Anders Poulsen
Anders Poulsen
Experimental Therapeutic Centre
Verified email at etc.a-star.edu.sg - Homepage
Title
Cited by
Cited by
Year
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
S Hart, KC Goh, V Novotny-Diermayr, CY Hu, H Hentze, YC Tan, B Madan, ...
Leukemia 25 (11), 1751-1759, 2011
1592011
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
VM Nayagam, X Wang, YC Tan, A Poulsen, KC Goh, T Ng, H Wang, ...
Journal of biomolecular screening 11 (8), 959-967, 2006
1552006
Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14, 19-dioxa-5, 7, 26-triaza-tetracyclo [19.3. 1.1 (2, 6). 1 (8, 12)] heptacosa-1 (25), 2 (26), 3, 5, 8, 10, 12 (27 …
AD William, ACH Lee, S Blanchard, A Poulsen, EL Teo, H Nagaraj, E Tan, ...
Journal of medicinal chemistry 54 (13), 4638-4658, 2011
1242011
Targeting the central pocket in human transcription factor TEAD as a potential cancer therapeutic strategy
AV Pobbati, X Han, AW Hung, S Weiguang, N Huda, GY Chen, CB Kang, ...
Structure 23 (11), 2076-2086, 2015
742015
Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a …
H Wang, N Yu, D Chen, KCL Lee, PL Lye, JWW Chang, W Deng, MCY Ng, ...
Journal of medicinal chemistry 54 (13), 4694-4720, 2011
722011
Fragment-based ligand design of novel potent inhibitors of tankyrases
EA Larsson, A Jansson, FM Ng, SW Then, R Panicker, B Liu, ...
Journal of medicinal chemistry 56 (11), 4497-4508, 2013
672013
Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9 …
AD William, ACH Lee, KC Goh, S Blanchard, A Poulsen, EL Teo, ...
Journal of medicinal chemistry 55 (1), 169-196, 2012
572012
Combining the [2, 3] sigmatropic rearrangement and ring-closing metathesis strategies for the synthesis of spirocyclic alkaloids. A short and efficient route to …
D Tanner, L Hagberg, A Poulsen
Tetrahedron 55 (5), 1427-1440, 1999
421999
Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria
W Moreira, GJY Ngan, JL Low, A Poulsen, BCS Chia, MJY Ang, A Yap, ...
MBio 6 (3), 2015
412015
Design and synthesis of janus kinase 2 (JAK2) and histone deacetlyase (HDAC) bispecific inhibitors based on pacritinib and evidence of dual pathway inhibition in hematological …
EG Yang, N Mustafa, EC Tan, A Poulsen, PM Ramanujulu, WJ Chng, ...
Journal of medicinal chemistry 59 (18), 8233-8262, 2016
402016
Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 …
A Poulsen, A William, S Blanchard, A Lee, H Nagaraj, H Wang, E Teo, ...
Journal of computer-aided molecular design 26 (4), 437-450, 2012
382012
Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17 …
AD William, ACH Lee, A Poulsen, KC Goh, B Madan, S Hart, E Tan, ...
Journal of medicinal chemistry 55 (6), 2623-2640, 2012
382012
Design and synthesis of ligand efficient dual inhibitors of janus kinase (JAK) and histone deacetylase (HDAC) based on ruxolitinib and vorinostat
L Yao, N Mustafa, EC Tan, A Poulsen, P Singh, MD Duong-Thi, JXT Lee, ...
Journal of Medicinal Chemistry 60 (20), 8336-8357, 2017
332017
Discovery and optimization of a porcupine inhibitor
AJ Duraiswamy, MA Lee, B Madan, SH Ang, ESW Tan, WWV Cheong, ...
Journal of medicinal chemistry 58 (15), 5889-5899, 2015
312015
Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs …
A Poulsen, A William, S Blanchard, H Nagaraj, M Williams, H Wang, ...
Journal of molecular modeling 19 (1), 119-130, 2013
272013
Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex
W Zhang, SP Neo, J Gunaratne, A Poulsen, L Boping, EH Ong, ...
Cellular signalling 27 (3), 436-442, 2015
262015
Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques
X Koh-Stenta, J Joy, A Poulsen, R Li, Y Tan, Y Shim, JH Min, L Wu, A Ngo, ...
Biochemical Journal 461 (2), 323-334, 2014
262014
Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques
X Koh-Stenta, J Joy, A Poulsen, R Li, Y Tan, Y Shim, JH Min, L Wu, A Ngo, ...
Biochemical Journal 461 (2), 323-334, 2014
262014
Exploring the binding of peptidic West Nile virus NS2B–NS3 protease inhibitors by NMR
CB Kang, S Gayen, W Wang, R Severin, AS Chen, HA Lim, CSB Chia, ...
Antiviral research 97 (2), 137-144, 2013
252013
N-Hydroxy-1, 2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity
H Wang, N Yu, H Song, D Chen, Y Zou, W Deng, PL Lye, J Chang, M Ng, ...
Bioorganic & medicinal chemistry letters 19 (5), 1403-1408, 2009
232009
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