| Chaste: an open source C++ library for computational physiology and biology GR Mirams, CJ Arthurs, MO Bernabeu, R Bordas, J Cooper, A Corrias, ... PLoS computational biology 9 (3), e1002970, 2013 | 526 | 2013 |
| Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk GR Mirams, Y Cui, A Sher, M Fink, J Cooper, BM Heath, NC McMahon, ... Cardiovascular research 91 (1), 53, 2011 | 342 | 2011 |
| Chaste: a test-driven approach to software development for biological modelling J Pitt-Francis, P Pathmanathan, MO Bernabeu, R Bordas, J Cooper, ... Computer Physics Communications 180 (12), 2452-2471, 2009 | 315 | 2009 |
| An integrative computational model for intestinal tissue renewal IMM Van Leeuwen, GR Mirams, A Walter, A Fletcher, P Murray, J Osborne, ... Cell proliferation 42 (5), 617-636, 2009 | 191* | 2009 |
| Uncertainty and variability in computational and mathematical models of cardiac physiology GR Mirams, P Pathmanathan, RA Gray, P Challenor, RH Clayton The Journal of physiology 594 (23), 6833-6847, 2016 | 173 | 2016 |
| Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models? RH Johnstone, ETY Chang, R Bardenet, TP De Boer, DJ Gavaghan, ... Journal of molecular and cellular cardiology 96, 49-62, 2016 | 172 | 2016 |
| Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current I f: Novel electrophysiological insights and therapeutic potential RA Capel, N Herring, M Kalla, A Yavari, GR Mirams, G Douglas, G Bub, ... Heart Rhythm 12 (10), 2186-2194, 2015 | 168 | 2015 |
| Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG MKB Jonsson, MA Vos, GR Mirams, G Duker, P Sartipy, TP de Boer, ... Journal of Molecular and Cellular Cardiology 52 (5), 998-1008, 2012 | 166 | 2012 |
| A hybrid approach to multi-scale modelling of cancer JM Osborne, A Walter, SK Kershaw, GR Mirams, AG Fletcher, ... Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2010 | 157 | 2010 |
| Assessment of an in silico mechanistic model for proarrhythmia risk prediction under the CiPA initiative Z Li, WW Wu, J Sheng, PN Tran, M Wu, A Ranolph, RH Johnstone, ... Clinical Pharmacology & Therapeutics, 2018 | 156 | 2018 |
| A computational study of discrete mechanical tissue models P Pathmanathan, J Cooper, A Fletcher, G Mirams, P Murray, J Osborne, ... Physical biology 6 (3), 036001, 2009 | 150 | 2009 |
| Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials N Zemzemi, MO Bernabeu, J Saiz, J Cooper, P Pathmanathan, ... British Journal of Pharmacology 168 (3), 718-733, 2012 | 129 | 2012 |
| Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing GR Mirams, MR Davies, Y Cui, P Kohl, D Noble British Journal of Pharmacology 167 (5), 932-945, 2012 | 117 | 2012 |
| Systems Toxicology: Real World Applications and Opportunities T Hartung, RE FitzGerald, P Jennings, GR Mirams, MC Peitsch, ... Chemical Research in Toxicology 30 (4), 870, 2017 | 114 | 2017 |
| Calibration of ionic and cellular cardiac electrophysiology models DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams Wiley Interdisciplinary Reviews: Systems Biology and Medicine 12 (4), e1482, 2020 | 111 | 2020 |
| Prediction of Thorough QT study results using action potential simulations based on ion channel screens GR Mirams, MR Davies, SJ Brough, MH Bridgland-Taylor, Y Cui, ... Journal of pharmacological and toxicological methods 70 (3), 246-254, 2014 | 106 | 2014 |
| Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment RC Elkins, MR Davies, SJ Brough, DJ Gavaghan, Y Cui, N Abi-Gerges, ... Journal of pharmacological and toxicological methods 68 (1), 112-122, 2013 | 101 | 2013 |
| Uncertainty quantification reveals the importance of data variability and experimental design considerations for in silico proarrhythmia risk assessment KC Chang, S Dutta, GR Mirams, KA Beattie, J Sheng, PN Tran, M Wu, ... Frontiers in physiology 8, 917, 2017 | 92 | 2017 |
| General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ... Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020 | 91 | 2020 |
| High resolution structural evidence suggests the sarcoplasmic reticulum forms microdomains with acidic stores (lysosomes) in the heart D Aston, RA Capel, KL Ford, HC Christian, GR Mirams, EA Rog-Zielinska, ... Scientific Reports 7, 40620, 2017 | 88 | 2017 |
David GavaghanProfessor of Computational Biology, University of OxfordVerified email at cs.ox.ac.uk
