Paul A. Clemons, Ph.D.
Paul A. Clemons, Ph.D.
Institute Scientist, Computational Chemical Biology, Broad Institute
Verified email at - Homepage
Cited by
Cited by
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
J Lamb, ED Crawford, D Peck, JW Modell, IC Blat, MJ Wrobel, J Lerner, ...
science 313 (5795), 1929-1935, 2006
Regulation of ferroptotic cancer cell death by GPX4
WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ...
Cell 156 (1-2), 317-331, 2014
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ...
Cell 171 (6), 1437-1452. e17, 2017
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
VS Viswanathan, MJ Ryan, HD Dhruv, S Gill, OM Eichhoff, ...
Nature 547 (7664), 453-457, 2017
Target identification and mechanism of action in chemical biology and drug discovery
M Schenone, V Dančík, BK Wagner, PA Clemons
Nature chemical biology 9 (4), 232-240, 2013
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules
A Basu, NE Bodycombe, JH Cheah, EV Price, K Liu, GI Schaefer, ...
Cell 154 (5), 1151-1161, 2013
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
MG Rees, B Seashore-Ludlow, JH Cheah, DJ Adams, EV Price, S Gill, ...
Nature chemical biology 12 (2), 109-116, 2016
Harnessing connectivity in a large-scale small-molecule sensitivity dataset
B Seashore-Ludlow, MG Rees, JH Cheah, M Cokol, EV Price, ME Coletti, ...
Cancer discovery 5 (11), 1210-1223, 2015
Data-analysis strategies for image-based cell profiling
JC Caicedo, S Cooper, F Heigwer, S Warchal, P Qiu, C Molnar, ...
Nature methods 14 (9), 849-863, 2017
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Y Zou, MJ Palte, AA Deik, H Li, JK Eaton, W Wang, YY Tseng, R Deasy, ...
Nature communications 10 (1), 1617, 2019
Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia
DB Sykes, YS Kfoury, FE Mercier, MJ Wawer, JM Law, MK Haynes, ...
Cell 167 (1), 171-186. e15, 2016
ChemBank : a small-molecule screening and cheminformatics resource database
KP Seiler, GA George, MP Happ, NE Bodycombe, HA Carrinski, S Norton, ...
Nucleic acids research 36 (suppl_1), D351-D359, 2007
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
PA Clemons, NE Bodycombe, HA Carrinski, JA Wilson, AF Shamji, ...
Proceedings of the National Academy of Sciences 107 (44), 18787-18792, 2010
Route to three-dimensional fragments using diversity-oriented synthesis
AW Hung, A Ramek, Y Wang, T Kaya, JA Wilson, PA Clemons, DW Young
Proceedings of the National Academy of Sciences 108 (17), 6799-6804, 2011
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
Y Zou, WS Henry, EL Ricq, ET Graham, VV Phadnis, P Maretich, ...
Nature 585 (7826), 603-608, 2020
Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality
L Jerby-Arnon, N Pfetzer, YY Waldman, L McGarry, D James, E Shanks, ...
Cell 158 (5), 1199-1209, 2014
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
N Kato, E Comer, T Sakata-Kato, A Sharma, M Sharma, M Maetani, ...
Nature 538 (7625), 344-349, 2016
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia
A Gutierrez, L Pan, RWJ Groen, F Baleydier, A Kentsis, J Marineau, ...
The Journal of clinical investigation 124 (2), 644-655, 2014
Multiplex cytological profiling assay to measure diverse cellular states
SM Gustafsdottir, V Ljosa, KL Sokolnicki, J Anthony Wilson, D Walpita, ...
PloS one 8 (12), e80999, 2013
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling
MJ Wawer, K Li, SM Gustafsdottir, V Ljosa, NE Bodycombe, MA Marton, ...
Proceedings of the National Academy of Sciences 111 (30), 10911-10916, 2014
The system can't perform the operation now. Try again later.
Articles 1–20