Jonathan D Ashwell
Jonathan D Ashwell
Principal Investigator, National Institutes of Health
Verified email at
Cited by
Cited by
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
Y Yang, S Fang, JP Jensen, AM Weissman, JD Ashwell
Science 288 (5467), 874-877, 2000
Glucocorticoids in T cell development and function
JD Ashwell, FWM Lu, MS Vacchio
Annual review of immunology 18 (1), 309-345, 2000
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation
CJ Wu, DB Conze, T Li, SM Srinivasula, JD Ashwell
Nature cell biology 8 (4), 398-406, 2006
IAPs: what's in a name?
SM Srinivasula, JD Ashwell
Molecular cell 30 (2), 123-135, 2008
Outer membrane vesicles of a human commensal mediate immune regulation and disease protection
Y Shen, MLG Torchia, GW Lawson, CL Karp, JD Ashwell, SK Mazmanian
Cell host & microbe 12 (4), 509-520, 2012
Genomic instability in Gadd45a-deficient mice
MC Hollander, MS Sheikh, DV Bulavin, K Lundgren, L Augeri-Henmueller, ...
Nature genetics 23 (2), 176-184, 1999
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
X Li, Y Yang, JD Ashwell
Nature 416 (6878), 345-347, 2002
The many paths to p38 mitogen-activated protein kinase activation in the immune system
JD Ashwell
Nature Reviews Immunology 6 (7), 532-540, 2006
Failure to synthesize the T cell CD3-ζ chain: structure and function of a partial T cell receptor complex
JJ Sussman, JS Bonifacino, J Lippincott-Schwartz, AM Weissman, T Saito, ...
Cell 52 (1), 85-95, 1988
Steroid production in the thymus: implications for thymocyte selection.
MS Vacchio, V Papadopoulos, JD Ashwell
The Journal of experimental medicine 179 (6), 1835-1846, 1994
Programmed T lymphocyte death. Cell activation-and steroid-induced pathways are mutually antagonistic.
CM Zacharchuk, M Merćep, PK Chakraborti, SS Simons Jr, JD Ashwell
Journal of immunology (Baltimore, Md.: 1950) 145 (12), 4037-4045, 1990
Genetic and mutational analysis of the T-cell antigen receptor
JD Ashwell, RD Klausner
Annual review of immunology 8 (1), 139-167, 1990
Alternative p38 activation pathway mediated by T cell receptor–proximal tyrosine kinases
JM Salvador, PR Mittelstadt, T Guszczynski, TD Copeland, H Yamaguchi, ...
Nature immunology 6 (4), 390-395, 2005
Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.
MK Jenkins, JD Ashwell, RH Schwartz
Journal of immunology (Baltimore, Md.: 1950) 140 (10), 3324-3330, 1988
Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ
PR Mittelstadt, JD Ashwell
Journal of Biological Chemistry 276 (31), 29603-29610, 2001
Optineurin negatively regulates TNFα-induced NF-κB activation by competing with NEMO for ubiquitinated RIP
G Zhu, CJ Wu, Y Zhao, JD Ashwell
Current Biology 17 (16), 1438-1443, 2007
Cell growth cycle block of T cell hybridomas upon activation with antigen.
JD Ashwell, RE Cunningham, PD Noguchi, D Hernandez
The Journal of experimental medicine 165 (1), 173-194, 1987
Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis
JM Lenczowski, L Domínguez, AM Eder, LB King, CM Zacharchuk, ...
Molecular and cellular biology, 1997
Structural basis for recognition of diubiquitins by NEMO
YC Lo, SC Lin, CC Rospigliosi, DB Conze, CJ Wu, JD Ashwell, D Eliezer, ...
Molecular cell 33 (5), 602-615, 2009
Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor-and toll-like receptor-mediated NF-κB activation
DB Conze, CJ Wu, JA Thomas, A Landstrom, JD Ashwell
Molecular and cellular biology 28 (10), 3538-3547, 2008
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