| Complement is activated by IgG hexamers assembled at the cell surface CA Diebolder, FJ Beurskens, RN De Jong, RI Koning, K Strumane, ... Science 343 (6176), 1260-1263, 2014 | 781 | 2014 |
| Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation PA van Schouwenburg, LA van de Stadt, RN de Jong, EEL van Buren, ... Annals of the rheumatic diseases 72 (1), 104-109, 2013 | 226 | 2013 |
| A novel platform for the potentiation of therapeutic antibodies based on antigen-dependent formation of IgG hexamers at the cell surface RN de Jong, FJ Beurskens, S Verploegen, K Strumane, MD van Kampen, ... PLoS biology 14 (1), e1002344, 2016 | 201 | 2016 |
| A simple, robust and highly efficient transient expression system for producing antibodies T Vink, M Oudshoorn-Dickmann, M Roza, JJ Reitsma, RN de Jong Methods 65 (1), 5-10, 2014 | 170 | 2014 |
| A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation S Koundrioukoff, ZO Jónsson, S Hasan, RN de Jong, PC van der Vliet, ... Journal of Biological Chemistry 275 (30), 22882-22887, 2000 | 168 | 2000 |
| Molecular basis of assembly and activation of complement component C1 in complex with immunoglobulin G1 and antigen G Wang, RN de Jong, ETJ van den Bremer, FJ Beurskens, AF Labrijn, ... Molecular Cell 63 (1), 135-145, 2016 | 160 | 2016 |
| Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement D Ugurlar, SC Howes, BJ de Kreuk, RI Koning, RN de Jong, FJ Beurskens, ... Science 359 (6377), 794-797, 2018 | 153 | 2018 |
| Adenovirus DNA replication: protein priming, jumping back and the role of the DNA binding protein DBP RN de Jong, PC van der Vliet, AB Brenkman Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure …, 2003 | 143 | 2003 |
| Controlled Fab-arm exchange for the generation of stable bispecific IgG1 AF Labrijn, JI Meesters, P Priem, RN De Jong, ETJ Van Den Bremer, ... Nature protocols 9 (10), 2450-2463, 2014 | 136 | 2014 |
| Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication RN De Jong, PC Van der Vliet Gene 236 (1), 1-12, 1999 | 127 | 1999 |
| Heteronuclear scalar couplings in the bases and sugar rings of nucleic acids: their determination and application in assignment and conformational analysis JH Ippel, SS Wijmenga, R De Jong, HA Heus, CW Hilbers, E De Vroom, ... Magnetic resonance in chemistry 34 (13), S156-S176, 1996 | 102 | 1996 |
| Tandem native mass-spectrometry on antibody–drug conjugates and submillion Da antibody–antigen protein assemblies on an Orbitrap EMR equipped with a high-mass quadrupole mass … A Dyachenko, G Wang, M Belov, A Makarov, RN De Jong, ... Analytical chemistry 87 (12), 6095-6102, 2015 | 98 | 2015 |
| Unraveling the macromolecular pathways of IgG oligomerization and complement activation on antigenic surfaces J Strasser, RN de Jong, FJ Beurskens, G Wang, AJR Heck, J Schuurman, ... Nano letters 19 (7), 4787-4796, 2019 | 94 | 2019 |
| Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation AR Cruz, MA Boer, J Strasser, SA Zwarthoff, FJ Beurskens, CJC de Haas, ... Proceedings of the National Academy of Sciences 118 (7), e2016772118, 2021 | 75 | 2021 |
| Functional Analysis of the Anti-adalimumab Response Using Patient-derived Monoclonal Antibodies♦ PA van Schouwenburg, S Kruithof, C Votsmeier, K van Schie, MH Hart, ... Journal of Biological Chemistry 289 (50), 34482-34488, 2014 | 63 | 2014 |
| Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation ETJ van den Bremer, FJ Beurskens, M Voorhorst, PJ Engelberts, ... MAbs 7 (4), 672-680, 2015 | 61 | 2015 |
| Symmetry and asymmetry of the RING–RING dimer of Rad18 A Huang, RG Hibbert, RN de Jong, D Das, TK Sixma, R Boelens Journal of molecular biology 410 (3), 424-435, 2011 | 55 | 2011 |
| Structure and DNA binding of the human Rtf1 Plus3 domain RN de Jong, V Truffault, T Diercks, AB Eiso, MA Daniels, R Kaptein, ... Structure 16 (1), 149-159, 2008 | 52 | 2008 |
| Enzyme free cloning for high throughput gene cloning and expression RN de Jong, MA Daniëls, R Kaptein, GE Folkers Journal of structural and functional genomics 7, 109-118, 2006 | 49 | 2006 |
| First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value L Banci, I Bertini, S Cusack, RN De Jong, U Heinemann, EY Jones, ... Acta Crystallographica Section D: Biological Crystallography 62 (10), 1208-1217, 2006 | 49 | 2006 |
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