| High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ... Cell 163 (6), 1515-1526, 2015 | 814 | 2015 |
| High-throughput mapping of a dynamic signaling network in mammalian cells M Barrios-Rodiles, KR Brown, B Ozdamar, R Bose, Z Liu, RS Donovan, ... Science 307 (5715), 1621-1625, 2005 | 795 | 2005 |
| Online predicted human interaction database KR Brown, I Jurisica Bioinformatics 21 (9), 2076-2082, 2005 | 686 | 2005 |
| Remote ordering system for mobile commerce S Elston, B Smith, D Edelstein, C Wenkoff, K Brown, B Lonac, J Nemecek, ... US Patent App. 10/082,057, 2002 | 346 | 2002 |
| Unequal evolutionary conservation of human protein interactions in interologous networks KR Brown, I Jurisica Genome biology 8 (5), R95, 2007 | 327 | 2007 |
| Essential gene profiles in breast, pancreatic, and ovarian cancer cells R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ... Cancer discovery 2 (2), 172-189, 2012 | 286 | 2012 |
| Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance R Marcotte, A Sayad, KR Brown, F Sanchez-Garcia, J Reimand, M Haider, ... Cell 164 (1-2), 293-309, 2016 | 249 | 2016 |
| Method for establishing an electronic commerce account S Elston, B Bolleman, B Smith, K Brown, J Goldberg, D Edelstein US Patent App. 10/087,364, 2002 | 218 | 2002 |
| NAViGaTOR: network analysis, visualization and graphing Toronto KR Brown, D Otasek, M Ali, MJ McGuffin, W Xie, B Devani, IL Toch, ... Bioinformatics 25 (24), 3327-3329, 2009 | 212 | 2009 |
| Measuring error rates in genomic perturbation screens: gold standards for human functional genomics T Hart, KR Brown, F Sircoulomb, R Rottapel, J Moffat Molecular systems biology 10 (7), 733, 2014 | 209 | 2014 |
| Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6 YL Deribe, P Wild, A Chandrashaker, J Curak, MHH Schmidt, ... Science signaling 2 (102), ra84-ra84, 2009 | 182 | 2009 |
| A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers L Gortzak-Uzan, A Ignatchenko, AI Evangelou, M Agochiya, KA Brown, ... Journal of proteome research 7 (01), 339-351, 2008 | 175 | 2008 |
| Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ... Nature medicine 23 (1), 60-68, 2017 | 172 | 2017 |
| Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ... G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017 | 153 | 2017 |
| Penicillin Man K Brown The History Press, 2005 | 118 | 2005 |
| System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes W Zhang, KP Wu, MA Sartori, HB Kamadurai, A Ordureau, C Jiang, ... Molecular cell 62 (1), 121-136, 2016 | 98 | 2016 |
| Systematic identification of SH3 domain‐mediated human protein–protein interactions by peptide array target screening C Wu, MH Ma, KR Brown, M Geisler, L Li, E Tzeng, CYH Jia, I Jurisica, ... Proteomics 7 (11), 1775-1785, 2007 | 94 | 2007 |
| Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer IM Seiden-Long, KR Brown, W Shih, DA Wigle, N Radulovich, I Jurisica, ... Oncogene 25 (1), 91-102, 2006 | 89 | 2006 |
| A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities FJ Vizeacoumar, R Arnold, FS Vizeacoumar, M Chandrashekhar, ... Molecular systems biology 9 (1), 696, 2013 | 86 | 2013 |
| Analysis of hepatic glycogen‐associated proteins D Stapleton, C Nelson, K Parsawar, D McClain, R Gilbert‐Wilson, ... Proteomics 10 (12), 2320-2329, 2010 | 75 | 2010 |
Jason MoffatProfessor, University of TorontoVerified email at utoronto.ca
