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David J. Hamelin
David J. Hamelin
Verified email at umontreal.ca
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Year
Conformational sampling of membranes by Akt controls its activation and inactivation
I Lučić, MK Rathinaswamy, L Truebestein, DJ Hamelin, JE Burke, ...
Proceedings of the National Academy of Sciences 115 (17), E3940-E3949, 2018
842018
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
ML Jenkins, JP Margaria, JTB Stariha, RM Hoffmann, JA McPhail, ...
Nature Communications 9 (1), 3772, 2018
392018
Probing the architecture, dynamics, and inhibition of the PI4KIIIα/TTC7/FAM126 complex
GL Dornan, U Dalwadi, DJ Hamelin, RM Hoffmann, CK Yip, JE Burke
Journal of molecular biology 430 (18), 3129-3142, 2018
282018
The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner
DJ Hamelin, D Fournelle, JC Grenier, J Schockaert, KA Kovalchik, ...
Cell systems 13 (2), 143-157. e3, 2022
242022
Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii
CJ Powell, R Ramaswamy, A Kelsen, DJ Hamelin, DM Warshaw, J Bosch, ...
Proceedings of the National Academy of Sciences 115 (45), E10548-E10555, 2018
222018
Neolymphostin A is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic vinylogous ester
G Castro-Falcón, GS Seiler, O Demir, MK Rathinaswamy, D Hamelin, ...
Journal of medicinal chemistry 61 (23), 10463-10472, 2018
222018
Probing Protein–Membrane Interactions and Dynamics Using Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)
JTB Stariha, RM Hoffmann, DJ Hamelin, JE Burke
Protein-Ligand Interactions: Methods and Applications, 465-485, 2021
162021
The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme
P Shanbhogue, RM Hoffmann, MV Airola, R Maini, DJ Hamelin, ...
Journal of Biological Chemistry 294 (18), 7488-7502, 2019
152019
Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues
P Kubiniok, A Marcu, L Bichmann, L Kuchenbecker, H Schuster, ...
Iscience 25 (2), 103768, 2022
142022
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
SD Heitz, DJ Hamelin, RM Hoffmann, N Greenberg, G Salloum, Z Erami, ...
Journal of Biological Chemistry 294 (12), 4621-4633, 2019
132019
MhcVizPipe: A quality control software for rapid assessment of small-to large-scale immunopeptidome datasets
KA Kovalchik, Q Ma, L Wessling, F Saab, JD Duquette, P Kubiniok, ...
Molecular & Cellular Proteomics 21 (1), 2022
122022
Population genomics approaches for genetic characterization of sars-cov-2 lineages
F Mostefai, I Gamache, A N'Guessan, J Pelletier, J Huang, CL Murall, ...
Frontiers in medicine 9, 207, 2022
82022
Immunopeptidomics for Dummies: Detailed Experimental Protocols and Rapid, User-Friendly Visualization of MHC I and II Ligand Datasets with MhcVizPipe
KA Kovalchik, L Wessling, F Saab, Q Ma, J Despault, P Kubiniok, ...
bioRxiv, 2020.11. 02.360958, 2020
62020
Generation of HLA Allele-Specific Spectral Libraries to Identify and Quantify Immunopeptidomes by SWATH/DIA-MS
K Kovalchik, D Hamelin, E Caron
Clinical Proteomics: Methods and Protocols, 137-147, 2022
42022
RHybridFinder: An R package to process immunopeptidomic data for putative hybrid peptide discovery
F Saab, DJ Hamelin, Q Ma, KA Kovalchik, I Sirois, P Faridi, C Li, ...
STAR protocols 2 (4), 100875, 2021
42021
Data-driven approaches for genetic characterization of SARS-CoV-2 lineages
F Mostefai, I Gamache, J Huang, A N’Guessan, J Pelletier, ...
bioRxiv, 2021.09. 28.462270, 2021
32021
The global architecture shaping the heterogeneity and tissue‐dependency of the MHC class I immunopeptidome is evolutionarily conserved
P Kubiniok, A Marcu, L Bichmann, L Kuchenbecker, H Schuster, ...
bioRxiv, 2020
22020
Integrating Machine Learning-Enhanced Immunopeptidomics and SARS-CoV-2 Population-Scale Analyses Unveils Novel Antigenic Features for Next-Generation COVID-19 Vaccines
E Caron, K Kovalchik, D Hamelin, P Kubiniok, B Bourdin, F Mostefai, ...
2024
Characterizing the impact of the mutational landscape of SARS-CoV-2 on epitope presentation and CTL
D Hamelin
2022
Global Analysis of the Mammalian MHC class I Immunopeptidome at the Organism-Wide Scale
P Kubiniok, A Marcu, L Bichmann, L Kuchenbecker, H Schuster, ...
bioRxiv, 2020.09. 28.317750, 2020
2020
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