Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides AM Kloosterman, P Cimermancic, SS Elsayed, C Du, M Hadjithomas, ... PLoS biology 18 (12), e3001026, 2020 | 106 | 2020 |
Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation Z Zhang, C Du, F de Barsy, M Liem, A Liakopoulos, GP van Wezel, ... Science advances 6 (3), eaay5781, 2020 | 89 | 2020 |
Metabolomics-Driven Discovery of a Prenylated Isatin Antibiotic Produced by Streptomyces Species MBT28 C Wu, C Du, J Gubbens, YH Choi, GP Van Wezel Journal of natural products 78 (10), 2355-2363, 2015 | 74 | 2015 |
iTRAQ-based proteomic analysis of the metabolism mechanism associated with silicon response in the marine diatom Thalassiosira pseudonana C Du, JR Liang, DD Chen, B Xu, WH Zhuo, YH Gao, CP Chen, C Bowler, ... Journal of proteome research 13 (2), 720-734, 2014 | 48 | 2014 |
Mining for microbial gems: integrating proteomics in the postgenomic natural product discovery pipeline C Du, GP van Wezel Proteomics 18 (18), 1700332, 2018 | 44 | 2018 |
Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow C Wu, C Du, K Ichinose, YH Choi, GP Van Wezel Journal of natural products 80 (2), 269-277, 2017 | 43 | 2017 |
Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production S Sulheim, T Kumelj, D van Dissel, A Salehzadeh-Yazdi, C Du, ... Iscience 23 (9), 2020 | 30 | 2020 |
MALDI-TOF MS analysis of the extracellular polysaccharides released by the diatom Thalassiosira pseudonana under various nutrient conditions XX Ai, JR Liang, YH Gao, SCL Lo, FWF Lee, CP Chen, CS Luo, C Du Journal of Applied Phycology 27, 673-684, 2015 | 28 | 2015 |
Discovery of actinomycin L, a new member of the actinomycin family of antibiotics NV Machushynets, SS Elsayed, C Du, MA Siegler, M de la Cruz, ... Scientific Reports 12 (1), 2813, 2022 | 20 | 2022 |
The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces DA van Bergeijk, SS Elsayed, C Du, IN Santiago, AM Roseboom, L Zhang, ... Communications Chemistry 5 (1), 14, 2022 | 19 | 2022 |
Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway X Xiao, SS Elsayed, C Wu, HU van der Heul, M Metsä-Ketelä, C Du, ... ACS chemical biology 15 (9), 2529-2538, 2020 | 9 | 2020 |
System-Wide Analysis of the GATC-Binding Nucleoid-Associated Protein Gbn and Its Impact on Streptomyces Development C Du, J Willemse, AM Erkelens, VJ Carrion, RT Dame, GP van Wezel Msystems 7 (3), e00061-22, 2022 | 5 | 2022 |
Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products AM Kloosterman, P Cimermancic, SS Elsayed, C Du, M Hadjithomas, ... bioRxiv, 2020.05. 19.104752, 2020 | 3 | 2020 |
New from old: discovery of the novel antibiotic actinomycin L in Streptomyces sp. MBT27 N Machushynets, SS Elsayed, C Du, MA Siegler, M de la Cruz, ... BioRxiv, 2021.10. 12.464064, 2021 | 2 | 2021 |
Antibiotic production in Streptomyces is organized by a division of labour through terminal genomic differentiation Z Zhang, C Du, F de Barsy, M Liem, A Liakopoulos, GP van Wezel, ... bioRxiv, 560136, 2019 | 1 | 2019 |
Genomescale model constrained by proteomics reveals metabolic rearrangements in the heterologous host streptomyces coelicolor S Sulheim, T Kumelj, D Van Dissel, A Salehzadeh-Yazdi, C Du, K Nieselt, ... bioRxiv, 2019 | 1 | 2019 |
The cryptic qin gene cluster of Streptomyces sp. MBT76 specifies C-glycosylpyranonaphthoquinones with new chemistry C Wu, C Du, K Ichinose, YH Choi, GP van Wezel Discovery of Novel Antibiotics from Actinomycetes by Integrated Metabolomics …, 1985 | 1 | 1985 |
Adrenaline-mediated activation of antibiotic production in Streptomyces highlights catechol as elicitor of specialized metabolism G van Wezel, D van Bergeijk, S Elsayed, C Du, IN Santiago, A Roseboom, ... | | 2021 |
Adrenaline-mediated activation of antibiotic production in Streptomyces highlights catechol as elicitor of specialized metabolism W Gv, B Dv, S Elsayed, C Du, IN Santiago, A Roseboom, L Zhang, ... | | 2021 |
Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by C Wu, C Du, K Ichinose, YH Choi, GP van Wezel | | |