Welsch, A Ambesi-Impiombato, M Sanchez-Martin, ...
ACS Medicinal Chemistry Letters 5 (7), 754-759, 2014
172014
A green, scalable, one-minute synthesis of benzimidazoles
V Elumalai, JH Hansen
Synlett 31 (06), 547-552, 2020
132020
A metal-free approach for brønsted acid promoted C–H alkylation of heteroarenes with alkyl peroxides
Y Zeng, B Qian, Y Li, H Bao
Synthesis 50 (16), 3250-3256, 2018
112018
From bioactive pyrrolidino [3, 4-c] pyrrolidines to more bioactive pyrrolidino [3, 4-b] pyrrolidines via ring-opening/ring-closing promoted by sodium methoxide
S Belveren, O Larranaga, S Poyraz, HA Dondas, M Ülger, E Şahin, ...
Synthesis 51 (07), 1565-1577, 2019
82019
One-Pot Coupling–Cyclization–Alkylation Synthesis of 1, 2, 5-Trisubstituted 7-Azaindoles in a Consecutive Three-component Fashion
T Lessing, TJJ Mueller
Synlett 28 (14), 1743-1747, 2017
72017
Organocatalytic Gram-Scale Synthesis and Alkylation of Heteroaryl and Electron-Rich Aryl α-Substituted γ-Lactones
M Bos, F Buttard, A Vallée, E Riguet
Synthesis 51 (16), 3151-3159, 2019
62019
Catalyst-Free Synthesis of Aminals from Indole-Derived α, α-Dicyanoolefins
HL Cui, Y Shi, HQ Deng, JJ Lei, XJ Xu, X Tian, J Qiao, L Zhou
Synlett 30 (02), 167-172, 2019
62019
A Convenient One-pot Synthesis of Chromenyl Acrylates and Acrylonitriles
D Lopes, M Costa, J Loucano, F Proenca
Synlett 31 (13), 1298-1302, 2020
42020
Diethylzinc-Mediated Metalloamination–Alkylation of N, N-Dimethylhydrazinoalkenes. Catalysis of C–Zn Alkylation Using Simple Cu (I) Salts
K Mickelsen, S Zabawa, T Livinghouse
Synlett 29 (02), 181-184, 2018
42018
A novel class of bifunctional immunotherapeutic that exploits a universal antibody binding terminus (Uabt) to recruit endogenous antibodies to cell expressing Cd38 demonstrate …
A Bunin, K McGrath, AM Rossi, M Welsch, C Vidal, D Trinh, D Spiegel, ...
Blood 134, 1820, 2019
32019
A first-in-class ex vivo combination between cytokine-induced memory like (CIML) NK cells and a CD38 targeting antibody recruiting molecule (ARM) as a novel approach to target …
L Rastelli, M Mohsin, AM Rossi, E Alvarez Sotomayor, L Iben, A Vaill, ...
Journal of Clinical Oncology 38 (15_suppl), 8523-8523, 2020
22020
Compositions and methods for treating infections
SB Thomas, AT Hopper, M Welsch
US Patent 10,774,073, 2020
12020
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