|Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the …|
TM Penning, ME Burczynski, JM Jez, CF Hung, HK Lin, H Ma, M Moore, ...
Biochemical journal 351 (1), 67-77, 2000
|Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones|
TM Penning, ME Burczynski, CF Hung, KD McCoull, NT Palackal, ...
Chemical research in toxicology 12 (1), 1-18, 1999
|The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities|
S Pant, H Hilton, ME Burczynski
Biochemical pharmacology 83 (11), 1484-1494, 2012
|Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells|
ME Burczynski, M McMillian, J Ciervo, L Li, JB Parker, RT Dunn, S Hicken, ...
Toxicological sciences 58 (2), 399-415, 2000
|Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells|
ME Burczynski, RL Peterson, NC Twine, KA Zuberek, BJ Brodeur, ...
The journal of molecular diagnostics 8 (1), 51-61, 2006
|Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative …|
ME Burczynski, HK Lin, TM Penning
Cancer research 59 (3), 607-614, 1999
|Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression|
F Allantaz, DT Cheng, T Bergauer, P Ravindran, MF Rossier, M Ebeling, ...
PloS one 7 (1), e29979, 2012
|The reactive oxygen species-and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α, β-unsaturated aldehyde 4-hydroxy-2-nonenal to 1, 4-dihydroxy-2-nonene|
ME Burczynski, GR Sridhar, NT Palackal, TM Penning
Journal of Biological Chemistry 276 (4), 2890-2897, 2001
|Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor|
ME Burczynski, TM Penning
Cancer research 60 (4), 908-915, 2000
|Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR‐623, a novel liver X‐receptor agonist, in healthy participants|
A Katz, C Udata, E Ott, L Hickey, ME Burczynski, P Burghart, O Vesterqvist, ...
The Journal of Clinical Pharmacology 49 (6), 643-649, 2009
|Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase for the treatment of Alzheimer's disease|
RL Martone, H Zhou, K Atchison, T Comery, JZ Xu, X Huang, X Gong, ...
Journal of Pharmacology and Experimental Therapeutics 331 (2), 598-608, 2009
|Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities|
KD Davis, N Aghaeepour, AH Ahn, MS Angst, D Borsook, A Brenton, ...
Nature Reviews Neurology 16 (7), 381-400, 2020
|Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies|
ME Burczynski, AJ Dorner
Future Medicine Ltd 7 (2), 187-202, 2006
|Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma|
NC Twine, JA Stover, B Marshall, G Dukart, M Hidalgo, W Stadler, ...
Cancer research 63 (18), 6069-6075, 2003
|Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7, 8-dihydrobenzo [a] pyrene to the activated o …|
ME Burczynski, RG Harvey, TM Penning
Biochemistry 37 (19), 6781-6790, 1998
|Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma|
ME Burczynski, NC Twine, G Dukart, B Marshall, M Hidalgo, WM Stadler, ...
Clinical cancer research 11 (3), 1181-1189, 2005
|The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation|
NT Palackal, ME Burczynski, RG Harvey, TM Penning
Biochemistry 40 (36), 10901-10910, 2001
|Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)|
TM Penning, ME Burczynski, JM Jez, HK Lin, H Ma, M Moore, K Ratnam, ...
Molecular and cellular endocrinology 171 (1-2), 137-149, 2001
|Measurement of myostatin concentrations in human serum: circulating concentrations in young and older men and effects of testosterone administration|
KM Lakshman, S Bhasin, C Corcoran, LA Collins-Racie, L Tchistiakova, ...
Molecular and cellular endocrinology 302 (1), 26-32, 2009
|Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis|
MK McMillian, ER Grant, Z Zhong, JB Parker, L Li, RA Zivin, ...
In Vitro & Molecular Toxicology: A Journal of Basic and Applied Research 14 …, 2001