Roy van der Meel
Roy van der Meel
Assistant Professor, Department of Biomedical Engineering, Eindhoven University of Technology
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Ligand-targeted particulate nanomedicines undergoing clinical evaluation: current status
R van der Meel, LJC Vehmeijer, RJ Kok, G Storm, EVB van Gaal
Advanced Drug Delivery Reviews, 1284-1298, 2013
Extracellular vesicles as drug delivery systems: lessons from the liposome field
R van der Meel, MHAM Fens, P Vader, WW Van Solinge, ...
Journal of Controlled Release 195, 72-85, 2014
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
SAA Kooijmans, LAL Fliervoet, R van der Meel, M Fens, HFG Heijnen, ...
Journal of Controlled Release 224, 77-85, 2016
Smart cancer nanomedicine
R van der Meel, E Sulheim, Y Shi, F Kiessling, WJM Mulder, T Lammers
Nature Nanotechnology 14 (11), 1007-1017, 2019
Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π–Π Stacking Stabilized Polymeric Micelles
Y Shi, R Van Der Meel, B Theek, E Oude Blenke, EHE Pieters, ...
ACS nano 9 (4), 3740-3752, 2015
Downregulation of EGFR by a novel multivalent nanobody-liposome platform
S Oliveira, RM Schiffelers, J van der Veeken, R van der Meel, ...
Journal of Controlled Release 145 (2), 165-175, 2010
Reprint of" Nanobody—Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting"
M Talelli, CJF Rijcken, S Oliveira, R van der Meel, PMPB en Henegouwen, ...
Journal of controlled release 153 (1), 93-102, 2011
Lipid nanoparticles enabling gene therapies: from concepts to clinical utility
JA Kulkarni, PR Cullis, R Van Der Meel
Nucleic acid therapeutics 28 (3), 146-157, 2018
Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment
R Van Der Meel, S Oliveira, I Altintas, R Haselberg, J Van Der Veeken, ...
Journal of controlled release 159 (2), 281-289, 2012
Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells
I Altintas, R Heukers, R van der Meel, M Lacombe, M Amidi, ...
Journal of controlled release 165 (2), 110-118, 2013
Cancer nanomedicines: oversold or underappreciated?
R van der Meel, T Lammers, WE Hennink
Expert Opinion on Drug Delivery 14 (1), 1-5, 2016
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
A Akinc, MA Maier, M Manoharan, K Fitzgerald, M Jayaraman, S Barros, ...
Nature Nanotechnology 14 (12), 1084-1087, 2019
The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy
R van der Meel, MH Symons, R Kudernatsch, RJ Kok, RM Schiffelers, ...
Drug discovery today 16 (5-6), 219-228, 2011
Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies
R van der Meel, WM Gallagher, S Oliveira, AE O’Connor, RM Schiffelers, ...
Drug discovery today 15 (3-4), 102-114, 2010
On the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA
JA Kulkarni, MM Darjuan, JE Mercer, S Chen, R Van Der Meel, ...
ACS nano 12 (5), 4787-4795, 2018
Toward routine detection of extracellular vesicles in clinical samples
R van der Meel, M Krawczyk‐Durka, WW Solinge, RM Schiffelers
International Journal of Laboratory Hematology 36 (3), 244-253, 2014
An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAs
LN Borgheti-Cardoso, LV Depieri, SAA Kooijmans, H Diniz, RAJ Calzzani, ...
European Journal of Pharmaceutical Sciences 74, 103-117, 2015
Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach
P Vader, R Van Der Meel, MH Symons, M Fens, E Pieters, KJ Wilschut, ...
Angiogenesis 14 (4), 457-466, 2011
Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutic
JA Kulkarni, D Witzigmann, S Chen, PR Cullis, R van der Meel
Accounts of Chemical Research 52 (9), 2435 - 2444, 2019
Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles
P Vader, BJ Crielaard, SM Van Dommelen, R Van der Meel, G Storm, ...
Journal of controlled release 160 (2), 211-216, 2012
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