Nick Plant
Nick Plant
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Cited by
Cited by
Membrane transporters in drug development
KM Giacomini, SM Huang, DJ Tweedie, LZ Benet, KLR Brouwer, X Chu, ...
Nature reviews Drug discovery 9 (3), 215, 2010
Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man
GG Gibson, NJ Plant, KE Swales, A Ayrton, W El-Sankary
Xenobiotica 32 (3), 165-206, 2002
From genes to genomes
JW Dale, MV Schantz, JD Klena
Wiley, 2002
Strategies for using in vitro screens in drug metabolism
N Plant
Drug discovery today 9 (7), 328-336, 2004
Fatty acid binding proteins: tissue-specific functions in health and disease
AE Thumser, JB Moore, NJ Plant
Current Opinion in Clinical Nutrition & Metabolic Care 17 (2), 124-129, 2014
Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays
S Forster, AE Thumser, SR Hood, N Plant
PloS one 7 (3), e33253, 2012
Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers
W El-Sankary, GG Gibson, A Ayrton, N Plant
Drug Metabolism and Disposition 29 (11), 1499-1504, 2001
Seizure control by ketogenic diet-associated medium chain fatty acids
P Chang, N Terbach, N Plant, PE Chen, MC Walker, RSB Williams
Neuropharmacology 69, 105-114, 2013
The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks
N Plant
Biochimica et Biophysica Acta (BBA)-General Subjects 1770 (3), 478-488, 2007
Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors
W El-Sankary, NJ Plant, GG Gibson, DJ Moore
Drug Metabolism and Disposition 28 (5), 493-496, 2000
Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs
DR Bell, NJ Plant, CG Rider, L Na, S Brown, I Ateitalla, SK Acharya, ...
Biochemical Journal 294 (1), 173-180, 1993
Mixed chelate copper complex, Casiopeina IIgly®, binds and degrades nucleic acids: A mechanism of cytotoxicity
A Rivero-Müller, A De Vizcaya-Ruiz, N Plant, L Ruiz, M Dobrota
Chemico-biological interactions 165 (3), 189-199, 2007
Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in …
F Al-Salman, N Plant
Toxicology and applied pharmacology 263 (1), 7-13, 2012
EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques
DJ Lamb, H Modjtahedi, NJ Plant, GAA Ferns
Atherosclerosis 176 (1), 21-26, 2004
Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element
W El-Sankary, V Bombail, GG Gibson, N Plant
Drug metabolism and disposition 30 (9), 1029-1034, 2002
Role of Sp1, C/EBPα, HNF3, and PXR in the basal-and xenobiotic-mediated regulation of the CYP3A4 gene
V Bombail, K Taylor, GG Gibson, N Plant
Drug metabolism and disposition 32 (5), 525-535, 2004
Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor α binding site within the proximal …
S Aouabdi, G Gibson, N Plant
Drug metabolism and disposition 34 (1), 138-144, 2006
Evaluation of the toxicological relevance of CYP3A4 induction.
NJ Plant, GG Gibson
Current opinion in drug discovery & development 6 (1), 50-56, 2003
Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and …
DS Pushparajah, M Umachandran, T Nazir, KE Plant, N Plant, DFV Lewis, ...
Toxicology in Vitro 22 (1), 128-145, 2008
The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes
K Howe, F Sanat, AE Thumser, T Coleman, N Plant
Xenobiotica 41 (7), 519-529, 2011
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