| The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema N Deshpande, KJ Addess, WF Bluhm, JC Merino-Ott, ... Nucleic acids research 33 (suppl_1), D233-D237, 2005 | 426 | 2005 |
| The RCSB PDB information portal for structural genomics A Kouranov, L Xie, J de la Cruz, L Chen, J Westbrook, PE Bourne, ... Nucleic acids research 34 (suppl_1), D302-D305, 2006 | 399 | 2006 |
| Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling D Petrey, Z Xiang, CL Tang, L Xie, M Gimpelev, T Mitros, CS Soto, ... Proteins: Structure, Function, and Bioinformatics 53 (S6), 430-435, 2003 | 392 | 2003 |
| DCCRN: Deep complex convolution recurrent network for phase-aware speech enhancement Y Hu, Y Liu, S Lv, M Xing, S Zhang, Y Fu, J Wu, B Zhang, L Xie arXiv preprint arXiv:2008.00264, 2020 | 371 | 2020 |
| Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis SL Kinnings, N Liu, N Buchmeier, PJ Tonge, L Xie, PE Bourne PLoS computational biology 5 (7), e1000423, 2009 | 360 | 2009 |
| Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors L Xie, J Li, L Xie, PE Bourne PLoS computational biology 5 (5), e1000387, 2009 | 307 | 2009 |
| Detecting evolutionary relationships across existing fold space, using sequence order-independent profile–profile alignments L Xie, PE Bourne Proceedings of the National Academy of sciences 105 (14), 5441-5446, 2008 | 269 | 2008 |
| Drug off-target effects predicted using structural analysis in the context of a metabolic network model RL Chang, L Xie, L Xie, PE Bourne, BØ Palsson PLoS computational biology 6 (9), e1000938, 2010 | 236 | 2010 |
| Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen MP Menden, D Wang, MJ Mason, et al. Nature Communications 10, 2674, 2019 | 222 | 2019 |
| Novel computational approaches to polypharmacology as a means to define responses to individual drugs L Xie, L Xie, SL Kinnings, PE Bourne Annual review of pharmacology and toxicology 52, 361-379, 2012 | 214 | 2012 |
| A machine learning-based method to improve docking scoring functions and its application to drug repurposing SL Kinnings, N Liu, PJ Tonge, RM Jackson, L Xie, PE Bourne Journal of chemical information and modeling 51 (2), 408-419, 2011 | 212 | 2011 |
| Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir L Xie, T Evangelidis, L Xie, PE Bourne PLoS computational biology 7 (4), e1002037, 2011 | 183 | 2011 |
| Curing methods for advanced polymer composites-a review D Abliz, Y Duan, L Steuernagel, L Xie, D Li, G Ziegmann Polymers and Polymer Composites 21 (6), 341-348, 2013 | 171 | 2013 |
| A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites L Xie, PE Bourne BMC bioinformatics 8, 1-13, 2007 | 168 | 2007 |
| Structure-based systems biology for analyzing off-target binding L Xie, L Xie, PE Bourne Current opinion in structural biology 21 (2), 189-199, 2011 | 164 | 2011 |
| The cancer microbiome: distinguishing direct and indirect effects requires a systemic view JB Xavier, VB Young, J Skufca, F Ginty, T Testerman, AT Pearson, ... Trends in cancer 6 (3), 192-204, 2020 | 146 | 2020 |
| Quantifying reproducibility in computational biology: the case of the tuberculosis drugome D Garijo, S Kinnings, L Xie, L Xie, Y Zhang, PE Bourne, Y Gil PloS one 8 (11), e80278, 2013 | 127 | 2013 |
| The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications SL Kinnings, L Xie, KH Fung, RM Jackson, L Xie, PE Bourne PLoS computational biology 6 (11), e1000976, 2010 | 116 | 2010 |
| A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery L Xie, L Xie, PE Bourne Bioinformatics 25 (12), i305-i312, 2009 | 116 | 2009 |
| Determining cysteines available for covalent inhibition across the human kinome Z Zhao, Q Liu, S Bliven, L Xie, PE Bourne Journal of medicinal chemistry 60 (7), 2879-2889, 2017 | 112 | 2017 |
Philip E. BourneUniversity of VirginiaVerified email at virginia.edu
