Rob N. de Jong
Rob N. de Jong
Genmab
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Complement is activated by IgG hexamers assembled at the cell surface
CA Diebolder, FJ Beurskens, RN De Jong, RI Koning, K Strumane, ...
Science 343 (6176), 1260-1263, 2014
4812014
Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation
PA van Schouwenburg, LA van de Stadt, RN de Jong, EEL van Buren, ...
Annals of the rheumatic diseases 72 (1), 104-109, 2013
1902013
A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation
S Koundrioukoff, ZO Jónsson, S Hasan, RN de Jong, PC van der Vliet, ...
Journal of Biological Chemistry 275 (30), 22882-22887, 2000
1592000
Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication
RN De Jong, PC Van der Vliet
Gene 236 (1), 1-12, 1999
1231999
Adenovirus DNA replication: protein priming, jumping back and the role of the DNA binding protein DBP
RN de Jong, PC van der Vliet, AB Brenkman
Adenoviruses: Model and Vectors in Virus-Host Interactions, 187-211, 2003
1222003
A novel platform for the potentiation of therapeutic antibodies based on antigen-dependent formation of IgG hexamers at the cell surface
RN de Jong, FJ Beurskens, S Verploegen, K Strumane, MD van Kampen, ...
PLoS biology 14 (1), e1002344, 2016
1122016
A simple, robust and highly efficient transient expression system for producing antibodies
T Vink, M Oudshoorn-Dickmann, M Roza, JJ Reitsma, RN de Jong
Methods 65 (1), 5-10, 2014
1072014
Heteronuclear scalar couplings in the bases and sugar rings of nucleic acids: their determination and application in assignment and conformational analysis
JH Ippel, SS Wijmenga, R De Jong, HA Heus, CW Hilbers, E De Vroom, ...
Magnetic Resonance in Chemistry 34 (13), S156-S176, 1996
941996
Controlled Fab-arm exchange for the generation of stable bispecific IgG1
AF Labrijn, JI Meesters, P Priem, RN De Jong, ETJ Van Den Bremer, ...
Nature protocols 9 (10), 2450-2463, 2014
812014
Tandem native mass-spectrometry on antibody–drug conjugates and submillion Da antibody–antigen protein assemblies on an Orbitrap EMR equipped with a high-mass quadrupole mass …
A Dyachenko, G Wang, M Belov, A Makarov, RN De Jong, ...
Analytical chemistry 87 (12), 6095-6102, 2015
802015
Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement
D Ugurlar, SC Howes, BJ de Kreuk, RI Koning, RN de Jong, FJ Beurskens, ...
Science 359 (6377), 794-797, 2018
792018
Molecular basis of assembly and activation of complement component C1 in complex with immunoglobulin G1 and antigen
G Wang, RN de Jong, ETJ van den Bremer, FJ Beurskens, AF Labrijn, ...
Molecular cell 63 (1), 135-145, 2016
782016
Functional Analysis of the Anti-adalimumab Response Using Patient-derived Monoclonal Antibodies♦
PA van Schouwenburg, S Kruithof, C Votsmeier, K van Schie, MH Hart, ...
Journal of Biological Chemistry 289 (50), 34482-34488, 2014
492014
First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value
L Banci, I Bertini, S Cusack, RN De Jong, U Heinemann, EY Jones, ...
Acta Crystallographica Section D: Biological Crystallography 62 (10), 1208-1217, 2006
482006
Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
ETJ van den Bremer, FJ Beurskens, M Voorhorst, PJ Engelberts, ...
MAbs 7 (4), 672-680, 2015
472015
Enzyme free cloning for high throughput gene cloning and expression
RN de Jong, MA Daniëls, R Kaptein, GE Folkers
Journal of structural and functional genomics 7 (3-4), 109-118, 2006
472006
Structure and DNA binding of the human Rtf1 Plus3 domain
RN de Jong, V Truffault, T Diercks, AB Eiso, MA Daniels, R Kaptein, ...
Structure 16 (1), 149-159, 2008
462008
Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation
JMT Klein Gunnewiek, RI Hussein, Y Van Aarssen, D Palacios, ...
Molecular and cellular biology 20 (6), 2209-2217, 2000
442000
Symmetry and asymmetry of the RING–RING dimer of Rad18
A Huang, RG Hibbert, RN de Jong, D Das, TK Sixma, R Boelens
Journal of molecular biology 410 (3), 424-435, 2011
432011
E2–c-Cbl recognition is necessary but not sufficient for ubiquitination activity
A Huang, RN de Jong, H Wienk, GS Winkler, HTM Timmers, R Boelens
Journal of molecular biology 385 (2), 507-519, 2009
422009
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