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Tim Dafforn
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Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer
TJ Knowles, R Finka, C Smith, YP Lin, T Dafforn, M Overduin
Journal of the American Chemical Society 131 (22), 7484-7485, 2009
5102009
A method for detergent-free isolation of membrane proteins in their local lipid environment
SC Lee, TJ Knowles, VLG Postis, M Jamshad, RA Parslow, YP Lin, ...
Nature protocols 11 (7), 1149-1162, 2016
3382016
Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: the power of native nanodiscs
JM Dörr, MC Koorengevel, M Schäfer, AV Prokofyev, S Scheidelaar, ...
Proceedings of the National Academy of Sciences 111 (52), 18607-18612, 2014
3372014
A structural explanation for the binding of multiple ligands by the α-adaptin appendage domain
DJ Owen, Y Vallis, MEM Noble, JB Hunter, TR Dafforn, PR Evans, ...
Cell 97 (6), 805-815, 1999
3351999
Linear dichroism and circular dichroism: a textbook on polarized-light spectroscopy
B Nordén, A Rodger, T Dafforn
Royal Society of Chemistry, 2019
2972019
Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53
TH Millard, G Bompard, MY Heung, TR Dafforn, DJ Scott, LM Machesky, ...
The EMBO journal 24 (2), 240-250, 2005
2682005
A kinetic mechanism for the polymerization of α1-antitrypsin
TR Dafforn, R Mahadeva, PR Elliott, P Sivasothy, DA Lomas
Journal of Biological Chemistry 274 (14), 9548-9555, 1999
2591999
Detergent-free purification of ABC (ATP-binding-cassette) transporters
S Gulati, M Jamshad, TJ Knowles, KA Morrison, R Downing, N Cant, ...
Biochemical Journal 461 (2), 269-278, 2014
2172014
Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum
T Laursen, J Borch, C Knudsen, K Bavishi, F Torta, HJ Martens, ...
Science 354 (6314), 890-893, 2016
2122016
Topography of a 2.0 Ĺ structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease
PR Elliott, XY Pei, TR Dafforn, DA Lomas
Protein Science 9 (7), 1274-1281, 2000
2122000
Inactive conformation of the serpin α1-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational …
B Gooptu, B Hazes, WSW Chang, TR Dafforn, RW Carrell, RJ Read, ...
Proceedings of the National Academy of Sciences 97 (1), 67-72, 2000
2112000
Heteropolymerization of S, I, and Z α1-antitrypsin and liver cirrhosis
R Mahadeva, WSW Chang, TR Dafforn, DJ Oakley, RC Foreman, J Calvin, ...
The Journal of clinical investigation 103 (7), 999-1006, 1999
2021999
Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins
M Jamshad, V Grimard, I Idini, TJ Knowles, MR Dowle, N Schofield, ...
Nano Research 8 (3), 774-789, 2015
1972015
The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy
V Postis, S Rawson, JK Mitchell, SC Lee, RA Parslow, TR Dafforn, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1848 (2), 496-501, 2015
1952015
6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization: implications for the prevention of Z α1-antitrypsin-related cirrhosis
R Mahadeva, TR Dafforn, RW Carrell, DA Lomas
Journal of Biological Chemistry 277 (9), 6771-6774, 2002
1852002
G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent
M Jamshad, J Charlton, YP Lin, SJ Routledge, Z Bawa, TJ Knowles, ...
Bioscience reports 35 (2), 2015
1792015
Pathogenic α1-antitrypsin polymers are formed by reactive loop-β-sheet A linkage
P Sivasothy, TR Dafforn, PGW Gettins, DA Lomas
Journal of Biological Chemistry 275 (43), 33663-33668, 2000
1602000
Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody
PA Smethurst, L Joutsi-Korhonen, MN O'Connor, E Wilson, NS Jennings, ...
Blood 103 (3), 903-911, 2004
1592004
The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis
TR Dafforn, M Della, AD Miller
Journal of Biological Chemistry 276 (52), 49310-49319, 2001
1492001
Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation
NJ Beauchamp, RN Pike, M Daly, L Butler, M Makris, TR Dafforn, A Zhou, ...
Blood, The Journal of the American Society of Hematology 92 (8), 2696-2706, 1998
1241998
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