| Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and … J Gu, Y Weng, QY Zhang, H Cui, M Behr, L Wu, W Yang, L Zhang, X Ding Journal of Biological Chemistry 278 (28), 25895-25901, 2003 | 243 | 2003 |
| NADPH–cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology DS Riddick, X Ding, CR Wolf, TD Porter, AV Pandey, QY Zhang, J Gu, ... Drug Metabolism and Disposition 41 (1), 12-23, 2013 | 159 | 2013 |
| In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung … J Gu, H Cui, M Behr, L Zhang, QY Zhang, W Yang, JA Hinson, X Ding Molecular pharmacology 67 (3), 623-630, 2005 | 127 | 2005 |
| Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant X Zhang, T Su, QY Zhang, J Gu, M Caggana, H Li, X Ding Journal of Pharmacology and Experimental Therapeutics 302 (2), 416-423, 2002 | 109 | 2002 |
| Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2, 6-dichlorobenzonitrile in mouse … J Gu, QY Zhang, MB Genter, TW Lipinskas, M Negishi, DW Nebert, X Ding Journal of Pharmacology and Experimental Therapeutics 285 (3), 1287-1295, 1998 | 105 | 1998 |
| Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa X Zhang, QY Zhang, D Liu, T Su, Y Weng, G Ling, Y Chen, J Gu, ... Drug Metabolism and Disposition 33 (10), 1423-1428, 2005 | 103 | 2005 |
| Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems M Dostalek, KD Hardy, GL Milne, JD Morrow, C Chen, FJ Gonzalez, J Gu, ... Journal of biological chemistry 283 (25), 17147-17157, 2008 | 102 | 2008 |
| Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity J Gu, T Su, Y Chen, QY Zhang, X Ding Toxicology and applied pharmacology 165 (2), 158-162, 2000 | 100 | 2000 |
| Regulation of cytochrome P450 gene expression in the olfactory mucosa G Ling, J Gu, MB Genter, X Zhuo, X Ding Chemico-biological interactions 147 (3), 247-258, 2004 | 93 | 2004 |
| Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice X Zhuo, J Gu, QY Zhang, DC Spink, LS Kaminsky, X Ding Journal of Pharmacology and Experimental Therapeutics 288 (2), 463-471, 1999 | 88 | 1999 |
| Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity Y Xiao, M Ge, X Xue, C Wang, H Wang, X Wu, L Li, L Liu, X Qi, Y Zhang, ... Kidney international 73 (11), 1231-1239, 2008 | 85 | 2008 |
| Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity X Xue, L Gong, X Qi, Y Wu, G Xing, J Yao, Y Luan, Y Xiao, Y Li, X Wu, ... Toxicology letters 205 (1), 47-54, 2011 | 83 | 2011 |
| Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450 L Wu, J Gu, H Cui, QY Zhang, M Behr, C Fang, Y Weng, K Kluetzman, ... Journal of Pharmacology and Experimental Therapeutics 312 (1), 35-43, 2005 | 80 | 2005 |
| Conditional knockout of the mouse NADPH‐cytochrome p450 reductase gene L Wu, J Gu, Y Weng, K Kluetzman, P Swiatek, M Behr, QY Zhang, X Zhuo, ... Genesis 36 (4), 177-181, 2003 | 73 | 2003 |
| Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling JL Conroy, C Fang, J Gu, SO Zeitlin, W Yang, J Yang, MA VanAlstine, ... Nature neuroscience 13 (3), 284-286, 2010 | 72 | 2010 |
| Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism C Fang, M Behr, F Xie, S Lu, M Doret, H Luo, W Yang, K Aldous, X Ding, ... Toxicology and applied pharmacology 227 (1), 48-55, 2008 | 69 | 2008 |
| Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2 (−/−) mouse MB Genter, HC Liang, J Gu, X Ding, M Negishi, RA McKinnon, DW Nebert Biochemical pharmacology 55 (11), 1819-1826, 1998 | 62 | 1998 |
| Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa Y Chen, YQ Liu, T Su, X Ren, L Shi, D Liu, J Gu, QY Zhang, X Ding Biochemical pharmacology 66 (7), 1245-1251, 2003 | 55 | 2003 |
| Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa J Gu, VE Walker, TW Lipinskas, DM Walker, X Ding Toxicology and applied pharmacology 146 (1), 134-143, 1997 | 54 | 1997 |
| The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5 F Xie, X Zhou, MB Genter, M Behr, J Gu, X Ding Drug metabolism and disposition 39 (6), 947-951, 2011 | 49 | 2011 |
