Ed Chouchani
Ed Chouchani
Harvard Medical School
Verified email at - Homepage
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
ET Chouchani, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, ...
Nature 515 (7527), 431-435, 2014
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113-117, 2018
A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
L Kazak, ET Chouchani, MP Jedrychowski, BK Erickson, K Shinoda, ...
Cell 163 (3), 643-655, 2015
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury
ET Chouchani, VR Pell, AM James, LM Work, K Saeb-Parsy, C Frezza, ...
Cell metabolism 23 (2), 254-263, 2016
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
ET Chouchani, C Methner, SM Nadtochiy, A Logan, VR Pell, S Ding, ...
Nature medicine 19 (6), 753-759, 2013
New advances in adaptive thermogenesis: UCP1 and beyond
ET Chouchani, L Kazak, BM Spiegelman
Cell metabolism 29 (1), 27-37, 2019
Accumulation of succinate controls activation of adipose tissue thermogenesis
EL Mills, KA Pierce, MP Jedrychowski, R Garrity, S Winther, S Vidoni, ...
Nature 560 (7716), 102-106, 2018
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1
ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, ...
Nature 532 (7597), 112-116, 2016
Coupling Krebs cycle metabolites to signalling in immunity and cancer
DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA O’Neill, ...
Nature metabolism 1 (1), 16-33, 2019
Mitochondrial redox signalling at a glance
Y Collins, ET Chouchani, AM James, KE Menger, HM Cochemé, ...
Journal of cell science 125 (4), 801-806, 2012
Metabolic adaptation and maladaptation in adipose tissue
ET Chouchani, S Kajimura
Nature metabolism 1 (2), 189-200, 2019
A quantitative tissue-specific landscape of protein redox regulation during aging
H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ...
Cell 180 (5), 968-983. e24, 2020
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity
L Kazak, ET Chouchani, GZ Lu, MP Jedrychowski, CJ Bare, AI Mina, ...
Cell metabolism 26 (4), 660-671. e3, 2017
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
TA Prime, FH Blaikie, C Evans, SM Nadtochiy, AM James, CC Dahm, ...
Proceedings of the National Academy of Sciences 106 (26), 10764-10769, 2009
Mitochondrial patch clamp of beige adipocytes reveals UCP1-positive and UCP1-negative cells both exhibiting futile creatine cycling
AM Bertholet, L Kazak, ET Chouchani, MG Bogaczyńska, I Paranjpe, ...
Cell metabolism 25 (4), 811-822. e4, 2017
H+ transport is an integral function of the mitochondrial ADP/ATP carrier
AM Bertholet, ET Chouchani, L Kazak, A Angelin, A Fedorenko, JZ Long, ...
Nature 571 (7766), 515-520, 2019
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction
L Kazak, ET Chouchani, IG Stavrovskaya, GZ Lu, MP Jedrychowski, ...
Proceedings of the National Academy of Sciences 114 (30), 7981-7986, 2017
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
PK Langston, A Nambu, J Jung, M Shibata, HI Aksoylar, J Lei, P Xu, ...
Nature immunology 20 (9), 1186-1195, 2019
pH-gated succinate secretion regulates muscle remodeling in response to exercise
A Reddy, LHM Bozi, OK Yaghi, EL Mills, H Xiao, HE Nicholson, ...
Cell 183 (1), 62-75. e17, 2020
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury
VR Pell, ET Chouchani, C Frezza, MP Murphy, T Krieg
Cardiovascular research 111 (2), 134-141, 2016
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