Monitoring of the primary drying of a lyophilization process in vials AA Barresi, R Pisano, D Fissore, V Rasetto, SA Velardi, A Vallan, M Parvis, ... Chemical Engineering and Processing: Process Intensification 48 (1), 408-423, 2009 | 159 | 2009 |
Advanced approach to build the design space for the primary drying of a pharmaceutical freeze‐drying process D Fissore, R Pisano, AA Barresi Journal of pharmaceutical sciences 100 (11), 4922-4933, 2011 | 135 | 2011 |
Freeze drying of pharmaceutical excipients close to collapse temperature: Influence of the process conditions on process time and product quality AA Barresi, S Ghio, D Fissore, R Pisano Drying Technology 27 (6), 805-816, 2009 | 128* | 2009 |
Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk MB Adali, AA Barresi, G Boccardo, R Pisano Processes 8 (6), 709, 2020 | 105 | 2020 |
Heat transfer in freeze-drying apparatus R Pisano, D Fissore, AA Barresi Developments in heat transfer 10, 23799, 2011 | 103 | 2011 |
Quality by design: optimization of a freeze-drying cycle via design space in case of heterogeneous drying behavior and influence of the freezing protocol R Pisano, D Fissore, AA Barresi, P Brayard, P Chouvenc, B Woinet Pharmaceutical development and technology 18 (1), 280-295, 2013 | 99 | 2013 |
On the methods based on the Pressure Rise Test for monitoring a freeze-drying process D Fissore, R Pisano, AA Barresi Drying Technology 29 (1), 73-90, 2010 | 96 | 2010 |
Model-based monitoring and control of industrial freeze-drying processes: effect of batch nonuniformity AA Barresi, R Pisano, V Rasetto, D Fissore, DL Marchisio Drying Technology 28 (5), 577-590, 2010 | 92 | 2010 |
Surface-induced crystallization of pharmaceuticals and biopharmaceuticals: A review F Artusio, R Pisano International journal of pharmaceutics 547 (1-2), 190-208, 2018 | 90 | 2018 |
Influence of controlled ice nucleation on the freeze-drying of pharmaceutical products: the secondary drying step I Oddone, AA Barresi, R Pisano International journal of pharmaceutics 524 (1-2), 134-140, 2017 | 88 | 2017 |
Heightened cold-denaturation of proteins at the ice–water interface A Arsiccio, J McCarty, R Pisano, JE Shea Journal of the American Chemical Society 142 (12), 5722-5730, 2020 | 87 | 2020 |
Process analytical technology for monitoring pharmaceuticals freeze-drying–A comprehensive review D Fissore, R Pisano, AA Barresi Drying Technology 36 (15), 1839-1865, 2018 | 86 | 2018 |
In-line optimization and control of an industrial freeze-drying process for pharmaceuticals R Pisano, D Fissore, SA Velardi, AA Barresi Journal of Pharmaceutical Sciences 99 (11), 4691-4709, 2010 | 86 | 2010 |
The ice-water interface and protein stability: a review A Arsiccio, R Pisano Journal of Pharmaceutical Sciences 109 (7), 2116-2130, 2020 | 85 | 2020 |
Achieving continuous manufacturing in lyophilization: Technologies and approaches R Pisano, A Arsiccio, LC Capozzi, BL Trout European Journal of Pharmaceutics and Biopharmaceutics 142, 265-279, 2019 | 80 | 2019 |
From batch to continuous: freeze-drying of suspended vials for pharmaceuticals in unit-doses LC Capozzi, BL Trout, R Pisano Industrial & Engineering Chemistry Research 58 (4), 1635-1649, 2019 | 79 | 2019 |
Freeze-drying cycle optimization using model predictive control techniques R Pisano, D Fissore, AA Barresi Industrial & Engineering Chemistry Research 50 (12), 7363-7379, 2011 | 79 | 2011 |
Quality by design: scale-up of freeze-drying cycles in pharmaceutical industry R Pisano, D Fissore, AA Barresi, M Rastelli Aaps Pharmscitech 14, 1137-1149, 2013 | 77 | 2013 |
Vacuum-induced nucleation as a method for freeze-drying cycle optimization I Oddone, R Pisano, R Bullich, P Stewart Industrial & Engineering Chemistry Research 53 (47), 18236-18244, 2014 | 70 | 2014 |
In-line control of the lyophilization process. A gentle PAT approach using software sensors AA Barresi, SA Velardi, R Pisano, V Rasetto, A Vallan, M Galan International Journal of Refrigeration 32 (5), 1003-1014, 2009 | 69 | 2009 |