Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks WG Lewis, LG Green, F Grynszpan, Z Radić, PR Carlier, P Taylor, ... Angewandte Chemie 114 (6), 1095-1099, 2002 | 1071* | 2002 |
Discovery and characterization of catalysts for azide-alkyne cycloaddition by fluorescence quenching WG Lewis, FG Magallon, VV Fokin, MG Finn Journal of the American Chemical Society 126 (30), 9152-9153, 2004 | 485 | 2004 |
Accelerated bioorthogonal conjugation: a practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold SS Gupta, J Kuzelka, P Singh, WG Lewis, M Manchester, MG Finn Bioconjugate chemistry 16 (6), 1572-1579, 2005 | 404 | 2005 |
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β T Hirota, WG Lewis, AC Liu, JW Lee, PG Schultz, SA Kay Proceedings of the National Academy of Sciences 105 (52), 20746, 2008 | 300 | 2008 |
A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly SJ Stray, CR Bourne, S Punna, WG Lewis, MG Finn, A Zlotnick Proceedings of the National Academy of Sciences 102 (23), 8138-8143, 2005 | 286 | 2005 |
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase T Hirota, JW Lee, WG Lewis, EE Zhang, G Breton, X Liu, M Garcia, ... PLoS biology 8 (12), e1000559, 2010 | 242 | 2010 |
Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications WG Lewis, Z Shen, MG Finn, G Siuzdak International Journal of Mass Spectrometry 226 (1), 107-116, 2003 | 226 | 2003 |
Mammalian circadian signaling networks and therapeutic targets AC Liu, WG Lewis, SA Kay Nature chemical biology 3 (10), 630-639, 2007 | 214 | 2007 |
Host sialoglycans and bacterial sialidases: a mucosal perspective AL Lewis, WG Lewis Cellular microbiology 14 (8), 1174-1182, 2012 | 195 | 2012 |
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis WG Lewis, LS Robinson, NM Gilbert, JC Perry, AL Lewis Journal of Biological Chemistry 288 (17), 12067-12079, 2013 | 157 | 2013 |
Urinary tract infection as a preventable cause of pregnancy complications: opportunities, challenges, and a global call to action NM Gilbert, VP O'brien, S Hultgren, G Macones, WG Lewis, AL Lewis Global advances in health and medicine 2 (5), 59-69, 2013 | 150 | 2013 |
Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells Q Luo, P Kumar, TJ Vickers, A Sheikh, WG Lewis, DA Rasko, J Sistrunk, ... Infection and immunity 82 (2), 509-521, 2014 | 131 | 2014 |
Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis NM Gilbert, WG Lewis, AL Lewis PloS one 8 (3), e59539, 2013 | 119 | 2013 |
EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin P Kumar, Q Luo, TJ Vickers, A Sheikh, WG Lewis, JM Fleckenstein Infection and immunity 82 (2), 500-508, 2014 | 103 | 2014 |
Immune Activation and Suppression by Group B Streptococcus in a Murine Model of Urinary Tract Infection KA Kline, DJ Schwartz, WG Lewis, SJ Hultgren, AL Lewis Infection and immunity 79 (9), 3588, 2011 | 93 | 2011 |
Hydrolysis of the secreted sialoglycoprotein Immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis WG Lewis, LS Robinson, JC Perry, JL Bick, JF Peipert, JE Allsworth, ... Journal of Biological Chemistry, 2011 | 85 | 2011 |
The [2+ 2]‐Photocycloaddition of Aromatic Aldehydes and Ketones to 3, 4‐Dihydro‐2‐pyridones: Regioselectivity, Diastereoselectivity, and Reductive Ring Opening of the Product … T Bach, H Bergmann, H Brummerhop, W Lewis, K Harms Chemistry–A European Journal 7 (20), 4512-4521, 2001 | 81 | 2001 |
Cleavable linkers for porous silicon‐based mass spectrometry JC Meng, C Averbuj, WG Lewis, G Siuzdak, MG Finn Angewandte Chemie 116 (10), 1275-1280, 2004 | 67 | 2004 |
Gardnerella vaginalis and Prevotella bivia Trigger Distinct and Overlapping Phenotypes in a Mouse Model of Bacterial Vaginosis NM Gilbert, WG Lewis, G Li, DK Sojka, JB Lubin, AL Lewis The journal of infectious diseases 220 (7), 1099-1108, 2019 | 62 | 2019 |
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus AL Lewis, H Cao, SK Patel, S Diaz, W Ryan, AF Carlin, V Thon, WG Lewis, ... Journal of Biological Chemistry 282 (38), 27562-27571, 2007 | 54 | 2007 |