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Heleen Wortelboer
Heleen Wortelboer
TNO Systems Biology & Human Health
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The interplay of glutathione-related processes in antioxidant defense
NHP Cnubben, IMCM Rietjens, H Wortelboer, J van Zanden, ...
Environmental toxicology and pharmacology 10 (4), 141-152, 2001
5242001
The impact of food bioactives on health: in vitro and ex vivo models
K Verhoeckx, P Cotter, I López-Expósito, C Kleiveland, T Lea, A Mackie, ...
Springer Nature, 2015
3602015
Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2
JJ van Zanden, HM Wortelboer, S Bijlsma, A Punt, M Usta, ...
Biochemical pharmacology 69 (4), 699-708, 2005
2232005
Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro
CA De Kruif, JW Marsman, JC Venekamp, HE Falke, J Noordhoek, ...
Chemico-biological interactions 80 (3), 303-315, 1991
2181991
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment …
J Bentz, MP O’Connor, D Bednarczyk, JA Coleman, C Lee, J Palm, ...
Drug metabolism and disposition 41 (7), 1347-1366, 2013
1692013
The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers
HM Wortelboer, CA De Kruif, AAJ Van Iersel, HE Falke, J Noordhoek, ...
Biochemical pharmacology 40 (11), 2525-2534, 1990
1691990
Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties
MGJ Balvers, KCM Verhoeckx, P Plastina, HM Wortelboer, J Meijerink, ...
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2010
1622010
Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells
JJ van Zanden, L Geraets, HM Wortelboer, PJ van Bladeren, ...
Biochemical pharmacology 67 (8), 1607-1617, 2004
1592004
Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin
HM Wortelboer, M Usta, AE van der Velde, MG Boersma, B Spenkelink, ...
Chemical research in toxicology 16 (12), 1642-1651, 2003
1452003
Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures: the effects of model inducers on apoproteins and biotransformation activities
HM Wortelboer, CA De Kruif, AAJ Van Iersel, HE Falke, J Noordhoek, ...
Biochemical pharmacology 42 (2), 381-390, 1991
1331991
Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues
MGJ Balvers, KCM Verhoeckx, S Bijlsma, CM Rubingh, J Meijerink, ...
Metabolomics 8, 1130-1147, 2012
1252012
A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices
J Westerhout, E van de Steeg, D Grossouw, EE Zeijdner, CAM Krul, ...
European Journal of Pharmaceutical Sciences 63, 167-177, 2014
1192014
Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes
C Wegler, FZ Gaugaz, TB Andersson, JR Wiśniewski, D Busch, C Gröer, ...
Molecular pharmaceutics 14 (9), 3142-3151, 2017
1112017
The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
JJ van Zanden, H van der Woude, J Vaessen, M Usta, HM Wortelboer, ...
Biochemical pharmacology 74 (2), 345-351, 2007
982007
Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures
HM Wortelboer, ECM Van Der Linden, CA De Kruif, J Noordhoek, ...
Food and chemical toxicology 30 (7), 589-599, 1992
981992
Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes
HM Wortelboer, CA De Kruif, AAJ Van Iersel, HE Falke, J Noordhoek, ...
Biochemical pharmacology 43 (7), 1439-1447, 1992
931992
Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells
SFC Vaessen, MMH van Lipzig, RHH Pieters, CAM Krul, HM Wortelboer, ...
Drug metabolism and disposition 45 (4), 353-360, 2017
912017
Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions
A Rutten, HE Falke, JF Catsburg, HM Wortelboer, BJ Blaauboer, L Doorn, ...
Archives of toxicology 66, 237-244, 1992
861992
Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of α, β-unsaturated carbonyl compounds
HM Wortelboer, M Usta, JJ van Zanden, PJ van Bladeren, IMCM Rietjens, ...
Biochemical pharmacology 69 (12), 1879-1890, 2005
822005
Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4
AAK El-Sheikh, R Greupink, HM Wortelboer, JJMW Van Den Heuvel, ...
Translational research 162 (6), 398-409, 2013
782013
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Artikelen 1–20