Karen van Eunen
Karen van Eunen
Section Systems Medicine of Metabolism and Signalling, Department of Pediatrics, UMCG
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The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
G Den Besten, K Van Eunen, AK Groen, K Venema, DJ Reijngoud, ...
Journal of lipid research 54 (9), 2325-2340, 2013
Short-chain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation
G Den Besten, A Bleeker, A Gerding, K van Eunen, R Havinga, ...
Diabetes 64 (7), 2398-2408, 2015
Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
G den Besten, K Lange, R Havinga, TH van Dijk, A Gerding, K van Eunen, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 305 (12 …, 2013
Measuring enzyme activities under standardized in vivo‐like conditions for systems biology
K Van Eunen, J Bouwman, P Daran‐Lapujade, J Postmus, AB Canelas, ...
The FEBS journal 277 (3), 749-760, 2010
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
P Dalle Pezze, S Ruf, AG Sonntag, M Langelaar-Makkinje, P Hall, ...
Nature communications 7 (1), 13254, 2016
Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
AB Canelas, N Harrison, A Fazio, J Zhang, JP Pitkänen, J Van Den Brink, ...
Nature communications 1 (1), 145, 2010
Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics
K van Eunen, JAL Kiewiet, HV Westerhoff, BM Bakker
PLoS computational biology 8 (4), e1002483, 2012
Protection against the metabolic syndrome by guar gum-derived short-chain fatty acids depends on peroxisome proliferator-activated receptor γ and glucagon-like peptide-1
G den Besten, A Gerding, TH van Dijk, J Ciapaite, A Bleeker, K van Eunen, ...
PLoS One 10 (8), e0136364, 2015
The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome
G den Besten, R Havinga, A Bleeker, S Rao, A Gerding, K van Eunen, ...
PloS one 9 (9), e107392, 2014
Molecular mechanisms of mTOR regulation by stress
AM Heberle, MT Prentzell, K Van Eunen, BM Bakker, SN Grellscheid, ...
Molecular & cellular oncology 2 (2), e970489, 2015
A model reduction method for biochemical reaction networks
S Rao, A der Schaft, K Eunen, BM Bakker, B Jayawardhana
BMC systems biology 8, 1-17, 2014
Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload
K van Eunen, SMJ Simons, A Gerding, A Bleeker, G den Besten, ...
PLoS computational biology 9 (8), e1003186, 2013
Gene flow between arrhenotokous and thelytokous populations of Venturia canescens (Hymenoptera)
MV Schneider, G Driessen, LW Beukeboom, R Boll, K Van Eunen, ...
Heredity 90 (3), 260-267, 2003
The importance and challenges of in vivo-like enzyme kinetics
K van Eunen, BM Bakker
Perspectives in Science 1 (1-6), 126-130, 2014
Metabolic regulation rather than de novo enzyme synthesis dominates the osmo‐adaptation of yeast
J Bouwman, J Kiewiet, A Lindenbergh, K van Eunen, M Siderius, ...
Yeast 28 (1), 43-53, 2011
Translational targeted proteomics profiling of mitochondrial energy metabolic pathways in mouse and human samples
JC Wolters, J Ciapaite, K Van Eunen, KE Niezen-Koning, A Matton, ...
Journal of proteome research 15 (9), 3204-3213, 2016
The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation
ACMF Martines, K Van Eunen, DJ Reijngoud, BM Bakker
PLoS computational biology 13 (4), e1005461, 2017
Time‐dependent regulation analysis dissects shifts between metabolic and gene‐expression regulation during nitrogen starvation in baker’s yeast
K van Eunen, J Bouwman, A Lindenbergh, HV Westerhoff, BM Bakker
The FEBS Journal 276 (19), 5521-5536, 2009
Time-dependent hierarchical regulation analysis: deciphering cellular adaptation
FJ Bruggeman, J De Haan, H Hardin, J Bouwman, S Rossell, ...
IEE Proceedings-Systems Biology 153 (5), 318-322, 2006
Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
P Riemer, M Rydenfelt, M Marks, K van Eunen, K Thedieck, BG Herrmann, ...
Journal of Cell Biology 216 (6), 1567-1577, 2017
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