| Allosteric control of an ionotropic glutamate receptor with an optical switch M Volgraf, P Gorostiza, R Numano, RH Kramer, EY Isacoff, D Trauner Nature chemical biology 2 (1), 47-52, 2006 | 704 | 2006 |
| Remote control of neuronal activity with a light-gated glutamate receptor S Szobota, P Gorostiza, F Del Bene, C Wyart, DL Fortin, KD Kolstad, ... Neuron 54 (4), 535-545, 2007 | 390 | 2007 |
| Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor P Gorostiza, M Volgraf, R Numano, S Szobota, D Trauner, EY Isacoff Proceedings of the National Academy of Sciences 104 (26), 10865-10870, 2007 | 214 | 2007 |
| Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors M Volgraf, P Gorostiza, S Szobota, MR Helix, EY Isacoff, D Trauner Journal of the American Chemical Society 129 (2), 260-261, 2007 | 199 | 2007 |
| Engineering light-gated ion channels MR Banghart, M Volgraf, D Trauner Biochemistry 45 (51), 15129-15141, 2006 | 160 | 2006 |
| Positive allosteric modulators of GluN2A-containing NMDARs with distinct modes of action and impacts on circuit function DH Hackos, PJ Lupardus, T Grand, Y Chen, TM Wang, P Reynen, ... Neuron 89 (5), 983-999, 2016 | 156 | 2016 |
| Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR R Numano, S Szobota, AY Lau, P Gorostiza, M Volgraf, B Roux, ... Proceedings of the National Academy of Sciences 106 (16), 6814-6819, 2009 | 97 | 2009 |
| Discovery of GluN2A-selective NMDA receptor positive allosteric modulators (PAMs): tuning deactivation kinetics via structure-based design M Volgraf, BD Sellers, Y Jiang, G Wu, CQ Ly, E Villemure, RM Pastor, ... Journal of medicinal chemistry 59 (6), 2760-2779, 2016 | 96 | 2016 |
| All optical interface for parallel, remote, and spatiotemporal control of neuronal activity S Wang, S Szobota, Y Wang, M Volgraf, Z Liu, C Sun, D Trauner, ... Nano letters 7 (12), 3859-3863, 2007 | 84 | 2007 |
| A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment A Balestrini, V Joseph, M Dourado, RM Reese, SD Shields, L Rougé, ... Journal of Experimental Medicine 218 (4), 2021 | 72 | 2021 |
| Biomimetic synthesis of the IDO inhibitors exiguamine A and B M Volgraf, JP Lumb, HC Brastianos, G Carr, MKW Chung, M Münzel, ... Nature Chemical Biology 4 (9), 535-537, 2008 | 68 | 2008 |
| Ligand binding at the protein–lipid interface: strategic considerations for drug design J Payandeh, M Volgraf Nature Reviews Drug Discovery 20 (9), 710-722, 2021 | 64 | 2021 |
| GluN2A NMDA receptor enhancement improves brain oscillations, synchrony, and cognitive functions in Dravet syndrome and Alzheimer’s disease models JE Hanson, K Ma, J Elstrott, M Weber, S Saillet, AS Khan, J Simms, B Liu, ... Cell reports 30 (2), 381-396. e4, 2020 | 63 | 2020 |
| A non-covalent ligand reveals biased agonism of the TRPA1 ion channel C Liu, R Reese, S Vu, L Rougé, SD Shields, S Kakiuchi-Kiyota, H Chen, ... Neuron 109 (2), 273-284. e4, 2021 | 60 | 2021 |
| Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system AA Thomas, KW Hunt, M Volgraf, RJ Watts, X Liu, G Vigers, D Smith, ... Journal of Medicinal Chemistry 57 (3), 878-902, 2014 | 45 | 2014 |
| Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug … H Chen, M Volgraf, S Do, A Kolesnikov, DG Shore, VA Verma, E Villemure, ... Journal of Medicinal Chemistry 61 (8), 3641-3659, 2018 | 39 | 2018 |
| GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile E Villemure, M Volgraf, Y Jiang, G Wu, CQ Ly, P Yuen, A Lu, X Luo, M Liu, ... ACS Medicinal Chemistry Letters 8 (1), 84-89, 2017 | 36 | 2017 |
| Total synthesis of exiguamines A and B inspired by catecholamine chemistry V Sofiyev, JP Lumb, M Volgraf, D Trauner Chemistry–A European Journal 18 (16), 4999-5005, 2012 | 36 | 2012 |
| A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain TM Wang, BM Brown, L Deng, BD Sellers, PJ Lupardus, HJA Wallweber, ... Neuropharmacology 121, 204-218, 2017 | 31 | 2017 |
| Discovery of 5-azaindazole (GNE-955) as a potent pan-Pim inhibitor with optimized bioavailability X Wang, A Kolesnikov, S Tay, G Chan, Q Chao, S Do, J Drummond, ... Journal of Medicinal Chemistry 60 (10), 4458-4473, 2017 | 28 | 2017 |
