| The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation MR McGill, MR Sharpe, CD Williams, M Taha, SC Curry, H Jaeschke The Journal of clinical investigation 122 (4), 1574-1583, 2012 | 838 | 2012 |
| Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis MR McGill, H Jaeschke Pharmaceutical research 30, 2174-2187, 2013 | 679 | 2013 |
| The past and present of serum aminotransferases and the future of liver injury biomarkers MR McGill EXCLI journal 15, 817, 2016 | 454 | 2016 |
| Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity MR McGill, CD Williams, Y Xie, A Ramachandran, H Jaeschke Toxicology and applied pharmacology 264 (3), 387-394, 2012 | 454 | 2012 |
| HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity MR McGill, HM Yan, A Ramachandran, GJ Murray, DE Rollins, ... Hepatology 53 (3), 974-982, 2011 | 328 | 2011 |
| Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice A Ramachandran, MR McGill, Y Xie, HM Ni, WX Ding, H Jaeschke Hepatology 58 (6), 2099-2108, 2013 | 275 | 2013 |
| Current issues with acetaminophen hepatotoxicity—a clinically relevant model to test the efficacy of natural products H Jaeschke, MR McGill, CD Williams, A Ramachandran Life sciences 88 (17-18), 737-745, 2011 | 269 | 2011 |
| Acetaminophen-induced liver injury: from animal models to humans H Jaeschke, Y Xie, MR McGill Journal of clinical and translational hepatology 2 (3), 153, 2014 | 247 | 2014 |
| Mechanisms of acetaminophen-induced cell death in primary human hepatocytes Y Xie, MR McGill, K Dorko, SC Kumer, TM Schmitt, J Forster, H Jaeschke Toxicology and applied pharmacology 279 (3), 266-274, 2014 | 241 | 2014 |
| Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications MR McGill, M Lebofsky, HRK Norris, MH Slawson, ML Bajt, Y Xie, ... Toxicology and applied pharmacology 269 (3), 240-249, 2013 | 236 | 2013 |
| Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice HM Ni, MR McGill, X Chao, K Du, JA Williams, Y Xie, H Jaeschke, ... Journal of hepatology 65 (2), 354-362, 2016 | 199 | 2016 |
| Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis J Ward, C Kanchagar, I Veksler-Lublinsky, RC Lee, MR McGill, ... Proceedings of the National Academy of Sciences 111 (33), 12169-12174, 2014 | 188 | 2014 |
| Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products H Jaeschke, CD Williams, MR McGill, Y Xie, A Ramachandran Food and Chemical Toxicology 55, 279-289, 2013 | 172 | 2013 |
| Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury HM Ni, N Boggess, MR McGill, M Lebofsky, P Borude, U Apte, H Jaeschke, ... Toxicological Sciences 127 (2), 438-450, 2012 | 169 | 2012 |
| Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans CD Williams, ML Bajt, MR Sharpe, MR McGill, A Farhood, H Jaeschke Toxicology and applied pharmacology 275 (2), 122-133, 2014 | 167 | 2014 |
| Animal models of drug-induced liver injury MR McGill, H Jaeschke Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1865 (5 …, 2019 | 147 | 2019 |
| Serum mitochondrial biomarkers and damage‐associated molecular patterns are higher in acetaminophen overdose patients with poor outcome MR McGill, VS Staggs, MR Sharpe, WM Lee, H Jaeschke, ... Hepatology 60 (4), 1336-1345, 2014 | 144 | 2014 |
| Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans MR McGill, F Li, MR Sharpe, CD Williams, SC Curry, X Ma, H Jaeschke Archives of toxicology 88, 391-401, 2014 | 137 | 2014 |
| Hepatotoxicity of a cannabidiol-rich cannabis extract in the mouse model LE Ewing, CM Skinner, CM Quick, S Kennon-McGill, MR McGill, ... Molecules 24 (9), 1694, 2019 | 127 | 2019 |
| Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients MR McGill, H Jaeschke Expert opinion on drug metabolism & toxicology 10 (7), 1005-1017, 2014 | 117 | 2014 |
Hartmut JaeschkeUniversity Distinguished Professor and Chair, University of Kansas Medical CenterVerified email at kumc.edu
