Hein J. Wijma
TitleCited byYear
Computationally designed libraries for rapid enzyme stabilization
HJ Wijma, RJ Floor, PA Jekel, D Baker, SJ Marrink, DB Janssen
Protein Engineering, Design and Selection 27 (2), 49-58, 2014
1392014
Structure-and sequence-analysis inspired engineering of proteins for enhanced thermostability
HJ Wijma, RJ Floor, DB Janssen
Current opinion in structural biology 23 (4), 588-594, 2013
1382013
A random-sequential mechanism for nitrite binding and active site reduction in copper-containing nitrite reductase
HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters
Journal of Biological Chemistry 281 (24), 16340-16346, 2006
742006
Enantioselective enzymes by computational design and in silico screening
HJ Wijma, RJ Floor, S Bjelic, SJ Marrink, D Baker, DB Janssen
Angewandte Chemie International Edition 54 (12), 3726-3730, 2015
572015
Bidirectional catalysis by copper-containing nitrite reductase
HJ Wijma, GW Canters, S de Vries, MP Verbeet
Biochemistry 43 (32), 10467-10474, 2004
552004
Computational design gains momentum in enzyme catalysis engineering
HJ Wijma, DB Janssen
The FEBS journal 280 (13), 2948-2960, 2013
542013
Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks
JGE van Leeuwen, HJ Wijma, RJ Floor, JM van der Laan, DB Janssen
ChemBioChem 13 (1), 137-148, 2012
532012
Computational library design for increasing haloalkane dehalogenase stability
RJ Floor, HJ Wijma, DI Colpa, A Ramos‐Silva, PA Jekel, W Szymański, ...
ChemBioChem 15 (11), 1660-1672, 2014
472014
Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue
HL van Beek, HJ Wijma, L Fromont, DB Janssen, MW Fraaije
FEBS Open Bio 4, 168-174, 2014
442014
Protein film voltammetry of copper-containing nitrite reductase reveals reversible inactivation
HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters
Journal of the American Chemical Society 129 (27), 8557-8565, 2007
432007
Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion
HJ Wijma, MJ Boulanger, A Molon, M Fittipaldi, M Huber, MEP Murphy, ...
Biochemistry 42 (14), 4075-4083, 2003
422003
Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase
M Schallmey, RJ Floor, B Hauer, M Breuer, PA Jekel, HJ Wijma, ...
ChemBioChem 14 (7), 870-881, 2013
402013
Kinetic resolution of α‐Bromoamides: experimental and theoretical investigation of highly enantioselective reactions catalyzed by haloalkane dehalogenases
A Westerbeek, W Szymański, HJ Wijma, SJ Marrink, BL Feringa, ...
Advanced Synthesis & Catalysis 353 (6), 931-944, 2011
402011
Versatile peptide C-terminal functionalization via a computationally engineered peptide amidase
B Wu, HJ Wijma, L Song, HJ Rozeboom, C Poloni, Y Tian, MI Arif, ...
ACS Catalysis 6 (8), 5405-5414, 2016
352016
Computational redesign of enzymes for regio-and enantioselective hydroamination
R Li, HJ Wijma, L Song, Y Cui, M Otzen, Y Tian, J Du, T Li, D Niu, Y Chen, ...
Nature chemical biology 14 (7), 664, 2018
322018
Sensing nitrite through a pseudoazurin–nitrite reductase electron transfer relay
Y Astier, GW Canters, JJ Davis, HAO Hill, MP Verbeet, HJ Wijma
ChemPhysChem 6 (6), 1114-1120, 2005
292005
Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus
CG Crismaru, GG Wybenga, W Szymanski, HJ Wijma, B Wu, S Bartsch, ...
Appl. Environ. Microbiol. 79 (1), 185-195, 2013
282013
Computationally efficient and accurate enantioselectivity modeling by clusters of molecular dynamics simulations
HJ Wijma, SJ Marrink, DB Janssen
Journal of chemical information and modeling 54 (7), 2079-2092, 2014
272014
Real-time conformational changes and controlled orientation of native proteins inside a protein nanoreactor
V Van Meervelt, M Soskine, S Singh, GK Schuurman-Wolters, HJ Wijma, ...
Journal of the American Chemical Society 139 (51), 18640-18646, 2017
252017
Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase
B Wu, W Szymański, HJ Wijma, CG Crismaru, S de Wildeman, ...
Chemical Communications 46 (43), 8157-8159, 2010
242010
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Articles 1–20