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Michael Burczynski (aka Michael Ransom)
Michael Burczynski (aka Michael Ransom)
Regeneron Pharmaceuticals
Verified email at tevapharm.com - Homepage
Title
Cited by
Cited by
Year
Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the …
TM Penning, ME Burczynski, JM Jez, CF Hung, HK Lin, H Ma, M Moore, ...
Biochemical journal 351 (1), 67-77, 2000
7602000
Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones
TM Penning, ME Burczynski, CF Hung, KD McCoull, NT Palackal, ...
Chemical research in toxicology 12 (1), 1-18, 1999
5661999
The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities
S Pant, H Hilton, ME Burczynski
Biochemical pharmacology 83 (11), 1484-1494, 2012
5492012
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells
ME Burczynski, M McMillian, J Ciervo, L Li, JB Parker, RT Dunn, S Hicken, ...
Toxicological sciences 58 (2), 399-415, 2000
3382000
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
KD Davis, N Aghaeepour, AH Ahn, MS Angst, D Borsook, A Brenton, ...
Nature Reviews Neurology 16 (7), 381-400, 2020
2592020
Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells
ME Burczynski, RL Peterson, NC Twine, KA Zuberek, BJ Brodeur, ...
The journal of molecular diagnostics 8 (1), 51-61, 2006
2572006
Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression
F Allantaz, DT Cheng, T Bergauer, P Ravindran, MF Rossier, M Ebeling, ...
PloS one 7 (1), e29979, 2012
2362012
Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative …
ME Burczynski, HK Lin, TM Penning
Cancer research 59 (3), 607-614, 1999
2251999
The reactive oxygen species-and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α, β-unsaturated aldehyde 4-hydroxy-2-nonenal to 1, 4-dihydroxy-2-nonene
ME Burczynski, GR Sridhar, NT Palackal, TM Penning
Journal of Biological Chemistry 276 (4), 2890-2897, 2001
2032001
Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR‐623, a novel liver X‐receptor agonist, in healthy participants
A Katz, C Udata, E Ott, L Hickey, ME Burczynski, P Burghart, O Vesterqvist, ...
The Journal of Clinical Pharmacology 49 (6), 643-649, 2009
2012009
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor
ME Burczynski, TM Penning
Cancer research 60 (4), 908-915, 2000
1992000
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase for the treatment of Alzheimer's disease
RL Martone, H Zhou, K Atchison, T Comery, JZ Xu, X Huang, X Gong, ...
Journal of Pharmacology and Experimental Therapeutics 331 (2), 598-608, 2009
1902009
Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
ME Burczynski, AJ Dorner
Future Medicine Ltd 7 (2), 187-202, 2006
1782006
Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma
NC Twine, JA Stover, B Marshall, G Dukart, M Hidalgo, W Stadler, ...
Cancer research 63 (18), 6069-6075, 2003
1782003
Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7, 8-dihydrobenzo [a] pyrene to the activated o …
ME Burczynski, RG Harvey, TM Penning
Biochemistry 37 (19), 6781-6790, 1998
1671998
Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma
ME Burczynski, NC Twine, G Dukart, B Marshall, M Hidalgo, WM Stadler, ...
Clinical cancer research 11 (3), 1181-1189, 2005
1462005
The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation
NT Palackal, ME Burczynski, RG Harvey, TM Penning
Biochemistry 40 (36), 10901-10910, 2001
1452001
Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)
TM Penning, ME Burczynski, JM Jez, HK Lin, H Ma, M Moore, K Ratnam, ...
Molecular and cellular endocrinology 171 (1-2), 137-149, 2001
1352001
Measurement of myostatin concentrations in human serum: circulating concentrations in young and older men and effects of testosterone administration
KM Lakshman, S Bhasin, C Corcoran, LA Collins-Racie, L Tchistiakova, ...
Molecular and cellular endocrinology 302 (1), 26-32, 2009
1242009
Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis
MK McMillian, ER Grant, Z Zhong, JB Parker, L Li, RA Zivin, ...
In Vitro & Molecular Toxicology: A Journal of Basic and Applied Research 14 …, 2001
1212001
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Articles 1–20