Jonathan Whitfield
Jonathan Whitfield
Scientist, VHIO
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Cited by
Cited by
A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
J Ham, C Babij, J Whitfield, CM Pfarr, D Lallemand, M Yaniv, LL Rubin
Neuron 14 (5), 927-939, 1995
Modelling Myc inhibition as a cancer therapy
L Soucek, J Whitfield, CP Martins, AJ Finch, DJ Murphy, NM Sodir, ...
Nature 455 (7213), 679-683, 2008
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
J Whitfield, SJ Neame, L Paquet, O Bernard, J Ham
Neuron 29 (3), 629-643, 2001
Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
A Eilers, J Whitfield, C Babij, LL Rubin, J Ham
Journal of Neuroscience 18 (5), 1713-1724, 1998
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
L Soucek, JR Whitfield, NM Sodir, D Massó-Vallés, E Serrano, ...
Genes & development 27 (5), 504-513, 2013
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
WH Goodson III, L Lowe, DO Carpenter, M Gilbertson, A Manaf Ali, ...
Carcinogenesis 36 (Suppl_1), S254-S296, 2015
c-Jun and the transcriptional control of neuronal apoptosis
J Ham, A Eilers, J Whitfield, SJ Neame, B Shah
Biochemical pharmacology 60 (8), 1015-1021, 2000
Bax promotes neuronal cell death and is downregulated during the development of the nervous system
K Vekrellis, MJ McCarthy, A Watson, J Whitfield, LL Rubin, J Ham
Development 124 (6), 1239-1249, 1997
Strategies to inhibit Myc and their clinical applicability
JR Whitfield, ME Beaulieu, L Soucek
Frontiers in cell and developmental biology 5, 10, 2017
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
D Annibali, JR Whitfield, E Favuzzi, T Jauset, E Serrano, I Cuartas, ...
Nature communications 5 (1), 4632, 2014
Assembly of GABAA receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts
GH Gorrie, Y Vallis, A Stephenson, J Whitfield, B Browning, TG Smart, ...
Journal of Neuroscience 17 (17), 6587-6596, 1997
Direct inhibition of c‐Jun N‐terminal kinase in sympathetic neurones prevents c‐jun promoter activation and NGF withdrawal‐induced death
A Eilers, J Whitfield, B Shah, C Spadoni, H Desmond, J Ham
Journal of neurochemistry 76 (5), 1439-1454, 2001
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy
ME Beaulieu, T Jauset, D Massó-Vallés, S Martínez-Martín, P Rahl, ...
Science translational medicine 11 (484), eaar5012, 2019
Transforming growth factor β (TGFβ) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship …
DB Parkinson, Z Dong, H Bunting, J Whitfield, C Meier, H Marie, R Mirsky, ...
Journal of Neuroscience 21 (21), 8572-8585, 2001
The effect of environmental chemicals on the tumor microenvironment
SC Casey, M Vaccari, F Al-Mulla, R Al-Temaimi, A Amedei, ...
Carcinogenesis 36 (Suppl_1), S160-S183, 2015
Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma
D Massó-Vallés, T Jauset, E Serrano, NM Sodir, K Pedersen, NI Affara, ...
Cancer research 75 (8), 1675-1681, 2015
Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo
TB Dansen, J Whitfield, F Rostker, L Brown-Swigart, GI Evan
Journal of Biological Chemistry 281 (16), 10890-10895, 2006
Tumor microenvironment: becoming sick of Myc
JR Whitfield, L Soucek
Cellular and Molecular Life Sciences 69, 931-934, 2012
The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold
PP Graczyk, A Khan, GS Bhatia, V Palmer, D Medland, H Numata, ...
Bioorganic & medicinal chemistry letters 15 (21), 4666-4670, 2005
Tamoxifen administration to mice
J Whitfield, T Littlewood, L Soucek
Cold Spring Harbor protocols 2015 (3), pdb. prot077966, 2015
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