Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors M Schütte, T Risch, N Abdavi-Azar, K Boehnke, D Schumacher, M Keil, ... Nature communications 8 (1), 14262, 2017 | 300 | 2017 |
Assay establishment and validation of a high-throughput screening platform for three-dimensional patient-derived colon cancer organoid cultures K Boehnke, PW Iversen, D Schumacher, MJ Lallena, R Haro, J Amat, ... Journal of biomolecular screening 21 (9), 931-941, 2016 | 147 | 2016 |
Cancer stem cells in solid tumors: elusive or illusive? Y Welte, J Adjaye, HR Lehrach, CRA Regenbrecht Cell communication and signaling 8, 1-10, 2010 | 126 | 2010 |
Non-canonical hedgehog signaling is a positive regulator of the WNT pathway and is required for the survival of colon cancer stem cells JL Regan, D Schumacher, S Staudte, A Steffen, J Haybaeck, U Keilholz, ... Cell reports 21 (10), 2813-2828, 2017 | 123 | 2017 |
The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells T Redmer, Y Welte, D Behrens, I Fichtner, D Przybilla, W Wruck, ... PloS one 9 (5), e92596, 2014 | 106 | 2014 |
Stemming cancer: functional genomics of cancer stem cells in solid tumors CRA Regenbrecht, H Lehrach, J Adjaye Stem cell reviews 4, 319-328, 2008 | 74 | 2008 |
Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures D Schumacher, G Andrieux, K Boehnke, M Keil, A Silvestri, M Silvestrov, ... PLoS Genetics 15 (3), e1008076, 2019 | 70 | 2019 |
The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells T Redmer, I Walz, B Klinger, S Khouja, Y Welte, R Schäfer, ... Oncogenesis 6 (1), e291-e291, 2017 | 64 | 2017 |
The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines CRA Regenbrecht, M Jung, H Lehrach, J Adjaye BMC medical genomics 1, 1-13, 2008 | 50 | 2008 |
Characterization of small spheres derived from various solid tumor cell lines: are they suitable targets for T cells? A Busse, A Letsch, A Fusi, A Nonnenmacher, D Stather, S Ochsenreither, ... Clinical & experimental metastasis 30, 781-791, 2013 | 47 | 2013 |
Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes W Wruck, K Kashofer, S Rehman, A Daskalaki, D Berg, E Gralka, ... Scientific data 2 (1), 1-10, 2015 | 46 | 2015 |
Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model A Banning, CRA Regenbrecht, R Tikkanen Cellular signalling 26 (2), 198-207, 2014 | 45 | 2014 |
Data management strategies for multinational large-scale systems biology projects W Wruck, M Peuker, CRA Regenbrecht Briefings in bioinformatics 15 (1), 65-78, 2014 | 44 | 2014 |
Three-Dimensional Patient-Derived In Vitro Sarcoma Models: Promising Tools for Improving Clinical Tumor Management M Gaebler, A Silvestri, J Haybaeck, P Reichardt, CD Lowery, LF Stancato, ... Frontiers in Oncology 7, 203, 2017 | 41 | 2017 |
Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6 N Golob-Schwarzl, C Schweiger, C Koller, S Krassnig, M Gogg-Kamerer, ... Oncotarget 8 (60), 101224, 2017 | 39 | 2017 |
Activation of the immune response is a key feature of aging in mice TC Brink, C Regenbrecht, L Demetrius, H Lehrach, J Adjaye Biogerontology 10, 721-734, 2009 | 35 | 2009 |
Influence of eukaryotic translation initiation factor 6 on non–small cell lung cancer development and progression N Gantenbein, E Bernhart, I Anders, N Golob-Schwarzl, S Krassnig, ... European Journal of Cancer 101, 165-180, 2018 | 34 | 2018 |
Patient derived cell culture and isolation of CD133+ putative cancer stem cells from melanoma Y Welte, C Davies, R Schäfer, CRA Regenbrecht JoVE (Journal of Visualized Experiments), e50200, 2013 | 30 | 2013 |
A systems biology approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells J Jozefczuk, K Kashofer, R Ummanni, F Henjes, S Rehman, W Wruck, ... Frontiers in physiology 3, 24885, 2012 | 29 | 2012 |
Metastatic glioblastoma cells use common pathways via blood and lymphatic vessels S Frank, SA Kuhn, M Brodhun, U Mueller, B Romeike, H Kosmehl, ... Neurol Neurochir Pol 43 (2), 183-90, 2009 | 28 | 2009 |