|Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction|
MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, ...
Molecular cell 6 (1), 87-97, 2000
|Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes|
RN Kulkarni, JC Brüning, JN Winnay, C Postic, MA Magnuson, CR Kahn
Cell 96 (3), 329-339, 1999
|Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase|
C Postic, M Shiota, KD Niswender, TL Jetton, Y Chen, JM Moates, ...
Journal of Biological Chemistry 274 (1), 305-315, 1999
|Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice|
C Postic, J Girard
The Journal of clinical investigation 118 (3), 829-838, 2008
|Role of the liver in the control of carbohydrate and lipid homeostasis|
C Postic, R Dentin, J Girard
Diabetes & metabolism 30 (5), 398-408, 2004
|Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression|
R Dentin, JP Pégorier, F Benhamed, F Foufelle, P Ferré, V Fauveau, ...
Journal of Biological Chemistry 279 (19), 20314-20326, 2004
|Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice|
R Dentin, F Benhamed, I Hainault, V Fauveau, F Foufelle, JRB Dyck, ...
Diabetes 55 (8), 2159-2170, 2006
|DNA excision in liver by an albumin‐Cre transgene occurs progressively with age|
C Postic, MA Magnuson
genesis 26 (2), 149-150, 2000
|Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid …|
R Dentin, J Girard, C Postic
Biochimie 87 (1), 81-86, 2005
|Brain glucagon-like peptide–1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage|
C Knauf, PD Cani, C Perrin, MA Iglesias, JF Maury, E Bernard, ...
The Journal of clinical investigation 115 (12), 3554-3563, 2005
|Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation|
R Dentin, F Benhamed, JP Pégorier, F Foufelle, B Viollet, S Vaulont, ...
The Journal of clinical investigation 115 (10), 2843-2854, 2005
|Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD|
A Montagner, A Polizzi, E Fouché, S Ducheix, Y Lippi, F Lasserre, ...
Gut 65 (7), 1202-1214, 2016
|The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans|
F Benhamed, PD Denechaud, M Lemoine, C Robichon, M Moldes, ...
The Journal of clinical investigation 122 (6), 2176-2194, 2012
|The role of the lipogenic pathway in the development of hepatic steatosis|
C Postic, J Girard
Diabetes & metabolism 34 (6), 643-648, 2008
|Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice|
J Bricambert, J Miranda, F Benhamed, J Girard, C Postic, R Dentin
The Journal of clinical investigation 120 (12), 4316-4331, 2010
|ChREBP, a transcriptional regulator of glucose and lipid metabolism|
C Postic, R Dentin, PD Denechaud, J Girard
Annu. Rev. Nutr. 27, 179-192, 2007
|Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women|
L Hoyles, JM Fernandez-Real, M Federici, M Serino, J Abbott, ...
Nature medicine 24 (7), 1070-1080, 2018
|Hepatocyte-specific mutation establishes retinoid X receptor α as a heterodimeric integrator of multiple physiological processes in the liver|
YJY Wan, D An, Y Cai, JJ Repa, T Hung-Po Chen, M Flores, C Postic, ...
Molecular and cellular biology 20 (12), 4436-4444, 2000
|Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism|
P She, M Shiota, KD Shelton, R Chalkley, C Postic, MA Magnuson
Molecular and cellular biology 20 (17), 6508-6517, 2000
|ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver|
PD Denechaud, P Bossard, JMA Lobaccaro, L Millatt, B Staels, J Girard, ...
The Journal of clinical investigation 118 (3), 956-964, 2008