| SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells LMG de Kroon, R Narcisi, GGH Van Den Akker, EL Vitters, ... Scientific Reports 7 (1), 43164, 2017 | 56 | 2017 |
| Transcriptional profiling distinguishes inner and outer annulus fibrosus from nucleus pulposus in the bovine intervertebral disc GGH van den Akker, MI Koenders, FAJ van de Loo, PLEM van Lent, ... European Spine Journal 26, 2053-2062, 2017 | 53 | 2017 |
| Novel immortal human cell lines reveal subpopulations in the nucleus pulposus GGH Van den Akker, DAM Surtel, A Cremers, R Rodrigues-Pinto, ... Arthritis research & therapy 16, 1-16, 2014 | 53 | 2014 |
| The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis F Spaapen, GGH van den Akker, MMJ Caron, P Prickaerts, C Rofel, ... PloS one 8 (3), e58083, 2013 | 46 | 2013 |
| Novel immortal cell lines support cellular heterogeneity in the human annulus fibrosus GGH van den Akker, DAM Surtel, A Cremers, SM Richardson, JA Hoyland, ... PloS one 11 (1), e0144497, 2016 | 42 | 2016 |
| Increased TGF-β and BMP levels and improved chondrocyte-specific marker expression in vitro under cartilage-specific physiological osmolarity U Tan Timur, M Caron, G van den Akker, A van der Windt, J Visser, ... International journal of molecular sciences 20 (4), 795, 2019 | 25 | 2019 |
| Reporter gene comparison demonstrates interference of complex body fluids with secreted luciferase activity M Neefjes, BAC Housmans, GGH Van Den Akker, LW Van Rhijn, ... Scientific Reports 11 (1), 1359, 2021 | 22 | 2021 |
| Impaired chondrocyte U3 snoRNA expression in osteoarthritis impacts the chondrocyte protein translation apparatus EGJ Ripmeester, MMJ Caron, GGH Van Den Akker, DAM Surtel, ... Scientific Reports 10 (1), 13426, 2020 | 20 | 2020 |
| The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion MMF Steinbusch, MMJ Caron, DAM Surtel, GGH van den Akker, ... Journal of Biological Chemistry 294 (13), 5121-5136, 2019 | 20 | 2019 |
| Current practice in bicistronic IRES reporter use: a systematic review GGH van den Akker, F Zacchini, BAC Housmans, L van der Vloet, ... International Journal of Molecular Sciences 22 (10), 5193, 2021 | 17 | 2021 |
| Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology I Di Ceglie, GGH van den Akker, G Ascone, B Ten Harkel, H Häcker, ... Journal of Leucocyte Biology 101 (4), 957-966, 2017 | 17 | 2017 |
| Synovial fluid from end-stage osteoarthritis induces proliferation and fibrosis of articular chondrocytes via MAPK and RhoGTPase signaling BAC Housmans, M Neefjes, DAM Surtel, M Vitík, A Cremers, ... Osteoarthritis and Cartilage 30 (6), 862-874, 2022 | 16 | 2022 |
| Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells GG van den Akker, HM van Beuningen, EL Vitters, MI Koenders, ... Cellular signalling 40, 190-199, 2017 | 16 | 2017 |
| Ribosome dysfunction in osteoarthritis GGH van den Akker, MMJ Caron, MJ Peffers, TJM Welting Current Opinion in Rheumatology 34 (1), 61-67, 2022 | 15 | 2022 |
| A membranome-centered approach defines novel biomarkers for cellular subtypes in the intervertebral disc GGH van den Akker, LMT Eijssen, SM Richardson, LW Rhijn, JA Hoyland, ... Cartilage 11 (2), 203-220, 2020 | 15 | 2020 |
| Osteoarthritis-related inflammation blocks TGF-β’s protective effect on chondrocyte hypertrophy via (de) phosphorylation of the SMAD2/3 linker region N Thielen, M Neefjes, R Wiegertjes, G van den Akker, E Vitters, ... International Journal of Molecular Sciences 22 (15), 8124, 2021 | 14 | 2021 |
| EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell types GGH van den Akker, DAM Surtel, A Cremers, MFGA Hoes, MM Caron, ... BMC musculoskeletal disorders 17, 1-13, 2016 | 14 | 2016 |
| MK3 controls Polycomb target gene expression via negative feedback on ERK P Prickaerts, HEC Niessen, E Mouchel-Vielh, VEH Dahlmans, ... Epigenetics & Chromatin 5, 1-13, 2012 | 14 | 2012 |
| Prediction of the effect of the osteoarthritic joint microenvironment on cartilage repair M Neefjes, BAC Housmans, HM van Beuningen, EL Vitters, ... Tissue Engineering Part A 28 (1-2), 27-37, 2022 | 8 | 2022 |
| Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets LMG de Kroon, GGH van den Akker, B Brachvogel, R Narcisi, ... Bone 116, 67-77, 2018 | 8 | 2018 |
Peter van der KraanProfessor of Experimental Rheumatology, Radboud University, Medical CentreVerified email at reuma.umcn.nl
