Laszlo Orfi
Laszlo Orfi
Department of Pharmaceutical Chemistry, Semmelweis University, Vichem Ltd.
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Cited by
Cited by
Flk-1 as a target for tumor growth inhibition
LM Strawn, G McMahon, H App, R Schreck, WR Kuchler, MP Longhi, ...
Cancer Research 56 (15), 3540-3545, 1996
High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter
C Özvegy-Laczka, T Hegedűs, G Várady, O Ujhelly, JD Schuetz, A Varadi, ...
Molecular pharmacology 65 (6), 1485-1495, 2004
AXL is a potential target for therapeutic intervention in breast cancer progression
YX Zhang, PG Knyazev, YV Cheburkin, K Sharma, YP Knyazev, L Orfi, ...
Cancer research 68 (6), 1905-1915, 2008
Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti‐cancer effects and pharmacological properties
C Hegedűs, C Özvegy‐Laczka, A Apati, M Magocsi, K Nemet, L Őrfi, ...
British journal of pharmacology 158 (4), 1153-1164, 2009
Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1
T Hegedűs, L Őrfi, A Seprődi, A Váradi, B Sarkadi, G Kéri
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002
Treatment of platelet derived growth factor related disorders such as cancers
KP Hirth, E Mann, LK Shawyer, A Ullrich, I Szekely, T Bajor, J Haimichael, ...
US Patent 6,331,555, 2001
Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
S Blencke, B Zech, O Engkvist, Z Greff, L Őrfi, Z Horváth, G Kéri, A Ullrich, ...
Chemistry & biology 11 (5), 691-701, 2004
Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes
A Herrero, A Pinto, P Colón-Bolea, B Casar, M Jones, L Agudo-Ibáńez, ...
Cancer cell 28 (2), 170-182, 2015
Acid− base profiling of imatinib (gleevec) and its fragments
Z Szakács, S Béni, Z Varga, L Örfi, G Kéri, B Noszál
Journal of medicinal chemistry 48 (1), 249-255, 2005
Reliability of logP predictions based on calculated molecular descriptors: a critical review
D Eros, I Kovesdi, L Orfi, K Takacs-Novak, G Acsády, G Kéri
Current medicinal chemistry 9 (20), 1819-1829, 2002
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling
SA Barman, F Chen, Y Su, C Dimitropoulou, Y Wang, JD Catravas, W Han, ...
Arteriosclerosis, thrombosis, and vascular biology 34 (8), 1704-1715, 2014
Leads for antitubercular compounds from kinase inhibitor library screens
S Magnet, RC Hartkoorn, R Székely, J Pató, JA Triccas, P Schneider, ...
Tuberculosis 90 (6), 354-360, 2010
Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling
K Godl, OJ Gruss, J Eickhoff, J Wissing, S Blencke, M Weber, H Degen, ...
Cancer Research 65 (15), 6919-6926, 2005
Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion
J Rybniker, JM Chen, C Sala, RC Hartkoorn, A Vocat, A Benjak, ...
Cell Host & Microbe 16 (4), 538-548, 2014
A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling
R Székely, F Wáczek, I Szabadkai, G Németh, B Hegymegi-Barakonyi, ...
Immunology letters 116 (2), 225-231, 2008
Application of neural networks in structure–activity relationships
I Kövesdi, MF Dominguez‐Rodriguez, L Ôrfi, G Náray‐Szabó, A Varró, ...
Medicinal research reviews 19 (3), 249-269, 1999
Treatment of platelet derived growth factor related disorders such as cancers
KP Hirth, DP Schwartz, E Mann, LK Shawver, G Keri, I Szekely, T Bajor, ...
US Patent 5,700,823, 1997
Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer …
C Hegedüs, K Truta-Feles, G Antalffy, G Várady, K Nemet, ...
Biochemical pharmacology 84 (3), 260-267, 2012
Small-molecule inhibitors of NADPH oxidase 4
G Borbély, I Szabadkai, Z Horváth, P Markó, Z Varga, N Breza, F Baska, ...
Journal of medicinal chemistry 53 (18), 6758-6762, 2010
Quantitative analysis of peptides with NMR spectroscopy
CK Larive, D Jayawickrama, L Orfi
Applied Spectroscopy 51 (10), 1531-1536, 1997
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