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Anil Rana
Anil Rana
Senior Scientist at Denali
Geverifieerd e-mailadres voor dnli.com
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Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality
RI Clark, A Salazar, R Yamada, S Fitz-Gibbon, M Morselli, J Alcaraz, ...
Cell reports 12 (10), 1656-1667, 2015
4472015
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
A Rana, M Rera, DW Walker
Proceedings of the National Academy of Sciences 110 (21), 8638-8643, 2013
3362013
AMPK modulates tissue and organismal aging in a non-cell-autonomous manner
M Ulgherait, A Rana, M Rera, J Graniel, DW Walker
Cell reports 8 (6), 1767-1780, 2014
2802014
Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
A Rana, MP Oliveira, AV Khamoui, R Aparicio, M Rera, HB Rossiter, ...
Nature communications 8 (1), 448, 2017
2502017
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
BJ Andreone, L Przybyla, C Llapashtica, A Rana, SS Davis, ...
Nature Neuroscience 23 (8), 927-938, 2020
1652020
Pantethine rescues a Drosophila model for pantothenate kinase–associated neurodegeneration
A Rana, E Seinen, K Siudeja, R Muntendam, B Srinivasan, ...
Proceedings of the National Academy of Sciences 107 (15), 6988-6993, 2010
1642010
Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases
S Carra, A Boncoraglio, B Kanon, JF Brunsting, M Minoia, A Rana, ...
Journal of Biological Chemistry 285 (48), 37811-37822, 2010
1262010
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ...
Cell 184 (18), 4651-4668. e25, 2021
1232021
De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system
F Bosveld, A Rana, PE van der Wouden, W Lemstra, M Ritsema, ...
Human molecular genetics 17 (13), 2058-2069, 2008
1142008
Upregulation of the autophagy adaptor p62/SQSTM1 prolongs health and lifespan in middle-aged Drosophila
R Aparicio, A Rana, DW Walker
Cell reports 28 (4), 1029-1040. e5, 2019
1032019
Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated …
K Siudeja, B Srinivasan, L Xu, A Rana, J De Jong, EAA Nollen, ...
EMBO molecular medicine 3 (12), 755-766, 2011
982011
Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
JM Schinaman, A Rana, WW Ja, RI Clark, DW Walker
Scientific reports 9 (1), 7824, 2019
892019
Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
NN Nguyen, A Rana, C Goldman, R Moore, J Tai, Y Hong, J Shen, ...
Scientific Reports 9 (1), 3170, 2019
512019
Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication
X Yi, HI de Vries, K Siudeja, A Rana, W Lemstra, JF Brunsting, RM Kok, ...
Molecular biology of the cell 20 (3), 983-994, 2009
252009
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism
K Siudeja, NA Grzeschik, A Rana, J de Jong, OCM Sibon
Public Library of Science 7 (8), e43145, 2012
182012
Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis
F Bosveld, A Rana, W Lemstra, HH Kampinga, OCM Sibon
BMC Research Notes 1, 1-10, 2008
152008
A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of GRN knockout mice: Lipids in AD and FTD: From …
T Logan, S DeVos, MJ Simon, S Davis, J Wang, R Low, F Huang, ...
Alzheimer's & Dementia 16, e040602, 2020
42020
The role of impaired de novo Coenzyme A biosynthesis in pantothenate kinase-associated neurodegeneration
A Rana
Neurodegeneration 107 (15), 6988-93, 2010
2010
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Artikelen 1–18