| Genotype to phenotype: a complex problem RD Dowell, O Ryan, A Jansen, D Cheung, S Agarwala, T Danford, ... Science 328 (5977), 469-469, 2010 | 363 | 2010 |
| A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns F Notta, M Chan-Seng-Yue, M Lemire, Y Li, GW Wilson, AA Connor, ... Nature 538 (7625), 378-382, 2016 | 312 | 2016 |
| Genomic hallmarks of localized, non-indolent prostate cancer M Fraser, VY Sabelnykova, TN Yamaguchi, LE Heisler, J Livingstone, ... Nature 541 (7637), 359-364, 2017 | 306 | 2017 |
| Prediction of acute myeloid leukaemia risk in healthy individuals S Abelson, G Collord, SWK Ng, O Weissbrod, NM Cohen, E Niemeyer, ... Nature 559 (7714), 400-404, 2018 | 301 | 2018 |
| Quantitative phenotyping via deep barcode sequencing AM Smith, LE Heisler, J Mellor, F Kaper, MJ Thompson, M Chee, FP Roth, ... Genome research 19 (10), 1836-1842, 2009 | 292 | 2009 |
| Tracing the origins of relapse in acute myeloid leukaemia to stem cells LI Shlush, A Mitchell, L Heisler, S Abelson, SWK Ng, A Trotman-Grant, ... Nature 547 (7661), 104-108, 2017 | 237 | 2017 |
| A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing TS Alioto, I Buchhalter, S Derdak, B Hutter, MD Eldridge, E Hovig, ... Nature communications 6 (1), 1-13, 2015 | 227 | 2015 |
| Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples AM Smith, LE Heisler, RP St. Onge, E Farias-Hesson, IM Wallace, ... Nucleic acids research 38 (13), e142-e142, 2010 | 219 | 2010 |
| Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor LE Heisler, A Evangelou, AM Lew, J Trachtenberg, HP Elsholtz, TJ Brown Molecular and cellular endocrinology 126 (1), 59-73, 1997 | 188 | 1997 |
| Mapping the cellular response to small molecules using chemogenomic fitness signatures AY Lee, RPS Onge, MJ Proctor, IM Wallace, AH Nile, PA Spagnuolo, ... Science 344 (6180), 208-211, 2014 | 179 | 2014 |
| Distinct transcriptional profiles in ex vivo CD4+ and CD8+ T cells are established early in human immunodeficiency virus type 1 infection and are characterized by a chronic … MD Hyrcza, C Kovacs, M Loutfy, R Halpenny, L Heisler, S Yang, O Wilkins, ... Journal of virology 81 (7), 3477-3486, 2007 | 178 | 2007 |
| Genomic DNA functions as a universal external standard in quantitative real-time PCR JJ Yun, LE Heisler, IIL Hwang, O Wilkins, SK Lau, M Hyrcza, ... Nucleic acids research 34 (12), e85-e85, 2006 | 171 | 2006 |
| Genomic DNA functions as a universal external standard in quantitative real-time PCR JJ Yun, LE Heisler, IIL Hwang, O Wilkins, SK Lau, M Hyrcza, ... Nucleic acids research 34 (12), e85-e85, 2006 | 171 | 2006 |
| Widespread and functional RNA circularization in localized prostate cancer S Chen, V Huang, X Xu, J Livingstone, F Soares, J Jeon, Y Zeng, JT Hua, ... Cell 176 (4), 831-843. e22, 2019 | 131 | 2019 |
| Molecular landmarks of tumor hypoxia across cancer types V Bhandari, C Hoey, LY Liu, E Lalonde, J Ray, J Livingstone, R Lesurf, ... Nature genetics 51 (2), 308-318, 2019 | 125 | 2019 |
| CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome LE Heisler, D Torti, PC Boutros, J Watson, C Chan, N Winegarden, ... Nucleic acids research 33 (9), 2952-2961, 2005 | 120 | 2005 |
| Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories RA Taylor, M Fraser, J Livingstone, SMG Espiritu, H Thorne, V Huang, ... Nature communications 8 (1), 1-10, 2017 | 119 | 2017 |
| Childhood cerebellar tumours mirror conserved fetal transcriptional programs MC Vladoiu, I El-Hamamy, LK Donovan, H Farooq, BL Holgado, ... Nature 572 (7767), 67-73, 2019 | 109 | 2019 |
| The evolutionary landscape of localized prostate cancers drives clinical aggression SMG Espiritu, LY Liu, Y Rubanova, V Bhandari, EM Holgersen, LM Szyca, ... Cell 173 (4), 1003-1013. e15, 2018 | 108 | 2018 |
| Multiple means to the same end: the genetic basis of acquired stress resistance in yeast DB Berry, Q Guan, J Hose, S Haroon, M Gebbia, LE Heisler, C Nislow, ... PLoS Genet 7 (11), e1002353, 2011 | 103 | 2011 |
