Joseph R Luft
Joseph R Luft
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A deliberate approach to screening for initial crystallization conditions of biological macromolecules
JR Luft, RJ Collins, NA Fehrman, AM Lauricella, CK Veatch, GT DeTitta
Journal of structural biology 142 (1), 170-179, 2003
Structure of the insecticidal bacterial δ-endotoxin Cry3Bb1 of Bacillus thuringiensis
N Galitsky, V Cody, A Wojtczak, D Ghosh, JR Luft, W Pangborn, L English
Acta Crystallographica Section D: Biological Crystallography 57 (8), 1101-1109, 2001
Device for growing crystals
GT Detitta, JR Luft
US Patent 5,400,741, 1995
Structures of human transthyretin complexed with thyroxine at 2.0 Å resolution and 3', 5'-dinitro-N-acetyl-L-thyronine at 2.2 Å resolution
A Wojtczak, V Cody, JR Luft, W Pangborn
Acta Crystallographica Section D: Biological Crystallography 52 (4), 758-765, 1996
Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data
WN Price Ii, Y Chen, SK Handelman, H Neely, P Manor, R Karlin, R Nair, ...
Nature biotechnology 27 (1), 51-57, 2009
A method to produce microseed stock for use in the crystallization of biological macromolecules
JR Luft, GT DeTitta
Acta Crystallographica Section D: Biological Crystallography 55 (5), 988-993, 1999
Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22: kinetics, crystallography, and potential as selectable markers
WS Lewis, V Cody, N Galitsky, JR Luft, W Pangborn, SK Chunduru, ...
Journal of Biological Chemistry 270 (10), 5057-5064, 1995
Macromolecular crystallization in a high throughput laboratory—the search phase
JR Luft, J Wolfley, I Jurisica, J Glasgow, S Fortier, GT DeTitta
Journal of Crystal Growth 232 (1-4), 591-595, 2001
Mechanism of molecular recognition. Structural aspects of 3, 3'-diiodo-L-thyronine binding to human serum transthyretin.
A Wojtczak, J Luft, V Cody
Journal of Biological Chemistry 267 (1), 353-357, 1992
Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal …
V Cody, JR Luft, W Pangborn
Acta Crystallographica D Biological Crystallography 61 (2), 147-55, 2005
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
TL Arakaki, FS Buckner, JR Gillespie, NA Malmquist, MA Phillips, ...
Molecular microbiology 68 (1), 37-50, 2008
Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis carinii Dihydrofolate Reductase Complexes with Folate and NADP+,
V Cody, N Galitsky, D Rak, JR Luft, W Pangborn, SF Queener
Biochemistry 38 (14), 4303-4312, 1999
Method for screening microcrystallizations for crystal formation
BD Santarsiero, RC Stevens, PG Schultz, JM Jaklevic, DT Yegian, ...
US Patent 6,630,006, 2003
Automatic classification of sub-microlitre protein-crystallization trials in 1536-well plates
CA Cumbaa, A Lauricella, N Fehrman, C Veatch, R Collins, JR Luft, ...
Acta Crystallographica Section D: Biological Crystallography 59 (9), 1619-1627, 2003
Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor …
PW Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R ...
Journal of Medicinal Chemistry 41 (18), 3426-34, 1998
Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 Å resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two …
A Wojtczak, V Cody, JR Luft, W Pangborn
Acta Crystallographica Section D: Biological Crystallography 57 (8), 1061-1070, 2001
Intelligent decision support for protein crystal growth
I Jurisica, P Rogers, JI Glasgow, S Fortier, JR Luft, JR Wolfley, MA Bianca, ...
IBM Systems Journal 40 (2), 394-409, 2001
[7] Kinetic aspects of macromolecular crystallization
JR Luft, GT Detitta
Methods in enzymology 276, 110-131, 1997
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase
J Bosch, MA Robien, C Mehlin, E Boni, A Riechers, FS Buckner, ...
Journal of medicinal chemistry 49 (20), 5939-5946, 2006
Crystallization screening: the influence of history on current practice
JR Luft, J Newman, EH Snell
Acta Crystallographica Section F 70 (7), 835-853, 2014
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