Maria Themeli
Maria Themeli
Assistant Professor, Amsterdam UMC
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PD-1–and CTLA-4–based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses
VD Fedorov, M Themeli, M Sadelain
Science translational medicine 5 (215), 215ra172-215ra172, 2013
Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
M Themeli, CC Kloss, G Ciriello, VD Fedorov, F Perna, M Gonen, ...
Nature biotechnology 31 (10), 928-933, 2013
A rational strategy for reducing on-target off-tumor effects of CD38-chimeric antigen receptors by affinity optimization
E Drent, M Themeli, R Poels, R de Jong-Korlaar, H Yuan, J de Bruijn, ...
Molecular therapy 25 (8), 1946-1958, 2017
New cell sources for T cell engineering and adoptive immunotherapy
M Themeli, I Rivière, M Sadelain
Cell stem cell 16 (4), 357-366, 2015
Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma
E Drent, RWJ Groen, WA Noort, M Themeli, JJL van Bueren, PWHI Parren, ...
haematologica 101 (5), 616, 2016
Combined CD28 and 4-1BB costimulation potentiates affinity-tuned chimeric antigen receptor–Engineered T cells
E Drent, R Poels, R Ruiter, NWCJ van de Donk, S Zweegman, H Yuan, ...
Clinical Cancer Research 25 (13), 4014-4025, 2019
Detection of alpha-thalassemia in beta-thalassemia carriers and prevention of Hb Bart's hydrops fetalis through prenatal screening
D Li, C Liao, J Li, X Xie, Y Huang, H Zhong
haematologica 91 (5), 649-651, 2006
CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia
J Naik, M Themeli, R de Jong-Korlaar, RWJ Ruiter, PJ Poddighe, H Yuan, ...
Haematologica 104 (3), e100, 2019
Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: in vivo and in vitro …
M Themeli, L Petrikkos, M Waterhouse, H Bertz, E Lagadinou, N Zoumbos, ...
Leukemia 24 (3), 536-543, 2010
Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design
E Drent, R Poels, MJ Mulders, NWCJ van de Donk, M Themeli, ...
PloS one 13 (5), e0197349, 2018
CD38-targeting antibodies in multiple myeloma: mechanisms of action and clinical experience
KA Frerichs, NA Nagy, PL Lindenbergh, P Bosman, J Marin Soto, ...
Expert review of clinical immunology 14 (3), 197-206, 2018
Semiconductor substrate, method of manufacturing the same and semiconductor device
M Takenaka, K Fujii
US Patent App. 10/370,452, 2003
Induced pluripotent stem cell (iPSC)–derived lymphocytes for adoptive cell immunotherapy: recent advances and challenges
A Nianias, M Themeli
Current hematologic malignancy reports 14 (4), 261-268, 2019
Horizontal DNA transfer from donor to host cells as an alternative mechanism of epithelial chimerism after allogeneic hematopoietic cell transplantation
M Waterhouse, M Themeli, H Bertz, N Zoumbos, J Finke, A Spyridonidis
Biology of Blood and Marrow Transplantation 17 (3), 319-329, 2011
Pharmacokinetics and clinical activity of very low-dose alemtuzumab in transplantation for acute leukemia
A Spyridonidis, M Liga, E Triantafyllou, M Themeli, M Marangos, ...
Bone marrow transplantation 46 (10), 1363-1368, 2011
Escape mutations, ganciclovir resistance, and teratoma formation in human iPSCs expressing an HSVtk suicide gene
AG Kotini, E De Stanchina, M Themeli, M Sadelain, EP Papapetrou
Molecular Therapy-Nucleic Acids 5, e284, 2016
PD-1-and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. Sci Transl Med. 2013; 5 (215): 215ra172
VD Fedorov, M Themeli, M Sadelain
Nat Biotechnol 31 (1), 71-5, 2013
Identification of a novel HLA-G+ regulatory population in blood: expansion after allogeneic transplantation and de novo HLA-G expression at graft-versus-host disease sites
I Lazana, A Zoudiari, D Kokkinou, M Themeli, M Liga, H Papadaki, ...
Haematologica 97 (9), 1338, 2012
The tumor vasculature an attractive CAR T cell target in solid tumors
P Akbari, EJM Huijbers, M Themeli, AW Griffioen, JR van Beijnum
Angiogenesis 22 (4), 473-475, 2019
Combinatorial antigen targeting: ideal T-cell sensing and anti-tumor response
M Themeli, M Sadelain
Trends in molecular medicine 22 (4), 271-273, 2016
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