|Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase|
HY Cohen, C Miller, KJ Bitterman, NR Wall, B Hekking, B Kessler, ...
science 305 (5682), 390-392, 2004
|Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis|
HY Cohen, S Lavu, KJ Bitterman, B Hekking, TA Imahiyerobo, C Miller, ...
Molecular cell 13 (5), 627-638, 2004
|Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation|
NP Blackledge, AM Farcas, T Kondo, HW King, JF McGouran, ...
Cell 157 (6), 1445-1459, 2014
|Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1|
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113-117, 2018
|Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family|
A Borodovsky, H Ovaa, N Kolli, T Gan-Erdene, KD Wilkinson, HL Ploegh, ...
Chemistry & biology 9 (10), 1149-1159, 2002
|A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14|
A Borodovsky, BM Kessler, R Casagrande, HS Overkleeft, KD Wilkinson, ...
The EMBO journal 20 (18), 5187-5196, 2001
|Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19|
Y Peng, AJ Mentzer, G Liu, X Yao, Z Yin, D Dong, W Dejnirattisai, ...
Nature immunology 21 (11), 1336-1345, 2020
|Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling|
J Adam, E Hatipoglu, L O'Flaherty, N Ternette, N Sahgal, H Lockstone, ...
Cancer cell 20 (4), 524-537, 2011
|Arginine methylation regulates the p53 response|
M Jansson, ST Durant, EC Cho, S Sheahan, M Edelmann, B Kessler, ...
Nature cell biology 10 (12), 1431-1439, 2008
|A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance|
D Chauhan, Z Tian, B Nicholson, KGS Kumar, B Zhou, R Carrasco, ...
Cancer cell 22 (3), 345-358, 2012
|KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands|
AM Farcas, NP Blackledge, I Sudbery, HK Long, JF McGouran, NR Rose, ...
elife 1, e00205, 2012
|Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing|
CJ Webby, A Wolf, N Gromak, M Dreger, H Kramer, B Kessler, ML Nielsen, ...
Science 325 (5936), 90-93, 2009
|New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes|
H Sheldon, E Heikamp, H Turley, R Dragovic, P Thomas, CE Oon, R Leek, ...
Blood, The Journal of the American Society of Hematology 116 (13), 2385-2394, 2010
|Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo|
M Mortensen, DJP Ferguson, M Edelmann, B Kessler, KJ Morten, ...
Proceedings of the National Academy of Sciences 107 (2), 832-837, 2010
|Neuronal loss and brain atrophy in mice lacking cathepsins B and L|
U Felbor, B Kessler, W Mothes, HH Goebel, HL Ploegh, RT Bronson, ...
Proceedings of the National Academy of Sciences 99 (12), 7883-7888, 2002
|Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes|
M Altun, HB Kramer, LI Willems, JL McDermott, CA Leach, SJ Goldenberg, ...
Chemistry & biology 18 (11), 1401-1412, 2011
|Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib|
CR Berkers, M Verdoes, E Lichtman, E Fiebiger, BM Kessler, ...
Nature methods 2 (5), 357-362, 2005
|A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L|
J Hemelaar, VS Lelyveld, BM Kessler, HL Ploegh
Journal of biological chemistry 278 (51), 51841-51850, 2003
|Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates|
F Welker, MJ Collins, JA Thomas, M Wadsley, S Brace, E Cappellini, ...
Nature 522 (7554), 81-84, 2015
|A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae|
LM Kattenhorn, GA Korbel, BM Kessler, E Spooner, HL Ploegh
Molecular cell 19 (4), 547-557, 2005