| Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition M Sciacovelli, E Gonçalves, TI Johnson, VR Zecchini, ASH Da Costa, ... Nature 537 (7621), 544-547, 2016 | 438 | 2016 |
| Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition A Rasola, M Sciacovelli, F Chiara, B Pantic, WS Brusilow, P Bernardi Proceedings of the National Academy of Sciences 107 (2), 726-731, 2010 | 255 | 2010 |
| Fumarate induces redox-dependent senescence by modifying glutathione metabolism L Zheng, S Cardaci, L Jerby, ED MacKenzie, M Sciacovelli, TI Johnson, ... Nature communications 6 (1), 6001, 2015 | 224 | 2015 |
| The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase M Sciacovelli, G Guzzo, V Morello, C Frezza, L Zheng, N Nannini, ... Cell metabolism 17 (6), 988-999, 2013 | 215 | 2013 |
| Metabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer M Sciacovelli, C Frezza The FEBS journal 284 (19), 3132-3144, 2017 | 214 | 2017 |
| Signal transduction to the permeability transition pore A Rasola, M Sciacovelli, B Pantic, P Bernardi FEBS letters 584 (10), 1989-1996, 2010 | 199 | 2010 |
| Oncometabolites: Unconventional triggers of oncogenic signalling cascades M Sciacovelli, C Frezza Free Radical Biology and Medicine 100, 175-181, 2016 | 161 | 2016 |
| Germline FH Mutations Presenting With Pheochromocytoma GR Clark, M Sciacovelli, E Gaude, DM Walsh, G Kirby, MA Simpson, ... The Journal of Clinical Endocrinology & Metabolism 99 (10), E2046-E2050, 2014 | 160 | 2014 |
| The metabolic alterations of cancer cells M Sciacovelli, E Gaude, M Hilvo, C Frezza Methods in enzymology 542, 1-23, 2014 | 114 | 2014 |
| Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death F Chiara, A Gambalunga, M Sciacovelli, A Nicolli, L Ronconi, D Fregona, ... Cell death & disease 3 (12), e444-e444, 2012 | 75 | 2012 |
| Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells G Guzzo, M Sciacovelli, P Bernardi, A Rasola Oncotarget 5 (23), 11897, 2014 | 74 | 2014 |
| Fumarate hydratase in cancer: A multifaceted tumour suppressor C Schmidt, M Sciacovelli, C Frezza Seminars in cell & developmental biology 98, 15-25, 2020 | 73 | 2020 |
| Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses A Dugourd, C Kuppe, M Sciacovelli, E Gjerga, A Gabor, KB Emdal, ... Molecular systems biology 17 (1), e9730, 2021 | 64 | 2021 |
| Fumarate hydratase loss causes combined respiratory chain defects PA Tyrakis, ME Yurkovich, M Sciacovelli, EK Papachristou, HR Bridges, ... Cell reports 21 (4), 1036-1047, 2017 | 57 | 2017 |
| Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore L Azzolin, N Antolini, A Calderan, P Ruzza, M Sciacovelli, O Marin, ... PloS one 6 (1), e16280, 2011 | 57 | 2011 |
| SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I F Ciscato, M Sciacovelli, G Villano, C Turato, P Bernardi, A Rasola, ... Oncotarget 5 (9), 2418, 2014 | 54 | 2014 |
| Mutations in mitochondrial DNA causing tubulointerstitial kidney disease TM Connor, S Hoer, A Mallett, DP Gale, A Gomez-Duran, V Posse, ... PLoS genetics 13 (3), e1006620, 2017 | 50 | 2017 |
| Metabolic drivers in hereditary cancer syndromes M Sciacovelli, C Schmidt, ER Maher, C Frezza Annual Review of Cancer Biology 4, 77-97, 2020 | 31 | 2020 |
| Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells E Gonçalves, M Sciacovelli, ASH Costa, MGB Tran, TI Johnson, ... Metabolic engineering 45, 149-157, 2018 | 25 | 2018 |
| Fumarate drives EMT in renal cancer M Sciacovelli, C Frezza Cell Death and Differentiation 24 (1), 1, 2017 | 22 | 2017 |
Christian FrezzaCECAD, University of CologneVerified email at uni-koeln.de
