Ed Chouchani
Ed Chouchani
Harvard Medical School
Verified email at dfci.harvard.edu - Homepage
TitleCited byYear
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
ET Chouchani, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, ...
Nature 515 (7527), 431, 2014
8352014
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
ET Chouchani, C Methner, SM Nadtochiy, A Logan, VR Pell, S Ding, ...
Nature medicine 19 (6), 753, 2013
3612013
A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
L Kazak, ET Chouchani, MP Jedrychowski, BK Erickson, K Shinoda, ...
Cell 163 (3), 643-655, 2015
2462015
Mitochondrial redox signalling at a glance
Y Collins, ET Chouchani, AM James, KE Menger, HM Cochemé, ...
J Cell Sci 125 (4), 801-806, 2012
1902012
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury
ET Chouchani, VR Pell, AM James, LM Work, K Saeb-Parsy, C Frezza, ...
Cell metabolism 23 (2), 254-263, 2016
1872016
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
TA Prime, FH Blaikie, C Evans, SM Nadtochiy, AM James, CC Dahm, ...
Proceedings of the National Academy of Sciences 106 (26), 10764-10769, 2009
1842009
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1
ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, ...
Nature 532 (7597), 112, 2016
1552016
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113, 2018
1512018
Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function …
ET Chouchani, TR Hurd, SM Nadtochiy, PS Brookes, IM Fearnley, ...
Biochemical Journal 430 (Pt 1), 49, 2010
1052010
Proteomic approaches to the characterization of protein thiol modification
ET Chouchani, AM James, IM Fearnley, KS Lilley, MP Murphy
Current opinion in chemical biology 15 (1), 120-128, 2011
812011
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity
L Kazak, ET Chouchani, GZ Lu, MP Jedrychowski, CJ Bare, AI Mina, ...
Cell metabolism 26 (4), 660-671. e3, 2017
652017
Mitochondrial patch clamp of beige adipocytes reveals UCP1-positive and UCP1-negative cells both exhibiting futile creatine cycling
AM Bertholet, L Kazak, ET Chouchani, MG Bogaczyńska, I Paranjpe, ...
Cell metabolism 25 (4), 811-822. e4, 2017
652017
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury
VR Pell, ET Chouchani, C Frezza, MP Murphy, T Krieg
Cardiovascular research 111 (2), 134-141, 2016
472016
Accumulation of succinate controls activation of adipose tissue thermogenesis
EL Mills, KA Pierce, MP Jedrychowski, R Garrity, S Winther, S Vidoni, ...
Nature 560 (7716), 102, 2018
462018
Using exomarkers to assess mitochondrial reactive species in vivo
A Logan, HM Cochemé, PBL Pun, N Apostolova, RAJ Smith, L Larsen, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1840 (2), 923-930, 2014
422014
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction
L Kazak, ET Chouchani, IG Stavrovskaya, GZ Lu, MP Jedrychowski, ...
Proceedings of the National Academy of Sciences 114 (30), 7981-7986, 2017
392017
Moving forwards by blocking back-flow: the yin and yang of MI therapy
VR Pell, ET Chouchani, MP Murphy, PS Brookes, T Krieg
Circulation research 118 (5), 898-906, 2016
382016
Assessing the mitochondrial membrane potential in cells and in vivo using targeted click chemistry and mass spectrometry
A Logan, VR Pell, KJ Shaffer, C Evans, NJ Stanley, EL Robb, TA Prime, ...
Cell metabolism 23 (2), 379-385, 2016
382016
Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster
KE Menger, AM James, HM Cochemé, ME Harbour, ET Chouchani, ...
Cell reports 11 (12), 1856-1865, 2015
342015
Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species
TR Hurd, Y Collins, I Abakumova, ET Chouchani, B Baranowski, ...
Journal of Biological Chemistry 287 (42), 35153-35160, 2012
322012
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Articles 1–20