Hein J. Wijma
Title
Cited by
Cited by
Year
Computationally designed libraries for rapid enzyme stabilization
HJ Wijma, RJ Floor, PA Jekel, D Baker, SJ Marrink, DB Janssen
Protein Engineering, Design and Selection 27 (2), 49-58, 2014
1712014
Structure-and sequence-analysis inspired engineering of proteins for enhanced thermostability
HJ Wijma, RJ Floor, DB Janssen
Current opinion in structural biology 23 (4), 588-594, 2013
1552013
Enantioselective enzymes by computational design and in silico screening
HJ Wijma, RJ Floor, S Bjelic, SJ Marrink, D Baker, DB Janssen
Angewandte Chemie International Edition 54 (12), 3726-3730, 2015
782015
A random-sequential mechanism for nitrite binding and active site reduction in copper-containing nitrite reductase
HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters
Journal of Biological Chemistry 281 (24), 16340-16346, 2006
762006
Computational redesign of enzymes for regio-and enantioselective hydroamination
R Li, HJ Wijma, L Song, Y Cui, M Otzen, J Du, T Li, D Niu, Y Chen, J Feng, ...
Nature chemical biology 14 (7), 664-670, 2018
672018
Computational design gains momentum in enzyme catalysis engineering
HJ Wijma, DB Janssen
The FEBS journal 280 (13), 2948-2960, 2013
662013
Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks
JGE van Leeuwen, HJ Wijma, RJ Floor, JM van der Laan, DB Janssen
ChemBioChem 13 (1), 137, 2012
622012
Computational library design for increasing haloalkane dehalogenase stability
RJ Floor, HJ Wijma, DI Colpa, A Ramos‐Silva, PA Jekel, W Szymański, ...
ChemBioChem 15 (11), 1660-1672, 2014
552014
Bidirectional catalysis by copper-containing nitrite reductase
HJ Wijma, GW Canters, S de Vries, MP Verbeet
Biochemistry 43 (32), 10467-10474, 2004
552004
Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue
HL van Beek, HJ Wijma, L Fromont, DB Janssen, MW Fraaije
FEBS Open Bio 4, 168-174, 2014
532014
Protein film voltammetry of copper-containing nitrite reductase reveals reversible inactivation
HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters
Journal of the American Chemical Society 129 (27), 8557-8565, 2007
462007
Real-time conformational changes and controlled orientation of native proteins inside a protein nanoreactor
V Van Meervelt, M Soskine, S Singh, GK Schuurman-Wolters, HJ Wijma, ...
Journal of the American Chemical Society 139 (51), 18640-18646, 2017
442017
Versatile peptide C-terminal functionalization via a computationally engineered peptide amidase
B Wu, HJ Wijma, L Song, HJ Rozeboom, C Poloni, Y Tian, MI Arif, ...
ACS Catalysis 6 (8), 5405-5414, 2016
442016
Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion
HJ Wijma, MJ Boulanger, A Molon, M Fittipaldi, M Huber, MEP Murphy, ...
Biochemistry 42 (14), 4075-4083, 2003
432003
Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase
M Schallmey, RJ Floor, B Hauer, M Breuer, PA Jekel, HJ Wijma, ...
ChemBioChem 14 (7), 870-881, 2013
402013
Kinetic resolution of α‐Bromoamides: experimental and theoretical investigation of highly enantioselective reactions catalyzed by haloalkane dehalogenases
A Westerbeek, W Szymański, HJ Wijma, SJ Marrink, BL Feringa, ...
Advanced Synthesis & Catalysis 353 (6), 931-944, 2011
392011
Computationally efficient and accurate enantioselectivity modeling by clusters of molecular dynamics simulations
HJ Wijma, SJ Marrink, DB Janssen
Journal of chemical information and modeling 54 (7), 2079-2092, 2014
342014
Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus
CG Crismaru, GG Wybenga, W Szymanski, HJ Wijma, B Wu, S Bartsch, ...
Applied and environmental microbiology 79 (1), 185-195, 2013
302013
Sensing nitrite through a pseudoazurin–nitrite reductase electron transfer relay
Y Astier, GW Canters, JJ Davis, HAO Hill, MP Verbeet, HJ Wijma
ChemPhysChem 6 (6), 1114-1120, 2005
302005
A robust cosolvent-compatible halohydrin dehalogenase by computational library design
H Arabnejad, M Dal Lago, PA Jekel, RJ Floor, AMWH Thunnissen, ...
Protein Engineering, Design and Selection 30 (3), 175-189, 2017
272017
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