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Marie Didiot
Marie Didiot
Verified email at umassmed.edu
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High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources
RA Haraszti, MC Didiot, E Sapp, J Leszyk, SA Shaffer, HE Rockwell, ...
Journal of extracellular vesicles 5 (1), 32570, 2016
6112016
Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing
MC Didiot, LM Hall, AH Coles, RA Haraszti, BMDC Godinho, K Chase, ...
Molecular Therapy 24 (10), 1836-1847, 2016
4362016
Exosomes produced from 3D cultures of MSCs by tangential flow filtration show higher yield and improved activity
RA Haraszti, R Miller, M Stoppato, YY Sere, A Coles, MC Didiot, ...
Molecular Therapy 26 (12), 2838-2847, 2018
3372018
A novel function for fragile X mental retardation protein in translational activation
EG Bechara, MC Didiot, M Melko, L Davidovic, M Bensaid, P Martin, ...
PLoS biology 7 (1), e1000016, 2009
2422009
The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer
MC Didiot, Z Tian, C Schaeffer, M Subramanian, JL Mandel, H Moine
Nucleic acids research 36 (15), 4902-4912, 2008
2042008
Hydrophobically modified siRNAs silence huntingtin mRNA in primary neurons and mouse brain
JF Alterman, LM Hall, AH Coles, MR Hassler, MC Didiot, K Chase, ...
Molecular Therapy-Nucleic Acids 4, 2015
1442015
Cells lacking the fragile X mental retardation protein (FMRP) have normal RISC activity but exhibit altered stress granule assembly
MC Didiot, M Subramanian, E Flatter, JL Mandel, H Moine
Molecular biology of the cell 20 (1), 428-437, 2009
1242009
Visualization of self-delivering hydrophobically modified siRNA cellular internalization
S Ly, DM Navaroli, MC Didiot, J Cardia, L Pandarinathan, JF Alterman, ...
Nucleic acids research 45 (1), 15-25, 2017
952017
Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles
RA Haraszti, R Miller, MC Didiot, A Biscans, JF Alterman, MR Hassler, ...
Molecular Therapy 26 (8), 1973-1982, 2018
812018
Serum deprivation of mesenchymal stem cells improves exosome activity and alters lipid and protein composition
RA Haraszti, R Miller, ML Dubuke, HE Rockwell, AH Coles, E Sapp, ...
Iscience 16, 230-241, 2019
722019
Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs
MF Osborn, JF Alterman, M Nikan, H Cao, MC Didiot, MR Hassler, ...
Nucleic acids research 43 (18), 8664-8672, 2015
492015
Nuclear localization of huntingtin mRNA is specific to cells of neuronal origin
MC Didiot, CM Ferguson, S Ly, AH Coles, AO Smith, AA Bicknell, LM Hall, ...
Cell reports 24 (10), 2553-2560. e5, 2018
442018
Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles
A Biscans, RA Haraszti, D Echeverria, R Miller, MC Didiot, M Nikan, ...
Molecular Therapy 26 (6), 1520-1528, 2018
382018
Identification of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation
MC Didiot, J Hewett, T Varin, F Freuler, D Selinger, H Nick, J Reinhardt, ...
Journal of biomolecular screening 18 (4), 407-419, 2013
282013
Multiplexed reporter gene assays: monitoring the cell viability and the compound kinetics on luciferase activity
MC Didiot, S Serafini, MJ Pfeifer, FJ King, CN Parker
Journal of biomolecular screening 16 (7), 786-793, 2011
212011
Latent hit series hidden in high-throughput screening data
T Varin, MC Didiot, CN Parker, A Schuffenhauer
Journal of medicinal chemistry 55 (3), 1161-1170, 2012
192012
Loading of extracellular vesicles with hydrophobically modified siRNAs
MC Didiot, RA Haraszti, N Aronin, A Khvorova
Extracellular RNA: Methods and Protocols, 199-214, 2018
172018
Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system
RA Haraszti, A Coles, N Aronin, A Khvorova, MC Didiot
Bio-protocol 7 (12), e2338-e2338, 2017
102017
A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics
JF Alterman, AH Coles, LM Hall, N Aronin, A Khvorova, MC Didiot
Bio-protocol 7 (16), e2501-e2501, 2017
92017
Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains
S Ly, MC Didiot, CM Ferguson, AH Coles, R Miller, K Chase, D Echeverria, ...
Brain Communications 4 (6), fcac248, 2022
82022
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Articles 1–20