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Daniel J. Karst
Daniel J. Karst
Manufacturing Scientist, Biogen
Geverifieerd e-mailadres voor biogen.com
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Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes
DJ Karst, E Serra, TK Villiger, M Soos, M Morbidelli
Biochemical Engineering Journal 110, 17-26, 2016
1422016
Process performance and product quality in an integrated continuous antibody production process
DJ Karst, F Steinebach, M Soos, M Morbidelli
Biotechnology and bioengineering 114 (2), 298-307, 2017
1372017
Design and operation of a continuous integrated monoclonal antibody production process
F Steinebach, N Ulmer, M Wolf, L Decker, V Schneider, R Wälchli, D Karst, ...
Biotechnology Progress 33 (5), 1303-1313, 2017
1042017
Continuous integrated manufacturing of therapeutic proteins
DJ Karst, F Steinebach, M Morbidelli
Current opinion in biotechnology 53, 76-84, 2018
1032018
Model based adaptive control of a continuous capture process for monoclonal antibodies production
F Steinebach, M Angarita, DJ Karst, T Müller-Späth, M Morbidelli
Journal of Chromatography A 1444, 50-56, 2016
922016
Experimental and CFD physical characterization of animal cell bioreactors: From micro-to production scale
TK Villiger, B Neunstoecklin, DJ Karst, E Lucas, M Stettler, H Broly, ...
Biochemical Engineering Journal 131, 84-94, 2018
832018
Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors
DJ Karst, E Scibona, E Serra, JM Bielser, J Souquet, M Stettler, H Broly, ...
Biotechnology and Bioengineering 114 (9), 1978-1990, 2017
742017
Development of a shake tube‐based scale‐down model for perfusion cultures
MKF Wolf, V Lorenz, DJ Karst, J Souquet, H Broly, M Morbidelli
Biotechnology and bioengineering 115 (11), 2703-2713, 2018
432018
Intracellular CHO cell metabolite profiling reveals steady‐state dependent metabolic fingerprints in perfusion culture
DJ Karst, RF Steinhoff, MRG Kopp, E Serra, M Soos, R Zenobi, ...
Biotechnology progress 33 (4), 879-890, 2017
362017
Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures
RF Steinhoff, DJ Karst, F Steinebach, MRG Kopp, GW Schmidt, A Stettler, ...
Methods 104, 33-40, 2016
202016
A two-step procedure for the design of perfusion bioreactors
MKF Wolf, A Pechlaner, V Lorenz, DJ Karst, J Souquet, H Broly, ...
Biochemical engineering journal 151, 107295, 2019
172019
Transcriptome and proteome analysis of steady‐state in a perfusion CHO cell culture process
V Bertrand, DJ Karst, A Bachmann, K Cantalupo, M Soos, M Morbidelli
Biotechnology and bioengineering 116 (8), 1959-1972, 2019
172019
Isotope labeling to determine the dynamics of metabolic response in CHO cell perfusion bioreactors using MALDI‐TOF‐MS
DJ Karst, RF Steinhoff, MRG Kopp, M Soos, R Zenobi, M Morbidelli
Biotechnology progress 33 (6), 1630-1639, 2017
102017
Monitoring of antibody glycosylation pattern based on microarray MALDI-TOF mass spectrometry
J Hajduk, M Wolf, R Steinhoff, D Karst, J Souquet, H Broly, M Morbidelli, ...
Journal of biotechnology 302, 77-84, 2019
72019
Characterization and comparison of ATF and TFF in stirred bioreactors for the continuous production of therapeutic proteins
DJ Karst, E Serra, TK Villiger, M Soos, M Morbidelli
Biochemical Engineering Journal 110, 17-26, 2016
72016
Modulation of transmembrane pressure in manufacturing scale tangential flow filtration N‐1 perfusion seed culture
DJ Karst, K Ramer, EH Hughes, C Jiang, PJ Jacobs, FG Mitchelson
Biotechnology Progress 36 (6), e3040, 2020
62020
Integrated continuous processing for the manufacture of monoclonal antibodies
D Karst, F Steinenbach, M Morbidelli
42015
Design of integrated continuous processes for high-quality biotherapeutics
F Steinebach, D Karst, M Morbidelli
Continuous Biomanufacturing-Innovative Technologies and Methods, 457-480, 2017
22017
Tuning metabolic efficiency for increased product yield in high titer fed‐batch Chinese hamster ovary cell culture
A Helfer, S Gros, D Kolwyck, DJ Karst
Biotechnology Progress 39 (3), e3327, 2023
12023
Perfusion cell culture: Challenges and potentials between lab and manufacturing scale
DJ Karst
12018
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Artikelen 1–20