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Evelyn Sattlegger
Evelyn Sattlegger
Massey University, New Zealand
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Keeping the eIF2 alpha kinase Gcn2 in check
BA Castilho, R Shanmugam, RC Silva, R Ramesh, BM Himme, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (9), 1948-1968, 2014
2982014
Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid‐starved cells
E Sattlegger, AG Hinnebusch
The EMBO Journal, 2000
1622000
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation
CM Pereira, E Sattlegger, HY Jiang, BM Longo, CB Jaqueta, ...
Journal of Biological Chemistry 280 (31), 28316-28323, 2005
962005
Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2α kinase GCN2 during amino acid starvation
E Sattlegger, AG Hinnebusch
Journal of Biological Chemistry 280 (16), 16514-16521, 2005
962005
cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2α kinase and histidyl-tRNA synthetase-related domains required for general amino …
E Sattlegger, AG Hinnebusch, IB Barthelmess
Journal of Biological Chemistry 273 (32), 20404-20416, 1998
791998
YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed
E Sattlegger, MJ Swanson, EA Ashcraft, JL Jennings, RA Fekete, AJ Link, ...
Journal of Biological Chemistry 279 (29), 29952-29962, 2004
742004
The WD protein Cpc2p is required for repression of Gcn4 protein activity in yeast in the absence of amino‐acid starvation
B Hoffmann, HU Mösch, E Sattlegger, IB Barthelmess, A Hinnebusch, ...
Molecular microbiology 31 (3), 807-822, 1999
591999
Evidence That Eukaryotic Translation Elongation Factor 1A (eEF1A) Binds the Gcn2 Protein C Terminus and Inhibits Gcn2 Activity*♦
J Visweswaraiah, S Lageix, BA Castilho, L Izotova, TG Kinzy, ...
Journal of Biological Chemistry 286 (42), 36568-36579, 2011
572011
Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior
VS Alves, DC Pimenta, E Sattlegger, BA Castilho
Biochemical and biophysical research communications 314 (1), 229-234, 2004
532004
The cpc-2 gene ofNeurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility
F Müller, D Krüger, E Sattlegger, B Hoffmann, P Ballario, M Kanaan, ...
Molecular and General Genetics MGG 248, 162-173, 1995
521995
Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2
E Sattlegger, JARG Barbosa, MCS Moraes, RM Martins, AG Hinnebusch, ...
Journal of Biological Chemistry 286 (12), 10341-10355, 2011
472011
Saccharomyces cerevisiae Rbg1 Protein and Its Binding Partner Gir2 Interact on Polyribosomes with Gcn1
PK Wout, E Sattlegger, SM Sullivan, JR Maddock
Eukaryotic cell 8 (7), 1061-1071, 2009
452009
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response
RC Silva, E Sattlegger, BA Castilho
Journal of Cell Science 129 (24), 4521-4533, 2016
432016
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2
TD Cambiaghi, CM Pereira, R Shanmugam, M Bolech, RC Wek, ...
Biochemical and biophysical research communications 443 (2), 592-597, 2014
412014
Transcriptional defect of an inherited NKX2-5 haplotype comprising a SNP, a nonsynonymous and a synonymous mutation, associated with human congenital heart disease
SM Reamon-Buettner, E Sattlegger, Y Ciribilli, A Inga, A Wessel, J Borlak
PLoS One 8 (12), e83295, 2013
372013
Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation
J Visweswaraiah, SJ Lee, AG Hinnebusch, E Sattlegger
Journal of Biological Chemistry 287 (45), 37757-37768, 2012
272012
Damaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic‐dyskinetic encephalopathy
GL Carvill, KL Helbig, CT Myers, M Scala, R Huether, S Lewis, TN Kruer, ...
Human mutation 41 (7), 1263-1279, 2020
242020
Yeast as a model to understand actin-mediated cellular functions in mammals—illustrated with four actin cytoskeleton proteins
Z Akram, I Ahmed, H Mack, R Kaur, RC Silva, BA Castilho, S Friant, ...
Cells 9 (3), 672, 2020
232020
Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2
SJ Lee, MJ Swanson, E Sattlegger
Biochemical Journal 466 (3), 547-559, 2015
232015
Evidence that Yih1 resides in a complex with ribosomes
T Waller, SJ Lee, E Sattlegger
The FEBS journal 279 (10), 1761-1776, 2012
222012
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