| The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axonal degeneration K Essuman, DW Summers, Y Sasaki, X Mao, A DiAntonio, J Milbrandt Neuron 93 (6), 1334-1343. e5, 2017 | 531 | 2017 |
| TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death L Wan, K Essuman, RG Anderson, Y Sasaki, F Monteiro, EH Chung, ... Science 365 (6455), 799-803, 2019 | 383 | 2019 |
| TIR domain proteins are an ancient family of NAD+-consuming enzymes K Essuman, DW Summers, Y Sasaki, X Mao, AKY Yim, A DiAntonio, ... Current Biology 28 (3), 421-430. e4, 2018 | 215 | 2018 |
| Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver J Schug, LB McKenna, G Walton, N Hand, S Mukherjee, K Essuman, ... BMC genomics 14, 1-11, 2013 | 76 | 2013 |
| Shared TIR enzymatic functions regulate cell death and immunity across the tree of life K Essuman, J Milbrandt, JL Dangl, MT Nishimura Science 377 (6605), eabo0001, 2022 | 62 | 2022 |
| Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity EJ Brace, K Essuman, X Mao, J Palucki, Y Sasaki, J Milbrandt, ... PLoS genetics 18 (6), e1010246, 2022 | 8 | 2022 |
| The enzymatic function of the TIR domain: from axon degeneration to innate immunity KA Essuman Washington University in St. Louis, 2020 | 1 | 2020 |
| Inhibitors of SARM1 NADase activity and uses thereof J Milbrandt, K Essuman, Y Sasaki, A DiAntonio, MAO Xianrong, R Devraj, ... US Patent 11,903,935, 2024 | | 2024 |
| The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations E Klontz, JO Obi, Y Wang, G Glendening, J Carr, C Tsibouris, S Buddula, ... Journal of Biological Chemistry 299 (11), 2023 | | 2023 |
| IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY JD Milbrandt, A DiAntonio, K Essuman, MAO Xianrong, Y Sasaki, ... US Patent App. 18/059,838, 2023 | | 2023 |
| Inhibitors of SARM1 NADase activity and uses thereof J Milbrandt, K Essuman, Y Sasaki, A DiAntonio, MAO Xianrong, R Devraj, ... US Patent 11,253,503, 2022 | | 2022 |
| IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY JD Milbrandt, A DiAntonio, K Essuman, MAO Xianrong, Y Sasaki, ... US Patent App. 16/651,196, 2020 | | 2020 |
| Redefining the TIR domain: From Axon Degeneration to Innate Immunity and Beyond K Essuman, L Wan, DW Summers, RG Anderson, Y Sasaki, X Mao, ... The Journal of Immunology 202 (1_Supplement), 64.1-64.1, 2019 | | 2019 |
